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Peak Scientific Instruments Ltd

Peak Scientific Instruments Ltd. HOW DO I CHOOSE THE RIGHT GAS MANAGEMENT SYSTEM? What are the possible sources of gas? Who has experience about Gas Management Systems and can advise me? What information do I need about LC/MS Gas requirements and where will I find it?

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Peak Scientific Instruments Ltd

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  1. Peak Scientific Instruments Ltd • HOW DO I CHOOSE THE RIGHT GAS MANAGEMENT SYSTEM? • What are the possible sources of gas? • Who has experience about Gas Management Systems and can advise me? • What information do I need about LC/MS Gas requirements and where will I find it? • What are the decisions I need to make? • Which one will be best for my lab / my LCMS system(s)? • Are there any other considerations I should think about? • Who will install the gas management system? • What if I have problems and it stops working? • How much will it cost to run?

  2. Peak Scientific Instruments Ltd • WHAT ARE THE POSSIBLE SOURCES OF GAS? • In house gas already available • Liquid Nitrogen Dewar • Cylinder gas • Industrial gas generator • Laboratory gas generator • .

  3. Peak Scientific Instruments Ltd • WHO HAS EXPERIENCE ABOUT GAS MANAGEMENT SYSTEMS AND CAN ADVISE ME? • Colleague with LC/MS experience • Company preference already in place • LC/MS user group • Local guru or expert in country • Personal knowledge/experience • Technical publications • Internet - Google • LC/MS supplier • Gas management system supplier.

  4. Peak Scientific Instruments Ltd SUMMARY OF GAS SOURCES AND INFORMATION RECOMMENDATIONS ALTERNATIVES IN HOUSE GAS DEWAR CYLINDER LABORATORY GAS GENERATOR INDUSTRIAL GAS GENERATOR COLLEAGUE COMPANY PREFERENCE LC/MS USER GROUP LOCAL GURU OR EXPERT PERSONAL KNOWLEDGE END USER CHOICES LCMS MANUFACTURER

  5. Peak Scientific Instruments Ltd • WHAT INFORMATION DO I NEED ABOUT LC/MS • GAS REQUIREMENTS AND WHERE WILL I FIND IT? • Consult the LCMS manufacturer/gas supplier • Confirm the gas requirements (nitrogen, air, other?) • Confirm the required specifications for flow and pressure • Are there any other special gas requirements? • Consult the LCMS site prep guide if available • Is there a defined level of noise acceptable in the laboratory • NOW YOU HAVE A GOOD IDEA OF WHAT YOU REQUIRE • .

  6. Peak Scientific Instruments Ltd • WHICH GAS MANAGEMENT SYSTEM WILL BE BEST FOR MY LAB AND MY LCMS SYSTEMS? • In house gas • Liquid Nitrogen Dewar • Cylinder gas • Industrial gas generator • Laboratory gas generator • SO HOW DO I DECIDE WHICH ONE?

  7. Peak Scientific Instruments Ltd WHAT ARE THE DECISIONS I NEED TO MAKE? • “What is right for the application and your lab?” • Stand alone gas generator for each LCMS in lab (using existing house air)? • Stand alone gas generator with separate external air compressor? • Laboratory gas generator with built in compressors for each LCMS ? • How many LCMS systems will require gas? • Is this likely to change (increase) in the near future? • If more than one LCMS, will they all have the same gas requirements? • Are they located in the same area/laboratory? • What are the distances from generator to LCMS? • Are there any special Health & Safety Regulations to be considered? • NOW YOU KNOW WHAT DECISIONS NEED TO BE MADE!

  8. Peak Scientific Instruments Ltd USING EXISTING HOUSE AIR SUPPLY . CAUTION! • If you select a gas generator for use with an existing house air supply, make sure the air is of good quality and has the capacity to supply the correct flow and pressure to the gas generator. • You must also ensure that the air supply will not contaminate the generator or the LC/MS System – it must be • Clean, Dry and Oil – free • The generator should only ever be connected to a clean, dry and oil-free source of compressed air. If in any doubt, do not use this source of air. • A regulated minimum pressure of 120 psig is required for the generator to operate correctly. • NB. Contaminated air supplies are a common source of problems!

  9. Peak Scientific Instruments Ltd USING EXISTING OR NEW PIPEWORK? . CAUTION! • Is the generator to be connected to existing or new pipework? • If you plan to use existing pipework, has it been pressure/leak tested by a competent, qualified technician? • Can you guarantee that it is clean and free of contaminants? • What is the i.d/o.d of the tubing? • Do you know which material the tubing is made from? • If in any doubt, do not use this existing pipework – use new tubing of the correct internal diameter and material type. • NB. Contaminated pipework is a common source of problems!

  10. Peak Scientific Instruments Ltd WHICH GAS MANAGEMENT SYSTEM WILL BE BEST FOR MY LAB AND MY LCMS SYSTEMS? • In house gas x • Liquid Nitrogen Dewar x • Cylinder gas x • Industrial gas generator √ • Laboratory gas generator √ • So if I choose a generator, what are the options and how do I decide which is best for me?

