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TREATMENT OF DEPRESSION IN THE ELDERLY. Jackie L. Neel, D.O. OSU Center for Health Sciences College of Osteopathic Medicine (Revised 9/2002). “It is not enough for a great nation merely to have added new years to life--our objective must also be to add new life to those years.”.

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Treatment of depression in the elderly

TREATMENT OF DEPRESSION IN THE ELDERLY

Jackie L. Neel, D.O.

OSU Center for Health Sciences

College of Osteopathic Medicine

(Revised 9/2002)


“It is not enough for a great nation merely to have added new years to life--our objective must also be to add new life to those years.”

---John F. Kennedy

Depression of the Elderly - - Jackie L. Neel, D.O.


Our population is aging
Our population is Aging! new years to life--our objective must also be to add new life to those years.”

  • 2/3 of all the people in the history of the world who have reached age 65 are alive today!

  • 1/2 the women who are 65 today will survive to age 85.

  • 1980-1990 population over 85 increased by 40%; centenarians doubled.

  • Avg. lifespan in 1900=47, today=75

Depression of the Elderly - - Jackie L. Neel, D.O.


Healthy functioning older adults are at no greater risk for depression than younger adults
Healthy functioning older adults are at no greater risk for depression than younger adults

Depression of the Elderly - - Jackie L. Neel, D.O.


Risk factors
Risk Factors depression than younger adults

  • Depression increases in the elderly due to:

    • Multiple losses

    • Medical illness

    • Cognitive dysfunction

  • The greatest risk factor for depression in the elderly is history of previous depression

Depression of the Elderly - - Jackie L. Neel, D.O.


Compounding of adverse life events in aging

Jobs depression than younger adults

Money

Homes

Friends

Abilities

Health

Hopes

Bereavement

Compounding of Adverse Life Events in Aging

Depression of the Elderly - - Jackie L. Neel, D.O.


Prevalence of depression in medical illness
Prevalence of Depression in Medical Illness depression than younger adults

Stroke 26-61%

Cancer 18-39%

Myocardial infarct 15-19%

Rheumatoid Arthritis 13%

Parkinson’s Disease 10-37%

Diabetes 5-11%

Depression of the Elderly - - Jackie L. Neel, D.O.


Categories of medical problems in elderly inpatients with major depression
Categories of Medical Problems in elderly inpatients with Major Depression

Circulatory 69%

Digestive 61%

Endocrine, metabolic 45%

Other 25%

Genitourinary 24%

Mean # of medical problems = 5

Depression of the Elderly - - Jackie L. Neel, D.O.


Common secondary causes of depression in the elderly

Alzheimer’s Major Depression

Vascular and other dementia

Common infections (i.e. pneumonia or UTI)

Substance abuse

Endocrine disorders

Electrolyte imbalance

Tumor

Endocrine

Prescription meds

Common Secondary Causes of Depression in the Elderly

Depression of the Elderly - - Jackie L. Neel, D.O.


Dementia and depression
Dementia and Depression Major Depression

  • Alzheimer’s - 20-40%

  • Similar rates with other dementia's

    • Vascular

    • Parkinson’s

    • Huntington’s

    • Brain injury

    • B12,folate

  • Depression may precede other symptoms

Depression of the Elderly - - Jackie L. Neel, D.O.


Having a mental disorder in late life increases mortality by 1 6 2 5 times
Having a mental disorder in late life increases mortality Major Depressionby 1.6 - 2.5 times

Depression of the Elderly - - Jackie L. Neel, D.O.


Rates of mi are 4 5 times greater in patients with history of major depression
Rates of MI are 4.5 times greater in patients with history of major depression

Depression of the Elderly - - Jackie L. Neel, D.O.


Suicide
Suicide of major depression

  • 15% of severely depressed persons commit suicide

  • Elderly white males are at greatest risk

  • 80% consult physician in the month before death

  • Elderly are less likely to have had previous attempts or to complain of suicidal thoughts--more likely to complete it.

