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Forum for Deans, Heads and Chairs Mitra Dutta, PhD Vice Chancellor for Research UIC Distinguished Professor. OVERVIEW of the OFFICE OF THE VICE CHANCELLOR FOR RESEARCH. Research Development Services (RDS) AND Office of Research Services (ORS). To be presented during the 3:00pm session.

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Forum for deans heads and chairs mitra dutta phd vice chancellor for research

  • Forum for Deans, Heads and Chairs

  • Mitra Dutta, PhD

  • Vice Chancellor for Research

  • UIC Distinguished Professor


Forum for deans heads and chairs mitra dutta phd vice chancellor for research

OVERVIEW of the

OFFICE OF THE VICE CHANCELLOR FOR RESEARCH


Forum for deans heads and chairs mitra dutta phd vice chancellor for research

Research DevelopmentServices (RDS)

AND

Office of Research Services (ORS)

To be presented during the 3:00pm session.


Total dollars awarded fy 2008 fy 2012

Total DollarsAwarded – FY 2008- FY 2012

Millions

*2010 includes ARRA awards


Office for the protection of research subjects oprs

Office for the Protection of Research Subjects (OPRS)


Goals of the uic human subjects protection program

Goals of the UIC Human Subjects Protection Program

To ensure a comprehensive Human Subjects Protections Program (HSPP):

  • Utilizing the highest ethical and professional standards

  • Affording the highest possible protections for our human subjects

    • Minimize risk to subjects; and

    • Maximize benefits of the research


Human subjects

Human Subjects

  • living individual(s) about whom an investigator (whether professional or student) conducting research obtains:

  • (1) data through intervention or interaction with the individual, or

  • (2) identifiable private information.

  • 45CFR46.102(f)


Getting started includes information about

Getting Started – Includes information about:

“Human Subjects Research”

“Key Research Personnel”

Investigator Training requirements

The role of the UIC IRB

The types of protocol review, including:

  • Determinations

  • Exemptions

  • Expedited IRB Review

  • Convened (full) IRB review

  • Others: Amendments, CR, Prompt Reports

    Decision Trees (e.g. medical record review research)

    Research at the Jesse Brown VAMC

    Tips for obtaining informed consent

    Helpful links


Forum for deans heads and chairs mitra dutta phd vice chancellor for research

Contact Us

  • West Side Office: Room 203B, AOB,

  • 1737 West Polk Street

  • Phone 312-996-1711

  • Email: [email protected]

  • East Side Satellite Office (M,W 2 – 4 pm)

  • Room 3108A, BSB

  • Phone 312-996-7742

  • URL: www.research.uic.edu/protocolreview/irb


Office of animal care and institutional biosafety oacib

Office ofAnimal Care and Institutional Biosafety (OACIB)


Forum for deans heads and chairs mitra dutta phd vice chancellor for research

Animal Care Committee (ACC)

Office for Animal Care and Institutional Biosafety

OACIB provides administrative support for the review and approval of research protocols (experiments) involving animals, recombinant DNA and infectious agents, and ensures compliance with regulations related to the use of controlled substances in animal and laboratory research. The goal of the office is to facilitate the protocol writing/review process and navigation of the regulatory issues to ensure compliance with the regulations for the protection and welfare of animals, protection and safety of investigators, and the University.

Animal Care Committee (ACC)

Oversight for all use of all live vertebrate animals in

  • Research

  • Testing

  • Teaching

OLAW/NIH

USDA

AAALAC

SPONSOR

GUIDE

ILAR

DEA

IDPR


Forum for deans heads and chairs mitra dutta phd vice chancellor for research

Institutional Biosafety Committee (IBC)

Office for Animal Care and Institutional Biosafety

OACIB provides administrative support for the review and approval of research protocols (experiments) involving animals, recombinant DNA and infectious agents, and ensures compliance with regulations related to the use of controlled substances in animal and laboratory research. The goal of the office is to facilitate the protocol writing/review process and navigation of the regulatory issues to ensure compliance with the regulations for the protection and welfare of animals, protection and safety of investigators, and the University.

Institutional Biosafety Committee (IBC)

Oversight of all research involving

rDNA

Infectious agents/toxins

Select Agents (EHSO)

OBA

CDC

USDA


Web sites

Web Sites

Office of Animal Care and Institutional Biosafety

ACC:www.research.uic.edu/protocolreview/acc/index.shtml

IBC:www.research.uic.edu/protocolreview/ibc/index.shtml

Controlled Substances:www.research.uic.edu/protocolreview/cs/index.shtml

Meeting DatesForms

Education/TrainingPolicies/Guidance

FAQsOnline Resources

Contact Information


Forum for deans heads and chairs mitra dutta phd vice chancellor for research

Office of Animal Care and Institutional Biosafety

Regulations Pertaining to Research

Animals

rDNA

Infectious Agents

Toxins- Biological

Controlled Substances

Select Agents

Humans

Chemicals

Radionucleotides

X-rays/Irradiators

Lasers

Embryonic Stem Cells

Conflict of Time/Commitment

Conflict of Interest

Import/Export

Material Transfer


Forum for deans heads and chairs mitra dutta phd vice chancellor for research

Contact Us

  • West Side Office: Room 203B, AOB,

  • 1737 West Polk Street

  • Phone 312-996-1711

  • Email: [email protected]

