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MRI Infusion Pump. Advisor Dr. Naomi Chesler. Biomedical Engineering University of Wisconsin - Madison. Group Members. Ryan Augustine Gordy Lawrence Tim Eng Christine Weisshaar Megan Buroker Nate Gaeckle. Client. Dr. George C. Newman Department of Neurology

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Advisor dr naomi chesler l.jpg
AdvisorDr. Naomi Chesler

  • Biomedical Engineering

  • University of Wisconsin - Madison


Group members l.jpg
Group Members

  • Ryan Augustine

  • Gordy Lawrence

  • Tim Eng

  • Christine Weisshaar

  • Megan Buroker

  • Nate Gaeckle


Client l.jpg
Client

  • Dr. George C. Newman

  • Department of Neurology

  • University of Wisconsin Hospital


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The goal of this design is to create a more time efficient pump that wastes a smaller amount of gadolinium and infuses with controllable precision. A prototype has been constructed that uses Bernoulli’s principle of ideal fluid flow. This prototype will be able to deliver a bolus injection, immediately followed by the infusion, while also having the ability to change the flow rates of gadolinium and saline throughout the infusion. This will save both time during the procedure, and money expended on gadolinium. The design is still in the beginning stages, and there are a few modifications and additions to be made to have a device that can be used accurately in an MRI environment.


Background l.jpg
Background pump that wastes a smaller amount of gadolinium and infuses with controllable precision. A prototype has been constructed that uses Bernoulli’s principle of ideal fluid flow. This prototype will be able to deliver a bolus injection, immediately followed by the infusion, while also having the ability to change the flow rates of gadolinium and saline throughout the infusion. This will save both time during the procedure, and money expended on gadolinium. The design is still in the beginning stages, and there are a few modifications and additions to be made to have a device that can be used accurately in an MRI environment.

  • Contrast agent gadolinium infused in blood stream to create diagnostic image.

  • Infusion pump holds syringe of gadolinium and syringe of saline rinse.

  • Pump connected to patient’s IV line.

  • Magnetic field requires materials be non-ferrous

  • Gadolinium is pre-packaged.

    • Waste $40. per bottle


Motivation l.jpg
Motivation pump that wastes a smaller amount of gadolinium and infuses with controllable precision. A prototype has been constructed that uses Bernoulli’s principle of ideal fluid flow. This prototype will be able to deliver a bolus injection, immediately followed by the infusion, while also having the ability to change the flow rates of gadolinium and saline throughout the infusion. This will save both time during the procedure, and money expended on gadolinium. The design is still in the beginning stages, and there are a few modifications and additions to be made to have a device that can be used accurately in an MRI environment.

  • Our client desires a controllable device for bolus and infusion during MRI scans that is durable enough for daily use. Inaccurate flow rates and quantities can lead to diagnostic errors.


Client requirements l.jpg
Client Requirements pump that wastes a smaller amount of gadolinium and infuses with controllable precision. A prototype has been constructed that uses Bernoulli’s principle of ideal fluid flow. This prototype will be able to deliver a bolus injection, immediately followed by the infusion, while also having the ability to change the flow rates of gadolinium and saline throughout the infusion. This will save both time during the procedure, and money expended on gadolinium. The design is still in the beginning stages, and there are a few modifications and additions to be made to have a device that can be used accurately in an MRI environment.

  • Current MRI pumps are restricted in flow rate control and waste considerable contrast. Manual syringe loading costs time between bolus and infusion, leading to image inaccuracy. The client desires a pump that can control the flow rates of both contrast and saline, without having to constantly change the syringes. Due to the magnetic field, this pump must be made from non-ferrous material.


Design requirements l.jpg
Design Requirements pump that wastes a smaller amount of gadolinium and infuses with controllable precision. A prototype has been constructed that uses Bernoulli’s principle of ideal fluid flow. This prototype will be able to deliver a bolus injection, immediately followed by the infusion, while also having the ability to change the flow rates of gadolinium and saline throughout the infusion. This will save both time during the procedure, and money expended on gadolinium. The design is still in the beginning stages, and there are a few modifications and additions to be made to have a device that can be used accurately in an MRI environment.