Depression of the Elderly - - Jackie L. Neel, D.O.


Suicide cont
Suicide, of major depressioncont.

  • 10 years after stroke

    • Mortality for non-depressed is 40%

    • Mortality for depressed is 70%

Depression of the Elderly - - Jackie L. Neel, D.O.


Diagnosing depression in the elderly

DSM-IV criteria may not be met of major depression

Deny most mood symptoms, but may appear fearful or sad

Loss of interest in usual activities

Irritable, brooding

Somatic

Diagnosing Depression in the Elderly

Depression of the Elderly - - Jackie L. Neel, D.O.


Diagnosing depression in the elderly cont

DSM-IV criteria may not be met of major depression

Sleep and appetite changes

Fatigue

Less suicidal complaints, but highest rate in elderly males

Social withdrawal

Diagnosing Depression in the Elderly, cont.

Depression of the Elderly - - Jackie L. Neel, D.O.


The diagnosis of depression in the elderly is often missed
The Diagnosis of Depression in the Elderly is Often Missed of major depression

  • Sx of medical illness may be the same as depression

    • low energy

    • loss of interest

    • anorexia

    • fatigue

Depression of the Elderly - - Jackie L. Neel, D.O.


The diagnosis of depression in the elderly is often missed cont
The Diagnosis of Depression in the Elderly is Often Missed, of major depressioncont.

  • Study at Duke University

    • Assessment given to elderly medical admits

    • Of those meeting criteria for depression, only 40.5% received an anti-depressant

Depression of the Elderly - - Jackie L. Neel, D.O.


Pseudodementia
Pseudodementia of major depression

  • Cognitive problems related to depression

  • Higher incidence of development of dementia

  • Past hx of mood disorder

  • Depressive sx precede cognitive sx

  • Acute onset

  • Increase in dependency

Depression of the Elderly - - Jackie L. Neel, D.O.


Pseudodementia cont
Pseudodementia, of major depressioncont.

  • Slow psychomotor response,low motivation and social interaction

  • Improve with antidepressant

  • Better to risk over-diagnosis and treat for depression

  • Use clinical judgement based on patient history and function

Depression of the Elderly - - Jackie L. Neel, D.O.


Treatment of depression in the elderly1
Treatment of Depression in the Elderly of major depression

  • Treat co-morbid conditions and etiologies of secondary depression

  • Choose appropriate level of care

  • Keep in mind that suicide occurs more in elderly than in any other age group

  • Choose therapies appropriate to age and cognitive functioning

  • Psychosocial interventions

Depression of the Elderly - - Jackie L. Neel, D.O.


Watch for signs of elder abuse and neglect
Watch for Signs of Elder Abuse and Neglect of major depression

  • Malnutrition and dehydration

  • Bruises, fractures, burns

  • Mental abuse

  • Neglected medical care

  • Sexually transmitted diseases

Depression of the Elderly - - Jackie L. Neel, D.O.


Pharmacology
Pharmacology of major depression

START LOW -- GO SLOW

Depression of the Elderly - - Jackie L. Neel, D.O.


Pharmacologic complications in the elderly
Pharmacologic Complications in the Elderly of major depression

  • Pharmacokinetics

  • Pharmacodynamics

  • End-organ physiological change

  • Medical illness

  • Cognitive decline

  • Polypharmacy

  • Compliance

  • Life adversity

Depression of the Elderly - - Jackie L. Neel, D.O.


Pharmacokinetics and the elderly
Pharmacokinetics and the Elderly of major depression

  •  Gastric motility and pH

    • Causes  absorption

  •  Fat/lean body ratio

    • Causes  volume of distribution and  half-life

  •  Hepatic blood flow

    • Causes  breakdown

Depression of the Elderly - - Jackie L. Neel, D.O.


Pharmacokinetics and the elderly cont
Pharmacokinetics and the Elderly, of major depressioncont.