  • East Side Satellite Office (M,W 2 – 4 pm)

  • Room 3108A, BSB

  • Phone 312-996-7742

  • URL: www.research.uic.edu/protocolreview/irb


Conflict of interest coi

Conflictof Interest (COI)


Forum for deans heads and chairs mitra dutta phd vice chancellor for research

The Changing Environment

  • Federal regulations

  • University Policy

Main Points

  • COI Defined

  • COI and RNUA

  • Reporting and Managing Conflicts

  • COI Resources

Conflict of Interest


Forum for deans heads and chairs mitra dutta phd vice chancellor for research

Conflict of Interest

What is financial conflict of interest?

  • “A ‘conflict of interest’ arises when an academic staff member is in a position to influence either directly or indirectly University business, research, or other decisions in ways that could lead to gain for the academic staff member, the staff member's family, or others to the detriment of the University's integrity and its missions of teaching, research, and public service.”

    • “Family" is defined as one's spouse or domestic partner,

    • parents, siblings and children.

    • Conflicts reside in a situation, and do not imply

      improper behavior.


Forum for deans heads and chairs mitra dutta phd vice chancellor for research

Conflict of Interest

Report of Non-University Activities (RNUA)

  • Annual Reporting of Non University Activities is the implementation of conflict of interest policies and regulations for both conflict of interest and conflict of commitment.

    • All academic staff complete the form, even if there are no outside activities to disclose.

    • 24/7 during the contract period.

      Resolution always begins with RNUA disclosure and sometimes involves a combination of conflict management techniques.


Forum for deans heads and chairs mitra dutta phd vice chancellor for research

Conflict of Interest

PHS FCOI Regulations (2011)

  • These regulations require HHS, PHS, and NIH Investigators and senior/key research personnel to:

  • Disclose significant financial interests (SFIs) at the time of proposal submission

  • Disclose sponsored or reimbursed travel at the time of proposal submission

  • Update disclosures within 30 days of any newly acquired or discovered SFIs

  • Manage Financial Conflicts of Interest (FCOI) prior to execution of an award or continuing review

  • Complete mandatory University training on Financial Conflicts of Interest (FCOI)


Forum for deans heads and chairs mitra dutta phd vice chancellor for research

Conflict of Interest

How to report and manage COI

Unit Executive Officer

  • Holds primary responsibility for working with the academic

    staff members to manage conflicts.

    UIC Conflict Review Committee (CRC)

  • Advisory to the Vice Chancellor for Research.

  • Reviews RNUA-management plans and other management plans as needed

    COI-Human Subject Research (COI-HSR) Committee

  • Expedited review of COI disclosures on IRB protocols

  • Makes recommendations to the IRB.


Forum for deans heads and chairs mitra dutta phd vice chancellor for research

Contact US

Jacquelyn Jancius, COI Director

Phone: 312-996-4070

Email: [email protected]

Scott MacEwen

COI Coordinator

Phone: 312-996-3642

Email: [email protected]

www.research.uic.edu/conflict


Research integrity

ResearchIntegrity


Forum for deans heads and chairs mitra dutta phd vice chancellor for research

Research misconduct at top-tier research institutions

raise public concerns about policing scientific integrity

  • 1970s

  • William Summerlin, Memorial Sloan-Kettering Cancer Center

  • the painted mice

  • 1980

  • Elias Alsabati, six different US research intitutions

  • >80 plagiarized and fraudulent papers

  • Marc Straus, Boston University

  • falsified patient eligibility for clinical trials

  • Vijay Soman, Yale Medical School

  • falsified and fabricated data

  • plagiarized a rival’s paper

  • John Long, Massachusetts General Hospital

  • falsely represented monkey cells as human


Forum for deans heads and chairs mitra dutta phd vice chancellor for research

Fraud in Biomedical Research

March 1981 Congressional Oversight Hearings

Al Gore, Jr. , Chair, Investigations and Oversight Committee

of the House Science and Technology Committee

Philip Handler, President of NAS:

“The system succeeds in policing itself”

Donald Frederickson, Director of NIH:

[no congressional mandate for regulation of research]…is necessary,

for the natural sciences contain ultimate correctives for any debasement

of the knowledge derived from research.”


Integrity in research and publication

Integrity in Research and Publication

  • Goal

    promote compliance with the highest scholarly standards

  • Purpose

    provide impartial fact-finding and fair adjudication of allegations of research misconduct

  • Policy

    UI Policy and Procedures on Integrity in Research and Publication

    http://www.vpaa.uillinois.edu/policies/Integrity-Policy.pdf

    UI Policy incorporates federal regulations and PHS guidelines

    42 CFR 93 (rev. 2005)

    http://www.gpo.gov/fdsys/pkg/CFR-2006-title42-vol1/pdf/CFR-2006-title42-vol1-part93.pdf


Forum for deans heads and chairs mitra dutta phd vice chancellor for research

  • 1985 Health Research Extension Act (Section 493)

  • HHS regulation requires that institutions establish:

    • process to review allegations research misconduct

    • report investigation of alleged research misconduct to the federal government


Integrity in research and publication1

Integrity in Research and Publication

Research Misconduct includes fabrication, falsification, or plagiarism in proposing, performing, or reviewing research, or in reporting research results.

