Parkinson’s Disease: A World of Promise. Sarah Click Dr. Julie Gurwell Spring 2006. Background . Movement disorder Affects over 1 million people usually middle aged 2 nd most common ND disorder behind AD. Background cont’d. Progression due to loss of DA neurons in the brain
Dr. Julie Gurwell
Standard criteria to diagnose is 2 of these
Decrease in balance performance and gait
Hypophonia (motor)Background cont’d
Drapier et al. studied 27 patients that underwent bilateral STN DBS between 1999 and 2002
19 men and 8 women took part in the study
Goal was to determine quality of life before and after surgery
Age ≤ 75
Drug induced dyskinesias
Marked cerebral atrophy on MRI
Major depression before surgerySTN DBS
Krause et al studied 27 patients that underwent bilateral STN DBS in 1997
Age range from 44-72
Symptom duration 7-25 yrs
Mean follow-up time ~29.8 months (range 23-55)
Goal similar to previous study
Patients with advanced PD
Severe pharmacological side effects
None listedSTN DBS cont’d
Note: most adverse events were related to amplitude and could be fixed if the IPG was turned down
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