  •  Activity of some catabolic enzymes

    • Causes  plasma levels and half-life

  •  GFR

    • Causes  clearance and  accumulation

Depression of the Elderly - - Jackie L. Neel, D.O.


Pharmacodynamics and the elderly
Pharmacodynamics and the Elderly of major depression

  • Increased sensitivity to:

    • Sedation

    • Cardiovascular effects

    • Anticholinergic effects

Depression of the Elderly - - Jackie L. Neel, D.O.


Noncompliance in the elderly
Noncompliance in the Elderly of major depression

  • 40-70% noncompliance

  • 10% take drugs prescribed for others

  • 20% take drugs not currently prescribed

  • 40% stop drugs too soon

Depression of the Elderly - - Jackie L. Neel, D.O.


Principles of pharmacologic treatment
Principles of Pharmacologic Treatment of major depression

  • Use medications with minimal Anticholinergic, cardiovascular and orthostatic effects

  • Begin with low dose

  • Monitor compliance

  • Monitor side effects

  • Increase dose slowly, but use adequate amounts

Depression of the Elderly - - Jackie L. Neel, D.O.


Use the more selective drugs with less side effects first
Use the More Selective Drugs with Less Side Effects First of major depression

  • Selective Serotonin Reuptake Inhibitor (SSRI)

    Fluoxetine (Prozac) 10-80 mg/d

    Fluvoxetine (Luvox) 25-250 mg/d

    Paroxetine (Paxil) 10-60 mg/d

    Sertraline (Zoloft) 25-200 mg/d

    Citalopram (Celexa) 25-200 mg/d

    Escitalopvam (Lexapro) 10-20 mg/d

    • Safe, effective

    • Side effects--Activation,GI, headache, sexual, enzyme inhibition (Cyt P450)

Depression of the Elderly - - Jackie L. Neel, D.O.


Use the more selective drugs with less side effects first cont
Use the More Selective Drugs with Less Side Effects First, of major depressioncont.

  • Serotonin Syndrome

    • Myoclonus, hyperreflexia, tremor

    • Confusion, agitation, hypomania

    • Fever, sweating, shivering

    • Diarrhea

  • Stop or reduce drug

  • Propranolol, clonazepam

Depression of the Elderly - - Jackie L. Neel, D.O.


Use the more selective drugs with less side effects first cont1
Use the More Selective Drugs with Less Side Effects First, of major depressioncont.

  • Venlafaxine (Effexor)

    • 12.5mg BID-350 mg/d, XR 37.5,75,150 mg/d

    • Reuptake inhibition of serotonin and norepinephrine

    • May be more efficacious in refractory cases and vegetative depression

    • Side effects--nausea, activation, serotonin syndrome, htn, tremor

Depression of the Elderly - - Jackie L. Neel, D.O.


Use the more selective drugs with less side effects first cont2
Use the More Selective Drugs with Less Side Effects First, of major depressioncont.

  • Nefazodone (Serzone)

    • 50-600 mg divided or HS q Day

    • Safe, anxiolytic, increases sleep, less sexual side effects

    • Side effects--dizziness,sedation, GI, CytoP450 inhibition

Depression of the Elderly - - Jackie L. Neel, D.O.


Use the more selective drugs with less side effects first cont3
Use the More Selective Drugs with Less Side Effects First, of major depressioncont.

  • Bupropion (Wellbutron)

    • 75-150 mg TID, SR 100-150 mg BID

    • Safe, effective, no sexual side effects, activation

    • Side effects--activation, GI, HA, Seizures

Depression of the Elderly - - Jackie L. Neel, D.O.


Use the more selective drugs with less side effects first cont4
Use the More Selective Drugs with Less Side Effects First, of major depressioncont.

  • Mirtazapine (Remeron)

    • 7.5-60 mg (sedating at the lower doses)

    • Safe, antidepressant, anti-anxiety, 1X/d

    • Helps sleep and appetite in elderly at low dose

    • Side effects--constipation, dizziness, dry mouth, somnolence

    • Agranulocytosis or neutropenia (rare)

Depression of the Elderly - - Jackie L. Neel, D.O.


