The following slides illustrate the substantial research contributions of dr berk
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The following slides illustrate the substantial research contributions of Dr. Berk. . The first slide shows what we knew about one family of kinases, known as mitogen activated protein kinases, in the 1980s. 

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The following slides illustrate the substantial research contributions of dr berk
The following slides illustrate the substantial research contributions of Dr. Berk. 

  • The first slide shows what we knew about one family of kinases, known as mitogen activated protein kinases, in the 1980s. 

  • The second slide shows how much we have learned based in great part on the work of Dr. Berk. As a result of his research, scientists are now able to identify potential targets for therapeutic agents to treat a variety of cardiovascular and non-cardiovascular diseases, such as cancer.


Cell signaling circa 1980
Cell Signaling Circa 1980 contributions of Dr. Berk. 

Surface Receptor

?

Intracellular

Signals

DNA

GROWTH


A MEKK3-MEK5-ERK5 pathway contributions of Dr. Berk. 

Proteins imported

PAR3

MEKK2

P62

MEK5

PAR6

ERK5


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