Action Potential Types
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Action Potential Types. Fast- and Slow Response Action Potentials. Slow response: Ionic currents. Why slow response?. High dv/dt: >200 V/s High conduction velocity: 1-4 m/s Specific drug sensitivity: sodium channel blockers – (lidocaine) and tetrodotoxin. Low dv/dt: < 20 V/s

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Action Potential Types

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Action Potential Types


Fast- and Slow Response Action Potentials


Slow response: Ionic currents

Why slow response?


High dv/dt: >200 V/s

High conduction velocity: 1-4 m/s

Specific drug sensitivity: sodium channel blockers –

(lidocaine) and tetrodotoxin

Low dv/dt: < 20 V/s

Low conduction velocity: 0.02-0.05 m/s

Specific drug sensitivity: calcium channel blockers –

nifedipine, verapamil

Spontaneous phase 4 depolarization

Fast response: Atria Slow response: Ventricles, Purkinje Fibers. SAN, AVN


Automaticity

Pacemakers hierarchy:

SAN,AVN, Purkinje fibers


Why are fibers of the conducting system automatic?

Membrane potential of SA nodal cells


Pacemaker Frequency - Mechanisms


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