Poster Discussion III. Robert G. Maki, MD PhD Memorial Hospital New York, NY, USA. Focus on just a few of the quality posters from this session. Basic Science 34824 Leiomyosarcoma phosphokinome (El Sayadi) Neoadjuvant therapy
Robert G. Maki, MD PhD
New York, NY, USA
How do you distinguish aneuploid sarcomas of a given histology?
Fluellen: By your patience, Aunchient (Ensign) Pistol. Fortune is painted blind, with a muffler afore her eyes, to signify to you that Fortune is blind; and she is painted also with a wheel, to signify to you, which is the moral of it, that she is turning, and inconstant, and mutability, and variation: and her foot, look you, is fixed upon a spherical stone, which rolls, and rolls, and rolls: in good truth, the poet makes a most excellent description of it: Fortune is an excellent moral.
Can we use something other than RECIST to determine radiological outcome for sarcoma patients?
Median follow up 41.5 months (12-118).
n = 41 :
Stability in 4 (10%)
Median volume change: -19 cm3(-18%); mean +134 cm3 (+20%)
LR: 4 (2 responders, 2 progressors)
Mets: 8 (4 from each group)
Death: 8 (6 from progression group, 1 from response and 1 from stable group)
Patients with poor outcome had shorter OS than other two groups (p=0.02 Cox, p=0.005 K-M)
DFS similar for both groups (p~0.45-0.5)
Degree of tumor necrosis did correlate with outcome
*One outlier (85%,+931%) is not shown on the graph.
We’ve got the information, why not use it?!
Would be interesting to see sensitivity analysis to see how volume change (percentage) would affect these cutoffs
Correlation with PET or DCE MRI would also be intriguing
Ay, marry, now my soul hath elbow-room;
It would not out at windows nor at doors.
There is so hot a summer in my bosom,
That all my bowels crumble up to dust:
I am a scribbled form, drawn with a pen
Upon a parchment, and against this fire
Do I shrink up.
How quickly do GIST patients respond to imatinib in the neoadjuvant setting?
What are promising new combinations of targeted and cytotoxic systemic therapeutics?
[They play and Hamlet scores a hit]
What is the follow up on a promising proapoptotic antibody?
All’s Well that Ends Well, II, i (1602-03)
Romeo and Juliet, V, iii (1594-96, 1st perf. 1662)
What remains controversial regarding sarcoma management?
17 of 23 physicians queried had responded as to how best to treat 7 cm thigh pleomorphic RMS in adults
9 recommended extra staging beyond chest CT
13 recommended chemotherapy without a consistent regimen noted
RT suggested by 11
Not a lot of consensus!
Hippolyta: I was with Hercules and Cadmus once, When in a wood of Crete they bay'd the bear With hounds of Sparta: never did I hear Such gallant chiding: for, besides the groves, The skies, the fountains, every region near Seem'd all one mutual cry: I never heard So musical a discord, such sweet thunder.
Jaffe N and Gorlick R, JCO 2008; 26: 4365
WICHITA, KS, 4 November 2008—In a thrilling conclusion to one of the longest and most anticipated
elections in U.S. history, charismatic Democrat Alan Klemke defeated opponent Carl Ferguson
to become the new alderperson for Wichita's 4th District.
WASHINGTON, 6 November 2008—Reports surfaced Tuesday that the New York–based Fox News Channel has obtained a tape which purportedly features another cryptic video message from U.S. vice president and known extremist Dick Cheney, widely regarded as the most feared man in America.
Othello, III, iii (1604)
Othello: Excellent wretch! Perdition catch my soulBut I do love thee! and when I love thee not, Chaos is come again.
MacBeth, I, i (1605-06, 1st perf. 1611 Globe Theatre)
Sonnet XVIII (1609)
Shall I compare thee to a summer's day?
Thou art more lovely and more temperate:
Rough winds do shake the darling buds of May,
And summer's lease hath all too short a date:
Sometime too hot the eye of heaven shines,
And often is his gold complexion dimm'd;
And every fair from fair sometime declines,
By chance or nature's changing course untrimm'd;
But thy eternal summer shall not fade
Nor lose possession of that fair thou owest;
Nor shall Death brag thou wander'st in his shade,
When in eternal lines to time thou growest:
So long as men can breathe or eyes can see,
So long lives this and this gives life to thee.
Eden Roc Hotel
November 4 – 7, 2009