PH402

PH402 PowerPoint PPT Presentation


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PH402

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1. PH402 Hypertension and Antihypertensives Chris Hague, PhD [email protected] Technical Advisor: Seth Goldenberg, PhD

2. Brody’s Human Pharmacology, 4th Edition Guyton Human Physiology http://www.americanheart.org/presenter.jhtml?identifier=2152 http://www.nhlbi.nih.gov/health/dci/Diseases/Hbp/HBP_WhatIs.html References

10. 42,418 participants Findings: Chlorthalidone is superior to an ACE inhibitor, a calcium channel blocker and an alpha1-adrenergic antagonist in preventing one or more CVD events. Recommendations for antihypertensive treatment: Use Thiazide-type diuretics as first treatment in stage I and II hypertension prevent cardiovascular disease better than other classes lower cost drugs of choice for first-step antihypertensive therapy. Diuretic intolerant patients: consider Ca2+ channel blockers and ACE inhibitors Most hypertensive patients require more than one drug. Diuretics should generally be part of the antihypertensive regimen. Lifestyle advice should also be provided. http://www.nhlbi.nih.gov/health/allhat/index.htm

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