Toxicology of pestic i des
Download
1 / 18

TOXICOLOGY OF PESTIC I DES - PowerPoint PPT Presentation


  • 98 Views
  • Uploaded on

TOXICOLOGY OF PESTIC I DES. Pesticides are preparations for the eradication of plant and animal pests, for the protection of plants, animals and man. About 800 compounds of active ingredients of pesticides have been registered world-wide. Historical background:.

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about ' TOXICOLOGY OF PESTIC I DES' - lerato


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
Toxicology of pestic i des

TOXICOLOGY OF PESTICIDES

Pesticides are preparations for the eradication of plant and animal pests, for the protection of plants, animals and man.

About 800 compounds of active ingredients of pesticides have been registered world-wide.


Historical background
Historical background:

  • alkaloids nicotine and anabasine contained in tobacco – insecticides

  • pyrethrines contained in plants of the genus Pyrethrum – insecticides

    Pyrethrines later became the prototype for synthetic pyrethroids

  • rotenon – is highly toxic to all forms of life, is from roots of lianas. Rotenon was used as a piscicide and insecticide

  • an important milestone was introduction of phenyl mercury in 1913 for the protection of seed – fungicide

  • insecticidal effect of DDT was discovered in 1939 by the Swiss Paul Müller


Classification of pesticides
Classification of pesticides

  • fungicides

  • zoocides (insecticides, rodenticides, molluscocides)

  • herbicides – including desiccants

    • selective

    • non-selective

  • plant growth regulators (to shorten the straw of cereals)

    Desiccation – drying

    desiccant – drying agent

    Desiccants are used for alfalfa (lucern) or clover for seed:plants dry up and can be harvested.


Pesticide degradation

in abiotic environment

the most important factors are light, temperature, photolysis, free radicals produced in photochemical reactions, hydrolysis

in biotic environment

1. phase2. phase

XH X – OH X – O – conjugate

The final products are inactive and are

excreted.

Pesticide degradation


Pesticide transformation
Pesticide transformation

  • mostly detoxicative nature

  • result may even be a more toxic substances (desulphuration of organophosphates)

    parathion paraoxon – a powerful ACHE inhibitor

    trichlorfon dichlorvos

    diazinon diazooxon

    DDT DDE (extremely persistent and

    xenoestrogenic)


Pesticides
Pesticides:

  • Organochlorine pesticides

  • Organophosphates

  • Carbamate pesticides

  • Pyrethroids

  • Phenoxyacetic acid – based pesticides

  • Urea – based pesticides

  • Diazine and triazine pesticides

  • Bipyridil – based pesticides

  • Phenylpyrazoles

  • Metal – based pesticides


Organophosphates insecticides antiparasitics
Organophosphates- insecticides- antiparasitics

Mechanism of toxic action – irreversible

inhibition of enzymes, particularly of

acetylcholinesterase on nerve synapses (by

phosphorylation of hydroxyl group of serine

bound in the active centre of ACHE).


Carbamate pesticides insecticides herbicides fungicides
Carbamate pesticides- insecticides- herbicides- fungicides

Mechanism of the toxic action – reversible inhibition of acetylcholinesterase (by carboxylation of hydroxyl group of serine bound in the active centre of ACHE).

Carbofuran is very up-to-date substance in toxicology. It is used to control vermin (foxes) and is used in baits. Birds are 10times more sensitive to carbofuran than mammals (LD50 for mammals 3 – 19 mg/kg body weight). Frequent carbofuran poisoning cases among predatory birds.


