Thyroid Diseases. Steve Orme Leeds. Introduction. Background Basic Principles Clinical Syndromes Summary. Hypothesis Testing?. Appreciate Limitation of Laboratory Investigations Treat ‘Normal Ranges’ with the Disdain they Deserve Avoid Medicine by Proxy Do not Over Investigate.
CBZ Plasma T 1/2 6-8 Hrs Crosses Placenta & Breast Epithelium >10 more Potent than PTU Duration of Action >24 Hrs
PTU Plasma T 1/2 1-2 Hrs Minimal Placental & Breast Transfer
Duration of Action 12-24 HrsGraves DiseasePharmacology of CBZ/PTU
Type I Goitre Present Iodine Uptake & Colour Flow Doppler Increased
Type II No Small/Goitre Inflammatory Markers Increased Low Iodine uptake and Colour Flow Doppler Subsequent HypothyroidismAmiodarone Induced Thyrotoxicosis
Type I Carbimazole Potassium Perchlorate Radioactive Iodine Surgery
Type II Prednisolone SurgeryAmiodarone Induced Thyrotoxicosis