  • Flow rate ranges from 0.25 to 5 mL/sec

  • Overcome venous pressure of 15 mmHg

  • Decrease time between bolus and infusion

  • Non-ferrous material.

  • Bolus: deliver 10-25 mL +- 0.5 mL contrast at 3mL/s +- 0.2 mL/sec

  • Infusion: (within 0.02 mL/sec)

    • Deliver contrast at 0.25-0.35 mL/sec

    • Deliver saline at 0.65-0.75 mL/sec


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  • Bernoulli’s Equation for steady Flow pump that wastes a smaller amount of gadolinium and infuses with controllable precision. A prototype has been constructed that uses Bernoulli’s principle of ideal fluid flow. This prototype will be able to deliver a bolus injection, immediately followed by the infusion, while also having the ability to change the flow rates of gadolinium and saline throughout the infusion. This will save both time during the procedure, and money expended on gadolinium. The design is still in the beginning stages, and there are a few modifications and additions to be made to have a device that can be used accurately in an MRI environment.

    P1 = P2 + (1/2)ρQ22(1/A22 – 1/A12) + ρgΔh

  • Bernoulli’s Equation for unsteady Flow

    P1 = P2 + (1/2)ρQ22(1/A22 – 1/A12) + ρgΔh + ∫(dvs/dt)ds


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Final Design pump that wastes a smaller amount of gadolinium and infuses with controllable precision. A prototype has been constructed that uses Bernoulli’s principle of ideal fluid flow. This prototype will be able to deliver a bolus injection, immediately followed by the infusion, while also having the ability to change the flow rates of gadolinium and saline throughout the infusion. This will save both time during the procedure, and money expended on gadolinium. The design is still in the beginning stages, and there are a few modifications and additions to be made to have a device that can be used accurately in an MRI environment.

  • Follows Bernoulli’s Equation for Ideal Fluid Flow

  • Made for 250 mL IV bags.

  • Pump made from polycarbonate and brass fittings.

  • Rubber Gasket used to seal the pump.

  • ~$5000 for final design.


Future work l.jpg
Future Work pump that wastes a smaller amount of gadolinium and infuses with controllable precision. A prototype has been constructed that uses Bernoulli’s principle of ideal fluid flow. This prototype will be able to deliver a bolus injection, immediately followed by the infusion, while also having the ability to change the flow rates of gadolinium and saline throughout the infusion. This will save both time during the procedure, and money expended on gadolinium. The design is still in the beginning stages, and there are a few modifications and additions to be made to have a device that can be used accurately in an MRI environment.

  • Addition of Ultrasonic flowmeters to IV lines.

  • Addition of pressure regulators between the gas canister and pump.

  • Integrate with computer controlling.

  • Obtain a more sensitive regulator to improve accuracy.

  • Construct stand to hold apparatus.

  • Add second pump for gadolinium.

  • Construct an adapter to change IV tubing.


References l.jpg
References pump that wastes a smaller amount of gadolinium and infuses with controllable precision. A prototype has been constructed that uses Bernoulli’s principle of ideal fluid flow. This prototype will be able to deliver a bolus injection, immediately followed by the infusion, while also having the ability to change the flow rates of gadolinium and saline throughout the infusion. This will save both time during the procedure, and money expended on gadolinium. The design is still in the beginning stages, and there are a few modifications and additions to be made to have a device that can be used accurately in an MRI environment.

McMaster-Carr. (2003). Retrieved Nov. 3, 2003, from http://www.mcmaster.com

Medrad. (2003). Spectris Solaris MR injection system.

Retrieved Dec. 4, 2003, from http://www.medrad.com/systems-and-products/magnetic-resonance/spectris-solaris.html

Newman, George C. Personal Interview. Sept. 12, 2003.

Tummescheit, H. (2002). Modeling pitfalls: Some examples in modelica. Retrieved Oct. 17, 2003, from http://www.control.lth.se/~hubertus/pitfalls.pdf


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