Tricyclic antidepressants
Tricyclic Antidepressants of major depression

  • Effective antidepressants BUT avoid due to:

    • Orthostatic hypotension

    • Slow cardiac conduction

    • Increase HR

    • Decreased heart rate variability

    • Sedation

Depression of the Elderly - - Jackie L. Neel, D.O.


Tricyclic antidepressants cont
Tricyclic Antidepressants, of major depressioncont.

  • Effective antidepressants BUT avoid due to:

    • Sexual

    • Dry mouth

    • Constipation

    • Urinary retention

Depression of the Elderly - - Jackie L. Neel, D.O.


If other types of antidepressants fail
If other types of antidepressants fail: of major depression

  • Nortriptyline and desiprimine

    • Starting at low doses

    • Monitoring blood levels can be used

  • Trazodone (Desyrel)

    • Use for sleep in low doses--very high doses may be necessary for antidepressant effect

    • May lead to orthostasis

    • Less anticholinergic side effects.

Depression of the Elderly - - Jackie L. Neel, D.O.


If other types of antidepressants fail cont
If other types of antidepressants fail, of major depressioncont.

  • Psychostimulants

    • Ritalin--5mg q am-5-10 mg tid

    • Watch BP and HR

    • May cause psychosis

    • May mobilize the vegetatively depressed and medically ill

Depression of the Elderly - - Jackie L. Neel, D.O.


For depression with psychotic features
For depression with psychotic features: of major depression

  • Low doses of higher potency antipsychotics

    • .5 - 2 mg haloperidol (Haldol) will often suffice

    • 2.5 - 5 mg olanzepine (Zyprexa)

    • 25 mg quetiapine (Seroquel)

    • .25 - .5 mg risperidone (Risperdal)

    • May go higher if tolerated and no response at lower doses

Depression of the Elderly - - Jackie L. Neel, D.O.


For depression with psychotic features cont
For depression with psychotic features, of major depressioncont.

  • Mood Stabilizers

    • Lithium

    • Valproate (Depakote)

    • Carbemazepine (Tegretol)

  • Monitor blood levels

  • Liver enzymes for Depakote and Tegretol

  • CBC for Tegretol

  • TSH, Cr for Lithium

Depression of the Elderly - - Jackie L. Neel, D.O.


For depression with psychotic features cont1
For depression with psychotic features, of major depressioncont.

  • For agitation:

    • Lorazepam (Ativan) .5-1 mg TID PO or IM or IV

      • Increased risk for falls with use

Depression of the Elderly - - Jackie L. Neel, D.O.


Electroconvulsive therapy
Electroconvulsive Therapy of major depression

  • For depression which is:

    • Unresponsive to medication

    • With psychotic features

    • Putting the patient at risk due to poor oral intake or suicidality

  • More cardiac risks in the elderly, but can be performed safely

Depression of the Elderly - - Jackie L. Neel, D.O.


Psychotherapy

Problem Solving of major depression

Supportive

Cognitive Behavioral

Reminiscent

Pets

Touching

Education

Family

Groups

Psychosocial Intervention

Psychotherapy

Depression of the Elderly - - Jackie L. Neel, D.O.


Erikson s final stage of development
Erikson’s Final Stage of Development of major depression

  • Integrity Versus Despair and Isolation

  • Feeling life has been worthwhile and accepting your place in the life cycle

  • “Healthy children will not fear life if their parents have integrity enough not to fear death.”

Depression of the Elderly - - Jackie L. Neel, D.O.


References
References of major depression

  • Zisook, S, M.D., and Downs, N. S., M.D., Diagnosis and Treatment of Depression in Late Life, Journal of Psychiatry 1998;59 (suppl 4), pg. 80-91.

  • Medical Advances -- Health in Mind and Body, Vol. 2, No. 1

Depression of the Elderly - - Jackie L. Neel, D.O.


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