Anti-cholinergic Na+ channel blockade K+ channel blockade Alpha 1 antagonism Serotonin reuptake inhibition GABA antagonism. Anticholinergic toxidrome Wide QRS Prolonged QT Hypotension Seritonin syndrome Seizures. TCA mechanisms of Toxicity. Anticholinergic Toxidrome.
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Na+ channel blockade
K+ channel blockade
Alpha 1 antagonism
Serotonin reuptake inhibition
Dopamine is a precursor to norepinephrine
Dopamine stimulates the release of stored norepinephrine
Dopamine stimulates adrenergic receptors
Wide QRS (Na+ channel blockade)
Cocaine and other sympathomimetics
Haldol and other neuroleptics
Could Fab fragments be the cure for the TCA overdose??
Urine TCA screen
Dip stick screen, immunoassay
HORRIBLE specificity thus the lab doesn’t even do it
Serum TCA levels
Do NOT correlate with toxicity