1. PH402 Hypertension and Antihypertensives Chris Hague, PhD
Technical Advisor: Seth Goldenberg, PhD
2. Brody’s Human Pharmacology, 4th Edition
Guyton Human Physiology
10. 42,418 participants
Findings: Chlorthalidone is superior to an ACE inhibitor, a calcium channel blocker and an alpha1-adrenergic antagonist in preventing one or more CVD events.
Recommendations for antihypertensive treatment:
Use Thiazide-type diuretics as first treatment in stage I and II hypertension
prevent cardiovascular disease better than other classes
drugs of choice for first-step antihypertensive therapy.
Diuretic intolerant patients: consider Ca2+ channel blockers and ACE inhibitors
Most hypertensive patients require more than one drug. Diuretics should generally be part of the antihypertensive regimen.
Lifestyle advice should also be provided.