  11. Peak Scientific Instruments Ltd SO HOW DO I DECIDE WHICH GENERATOR? Let me show you five gas generator possibilities: Single LC/MS gas generator With internal (built-in) compressors With separate air compressor system With separate air system and possibility to upgrade Multi LC/MS gas generator With separate air system and individual nitrogen generators (one for each LCMS system) With separate air system and one high capacity nitrogen generator (enough to supply all systems running at full flow simultaneously)

  12. Peak Scientific Instruments Ltd SINGLE LCMS SYSTEM NITROGEN GENERATOR WITH INTERNAL COMPRESSORS N2

  13. Peak Scientific Instruments Ltd SINGLE LCMS SYSTEM NITROGEN GENERATOR AIR COMPRESSOR N2 AIR

  14. Peak Scientific Instruments Ltd SINGLE LCMS SYSTEM WITH POSSIBLITY OF FUTURE UPGRADE AIR N2

  15. Peak Scientific Instruments Ltd AIR N2 MULTI LCMS SYSTEM WITH POSSIBLITY OF FUTURE UPGRADE

  16. Peak Scientific Instruments Ltd MULTI LCMS SYSTEMS WITH POSSIBLITY OF FUTURE UPGRADE

  17. Peak Scientific Instruments Ltd WHAT DO GAS GENERATORS LOOK LIKE? NM30L NM30LA N110DR Can be wall mounted or floor standing Floor standing Floor standing – fits under most standard lab benches THESE ARE ALL DESIGNED FOR SINGLE LC/MS SYSTEMS AND ARE INTENDED TO BE LOCATED CLOSE TO THE INSTRUMENTS IN THE LAB

  18. Peak Scientific Instruments Ltd • ARE THERE ANY OTHER CONSIDERATIONS? • General Surrounding Environment • Location – Free Air Space • Temperature (5-25°C for internal compressors) • Air Conditioning on 24/7? • Relative Humidity – Max 70% • Altitude – Max 2000 metres • Electrical requirements – 230V ± 10% (50/60Hz) • Local Health & Safety Regulations • Noise <59dB (A) for internal compressors • Maximum outlet pressure is 100psi

  19. Peak Scientific Instruments Ltd • WHO WILL INSTALL THE GAS MANAGEMENT SYSTEM? • This will vary from country to country • Always make sure you know your responsibilities • Refer to the site prep guides from the manufacturer(s) • Check that there are no health & safety obstacles • Inform FM people and anyone likely to be affected • Fulfil those commitments prior to installation • Agree what has to be done with the installation engineer • Set clear expectations – no surprises • Carry out an operational check with the engineer • Ensure everything works prior to engineer departing

  20. Peak Scientific Instruments Ltd • WHAT IF THE GENERATOR STOPS WORKING? • You need to think ahead how you will maintain your system • What is your anticipated usage? • What is the required uptime? • How many PMs will be required annually? • Will you buy multiple years service up front? • Is there a special budget required? • Is a service plan good value for money versus a dewar? • What is the return on investment over 5 years? • Can I work on a time and materials basis?

  21. Peak Scientific Instruments Ltd • WHAT IF THE GENERATOR STOPS WORKING? • Peak Scientific service plans available to purchase along with generator or retrospectively • Peak Scientific takes full responsibility for all generator service • All work carried out by Peak Scientific engineers • Priority response for clinical customers or customers with Peak Scientific complete service plan or warranty • Normally within 48 hours or sooner depending on customer location • Peak has >99% first time fix rate within 48 hours

  22. Peak Scientific Instruments Ltd • HOW MUCH WILL A GAS GENERATOR COST TO RUN?

  23. Peak Scientific Instruments Ltd

  24. Peak Scientific Instruments Ltd • THE DESIGN OF LC/MS SYSTEMS CONTINUES TO EVOLVE VERY RAPIDLY AND THEY ALL HAVE DIFFERENT GAS REQUIREMENTS • Scientists are continually looking for • Better qualitative and quantitative performance • More sensitivity • Improved resolution • Better productivity and efficiency • New LCMS models are introduced every year • This often means Peak Scientific needs to produce a new generator to match the needs of the latest LCMS system

  25. Peak Scientific Instruments Ltd • THE PEAK SCIENTIFIC APPROACH TO GAS GENERATORS FOR LC/MS • Which LCMS manufacturer and model? • Designs and specifications vary from model to model and so do the gas requirements! • What is the type of instrument? • Single or triple quad, TOF etc...? • What is the application – ESi or APCi or both? • In summary – • The Peak Scientific approach is to design and manufacture bespoke generators which exactly match the gas requirements of the mass spectrometer application

  26. Peak Scientific Instruments Ltd • GAS GENERATORS – OUR ONLY BUSINESS • Bespoke gas generators for the analytical instrument industry • Mainly supplying generators for LCMS & GC instruments • So Peak is a niche market supplier to those OEMs • Peak manufactures high purity nitrogen, hydrogen and zero air generators as well as some others for TOC, purge gas and calibration gas applications • Our main focus is on supplying quality products backed up with worldwide service and support • And of course, most important of all, as a specialist company in the gas generator market, we are proud of our reputation for first class CUSTOMER SATISFACTION ..................wherever you are

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