Factors influencing release
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Factors influencing release. size of drug particles. Factors influencing release. rate and extent of disintegration choice and conc’n of disintegrant. Factors influencing release. choice and conc’n of lubricant. compression pressure. Processing Problems. capping, lamination, chipping.

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Factors influencing release
Factors influencing release

  • size of drug particles


Factors influencing release1
Factors influencing release

  • rate and extent of disintegration

    • choice and conc’n of disintegrant


Factors influencing release2
Factors influencing release

choice and conc’n of lubricant

compression pressure


Processing problems
Processing Problems

  • capping, lamination, chipping


Processing problems1
Processing problems

  • sticking

  • mottling

  • weight and hardness variation


Tablet evaluation
Tablet Evaluation

  • these tests are mandatory in the US and the procedures are outlined in the USP

    • dose uniformity

      • by weight variation

      • by content

    • disintegration



Unofficial tests
Unofficial tests

mechanical strength

  • attrition resistance (friability)

  • fracture resistance

  • porosity


  • ad