  • Fabrication: making up data or results and recording or reporting them

  • Falsification: manipulating research materials, equipment, or processes,

    or changing or omitting data or results such that the research is not

    accurately represented in the research record.

  • Plagiarism: appropriation of another person’s ideas, processes, results

    or words without giving appropriate credit

  • Does not include honest error or difference of opinion


Integrity in research and publication2

Integrity in Research and Publication

Research Misconduct also includes, but is not limited to, the following:

  • intentionally misleading or deliberately false reporting of credentials

    and related information

  • abuse of confidentiality with respect to unpublished materials

    • misappropriation of research materials

    • evasion, or intentional failure to comply after notice with research

      regulations, such as those governing conflict of interest/commitment,

      human subjects, laboratory animals, new drugs, radioactive materials,

      genetically altered organisms, and safety

    • any other conduct that constitutes a serious deviation from accepted

      ethical guidelines and professional standards in scholarship

      and research


Integrity in research and publication3

Integrity in Research and Publication

  • Any member of the University community who has information

    related to potential Research Misconduct has a duty to report such

    information to the Respondent’s Unit Executive Officer, or to the RIO

  • Members of the University community shall cooperate with the RIO

    and other institutional officials in the review of allegations and the

    conduct of inquiries and Investigations.

  • Institutional members, including Respondents, have an obligation to

    provide evidence relevant to Research Misconduct allegations to the

    RIO or other institutional officials.


Forum for deans heads and chairs mitra dutta phd vice chancellor for research

Contact US

Mark D. Grabiner, PhD

Associate Vice Chancellor for Research and Research Integrity Officer

Phone: 312-996-2757

Email: [email protected]

Website: www.vpaa.uillinois.edu/Policies/integrityresearch/index.cfm


Research resources center rrc

Research Resources Center (RRC)


Forum for deans heads and chairs mitra dutta phd vice chancellor for research

  • Assures accessibility of shared resources to all researchers in the UIC community

  • Serves >1,000 investigators, $160M 013 grants

  • $8 M operating budget, 35-40% subsidy

  • 60 staff; full-time PhD lab directors in each facility

  • Faculty Academic Directors

  • East and West Campus central facilities


Forum for deans heads and chairs mitra dutta phd vice chancellor for research

Contact US

William Hendrickson

Director, RRC

Phone: 312-996-5600

Email: [email protected]

Website: http://www.rrc.uic.edu/


Biologic resources laboratory brl

Biologic Resources Laboratory(BRL)


Biologic resources laboratory

Biologic Resources Laboratory

  • UIC’s Centralized Animal Research Facility

  • Oversight of the institution’s animal care and use program

    • Support research

    • Daily care and husbandry of all laboratory animals

    • Procurement of all animals

    • Ensure animal welfare

    • Ensure compliance with regulatory agencies

    • Ensure the health status of animal colonies

    • Train students, staff, and faculty


Biologic resources laboratory1

Biologic Resources Laboratory

  • UIC’s Animal Care and Use Program has been continually accredited by AAALAC International since 1970.

  • Oldest and most successful training programs for laboratory animal veterinarians

  • Active professional staff

    • Professional organizations

    • Teaching

    • Research

    • Service


Biologic resources laboratory program scope

Biologic Resources LaboratoryProgram Scope

  • 137,000 sq. ft.

  • 10 satellite facilities

  • House over 20 species

  • Ave. daily census 32,000 animals

    • Mice 30,000

    • Primates 175


Biologic resources laboratory program scope1

Biologic Resources LaboratoryProgram Scope

  • Staff - 64

    • 11 vets – 5 board certified, 6 post-docs

    • 8 veterinary technicians

    • 37 husbandry staff

    • 6 administrative staff

    • 1enrichment specialist

    • 1 machinist


Biologic resources laboratory animal based research scope

Biologic Resources LaboratoryAnimal Based Research Scope

  • 275 investigators

  • 700 active research protocols

  • Types of studies

    • Cancer

    • Immunotherapy

    • Radiobiology

    • Infectious disease

    • TransplantationHeart Disease

    • Diabetes

    • Neurologic disease

    • Retinal diseases


Biologic resources laboratory2

Biologic Resources Laboratory

  • Main phone number 312-996-7040

  • Website http://www.brl.uic.edu/

    • Key contacts

    • Fee schedule

      • Animal per diem rate

      • Diagnostic lab services

      • Surgery services

  • Jeffrey Fortman, Director Biologic Resources Lab

    • 312-996-1220

    • [email protected]


  • Questions

    Questions?


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