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Pandemic Influenza Vaccine Distribution Selected Updates Pandemic Influenza Vaccine: Doses Administered and Safety Training Conference Toscha Stanley, MHSA Immunization Services Division Centers for Disease Control and Prevention (CDC) August 21, 2008 Vaccination periods

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Pandemic Influenza Vaccine Distribution Selected Updates

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Pandemic influenza vaccine distribution selected updates l.jpg

Pandemic Influenza Vaccine Distribution Selected Updates

Pandemic Influenza Vaccine:

Doses Administered and Safety Training Conference

Toscha Stanley, MHSA

Immunization Services Division

Centers for Disease Control and Prevention (CDC)

August 21, 2008


Vaccination periods l.jpg

Vaccination periods

  • Five vaccination periods (take into account both timing and supply)

    • Preparation period

    • Pre-pandemic influenza vaccination period

    • Manufacturing period

    • Early pandemic influenza vaccination period

    • Later pandemic influenza vaccination period


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Vaccine distribution

  • Initial demand expected to exceed supply

    • When (demand >>> supply): allocation “push” model

    • When (demand > supply): may transition to “pull” model

  • Vaccine distribution will be monitored via CDC’s FluFinder

  • States will be able to access FluFinder data for their individual state through the CDC secure data network


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Direct distribution

  • Manufacturer ships vaccine to states using its established distribution channels (commercial shipper or 3rd party distributor)

  • May involve single or multiple manufacturers depending on the current state of domestic manufacturing capacity


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Ship-to site 1

(50%)

Ship-to site 1

(60%)

POD

POD

POD

POD

POD

POD

Ship-to site 2

(25%)

Ship-to site 2

(30%)

POD

POD

POD

POD

POD

POD

Ship-to site 3

(10%)

Ship-to site 3

(25%)

POD

POD

POD

POD

POD

POD

State B (2% of U.S. supply)

State A (4% of U.S. supply)

Vaccine manufacturer A

Needle/syringe manufacturer

CDC and HHS

Vaccine manufacturer B

3rd party distributor

Direct distribution: Pre-pandemic influenza vaccine distribution with multiple manufacturers jointly supplying states


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Ship-to site 1

(50%)

Ship-to site 1

(60%)

POD

POD

POD

POD

POD

POD

Ship-to site 2

(30%)

Ship-to site 2

(25%)

POD

POD

POD

POD

POD

POD

Ship-to site 3

(10%)

Ship-to site 3

(25%)

POD

POD

POD

POD

POD

POD

State A (4% of U.S. supply)

State B (2% of U.S. supply)

CDC and HHS

Needle/syringe manufacturer

Vaccine manufacturer A

Direct distribution: Pandemic influenza vaccine distribution with a single manufacturer


Operations at the state level l.jpg

Operations at the state level

  • State-designated ship-to sites must be capable of:

    • Receiving

    • Storing

    • Securing

    • Repackaging

    • Allocating to PODs

    • Follow-on distribution to PODs

  • Allocation, distribution, and administration within a state will be a state and local function


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Ship-to sites

  • Total # of Pre-pandemic vax ship-to sites = 623

  • Total # of Pandemic vax ship-to sites = 976

    1 site2-10 sites>10 sites

    Pre-Pandemic 43 9 10

    Pandemic 38 8 16

  • Federal ship-to sites


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POD 1

POD 2

Single central

ship-to site

Vaccine, adjuvant, needles and syringes

POD 3

POD 4

POD 5

State X: Single central ship-to site with direct shipment to PODs


Slide10 l.jpg

POD 1

Regional

sub-ship-to site #1

POD 2

Vaccine manufacturer or distributor

Single Central

ship-to site

POD 3

POD 4

Regional

Sub-ship-to site #2

POD 5

State Z: Single ship-to site with regional sub-ship-to sites within the state


Slide11 l.jpg

POD 1

Ship-to site

#1

POD 2

Ship-to site

#2

Vaccine, adjuvant, needles and syringes

POD 3

POD 4

Ship-to site

#3

POD 5

State Y: Multiple ship-to sites with direct shipment to PODs


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The findings and conclusions in this presentation have not been formally disseminated by CDC and should not be construed to represent any agency determination or policy.


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Extra Slides


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Ship-to site 1

(50%)

Ship-to site 1

(60%)

POD

POD

POD

POD

POD

POD

Ship-to site 2

(25%)

Ship-to site 2

(30%)

POD

POD

POD

POD

POD

POD

Ship-to site 3

(10%)

Ship-to site 3

(25%)

POD

POD

POD

POD

POD

POD

State A (4% of U.S. supply)

State B (2% of U.S. supply)

Centralized Distribution Option

Vaccine manufacturer A

CDC and HHS

Central distributor

Needle/syringe manufacturer

Vaccine manufacturer B

Centralized distribution: Multiple manufacturers and multiple products


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