Fig. 1.11. Nucleus: structure and function. Heterochromatin = too compacted, transcriptionally inactive. nuclear envelope. Nucleolus. Nucleoplasm. Euchromatin = can be transcriptionally active. Nuclear envelope and lamina. cytoplasm. N. lamina. Nuclear pore. heterochromatin.
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too compacted, transcriptionally inactive
Euchromatin = can be transcriptionally active
Lamin phosphorylation in prophase disassembles the nuclear lamina & allows for nuc. envel. breakdown
Laminins are extracellular proteins, unrelated
hi [H family+]
pyruvateInner Membrane and matrix
Synthesis of secreted and membrane proteinsRough endoplasmic reticulum
SRP = signal recognition particle
CIS & translocon
RER retrieval, PO4 on mannose,
fucose and glucose addition
sialic acid addition, sortingProtein modifications occur in steps in the Golgi. The extent of changes varies.
Karp, Fig. 8.20
trans Golgi network
Cut open liposome
Oligosaccharides - always face out
Covalently linked to a glycophospholipid.
E.G.: Normal cellular scrapie protein
& alkaline phosphatase
Covalently linked to fatty acid
Or, PMPs could bind to specific lipid heads.
Specific interaction between IMP & PMP
Diffusion thru’ passive transporters
No effect on inward transport
No effect on outward transport
Favors inward transport
Opposes outward transport
Opposes inward transport
Favors outward transport