Pyrethroids insecticides antiparasitics
Pyrethroids- insecticides- antiparasitics

Mechanism of the toxic action -

  • pyrethroids T (tremor) – contain no α-cyano group

    cause reversible block of sodium channels (e.g. permethrin)

  • pyrethroids CS (choreoatetosis, salivation) – contain α-cyano group

    cause reversible block of sodium channels and inhibition of GABA (e.g. deltamethrin)


Pyrethroids are- highly toxic for fish (LC50 below 0,1 mg/l)- toxic for bees (LD50 2 – 11 µg/bee)- not very toxic for mammalsCats are most sensitive mammals to pyrethroids.Why? - Pyrethroids’ detoxification, similarly to other organic toxicants, takes place in two phases. Activity of conjugation enzyme, especially of glucuronyl transferase, is very low in cats.


Phenoxyacetic acid based pesticides mcpa herbicides
Phenoxyacetic acid – based pesticides (MCPA)- herbicides

Mechanism of the toxic action –

disruption of oxidation and phosphorylation processes (drop in the ATP production and disruption of energy metabolism).

They are little toxic for mammals, fish, bees.

Symptoms of poisoning: hypotermia, hypodynamia,

paresis, paralysis, tympania in ruminants.

But: In the production and use of those herbicides (2,

4-D; 2,4,5-T) dioxin was produced.


Urea based pesticides herbicides

Urea – based pesticides- herbicides

They cause damage of the thyroid gland and diuron may cause methaemoglobinemia.

In mammals linuron reduces haematopoiesis

In dogs triasulfuron causes cystic hyperplasia of the prostate, vacuolisation of liver cells, anaemia and accumulation of pigment in the liver


Diazine and triazine pesticides herbicides
Diazine and triazine pesticides- herbicides

Diazine pesticides are less toxic than triazine ones

Mechanism of the toxic action –

  • triazines are antimetabolites of pirimidine bases - components of nucleic acids and folic acid

  • atrazine damages the liver detoxication functions

  • simazine, prometryne, terbutryne – inhibit haematopoiesis

    Toxicity: toxic for fish

    relatively harmless for bees

    LD50 for mammals exceeds 1000 mg.kg-1 live weight


Serious risk of triazine based pesticides
Serious risk of triazine – based pesticides

  • very low biodegradability (risk for drinking water)

  • triazines are secondary amines (secondary amines + nitrosation agents

    nitrosamines)

  • atrazine has xenoestrogenic effects (causes abnormal development of gonads, turns amphibians into hermaphrodites)


Bipyridil based pesticides herbicides desiccant
Bipyridil – based pesticides- herbicides- desiccant

They are very rapidly deactivated in soil, but leave

residues in plants: diquat for 3 – 5 days, paraquat for 21 days.

Diquat (Reglone)

LD50 for cattle 30 – 50 mg.kg-1 l.w.

for rabbit 280 mg.kg-1 l.w.

Symptoms of poisoning – pulmonary oedema, damage of liver and kidneys, arthritis, periarthritis


Paraquat (Gramoxone)LD50 for man 40 mg.kg-1 l.w. for cattle and pigs 30 – 70 mg.kg-1 l.w. for dogs and cats 25 – 50 mg.kg-1 l.w.Mechanism of toxic action – is mediated by - free oxygen radicals - proteolytic enzymes formed by active neutrophilic leucocytesSymptoms of poisoning – pulmonary oedema, fibrotic pneumonia fetotoxicity,retardation of ossification


Metal based pesticides
Metal – based pesticides

arsenic compounds – insecticides, rodenticides

phenylmercury – fungicide for treatment of seed (1913 – 1993)

tributyltin – fungicide (xenoestrogenic effect)

thalium compounds – rodenticides

Today

Copper compounds – copper sulphate

- copper oxichloride

fungicides, algicides, molluscocides

Toxicity for fish – LC50 1 – 10 mg.l-1 depending on water quality


Phenylpyrazoles insecticides antiparasitics
Phenylpyrazoles - insecticides- antiparasitics

Mechanism of the toxic action – inhibition of GABA

Fipronil is very toxic for bees (LD50 is 5 ng/bee)

It causes secondary toxicity in bees.

Its residua persists for 21 days.

It produces the „knock down“ effect.


ad