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Decoding Pedigrees: Unveiling Genetic Inheritance Patterns

Explore pedigrees of diseases like Huntington's, PKU, and hemophilia. Analyze plant and cattle pedigrees to understand trait inheritance in grain plants and GM cattle. Learn how geneticists use pedigrees for breeding desirable traits.

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Decoding Pedigrees: Unveiling Genetic Inheritance Patterns

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  1. Activity 8 Interpreting Pedigrees

  2. Read the introduction. • A pedigree shows generations and relationships among biological parents and offspring. It also tracks which of those individuals have a specific trait.

  3. Challenge • What information can geneticists obtain by analyzing a pedigree?

  4. Analyzing Pedigrees

  5. Pedigree A: Huntington’s Disease

  6. Pedigree B: PKU

  7. Pedigree C: Hemophilia

  8. Analysis 2 • Examine the pedigree below for grain plants with a trait for a high amount of protein. What can you determine about the trait based on the pedigree?

  9. Analysis 3 • How do farmers and agricultural geneticists use the information provided by a pedigree to breed desirable traits in an agricultural crop?

  10. Analysis 4 • On the next slide is a pedigree for cattle that have been genetically modified to produce a human protein that helps prevent blood clots in humans. Using the information in the pedigree, answer the following questions: • What type of inheritance mechanism—dominant, recessive, or sex-lined recessive—is shown in the pedigree? Support your answer with evidence. • From the information in the pedigree from generation 3, can you determine if the gene is still present in the cow population? Explain why or why not?

  11. Analysis 4, continued

  12. Revisit the Challenge • What information can geneticists obtain by analyzing a pedigree?

  13. Key Vocabulary • allele • carrier • Dominant • pedigree • recessive • sex-linked • sex-linked recessive

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