Factors influencing release
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Factors influencing release. size of drug particles. Factors influencing release. rate and extent of disintegration choice and conc’n of disintegrant. Factors influencing release. choice and conc’n of lubricant. compression pressure. Processing Problems. capping, lamination, chipping.

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Factors influencing release

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Factors influencing release

Factors influencing release

  • size of drug particles


Factors influencing release1

Factors influencing release

  • rate and extent of disintegration

    • choice and conc’n of disintegrant


Factors influencing release2

Factors influencing release

choice and conc’n of lubricant

compression pressure


Processing problems

Processing Problems

  • capping, lamination, chipping


Processing problems1

Processing problems

  • sticking

  • mottling

  • weight and hardness variation


Tablet evaluation

Tablet Evaluation

  • these tests are mandatory in the US and the procedures are outlined in the USP

    • dose uniformity

      • by weight variation

      • by content

    • disintegration


Dissolution testing

Dissolution testing


Unofficial tests

Unofficial tests

mechanical strength

  • attrition resistance (friability)

  • fracture resistance

  • porosity


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