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第二章 分子骨架构建 PowerPoint PPT Presentation


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第二章 分子骨架构建. 有机分子的合成,大体上可分为 分子骨架的构建 和 官能团的转换 两个方面。其中,分子骨架的构建具有根本性意义。因为官能团是连接在分子骨架上的,没有骨架,官能团就失去了依托。. 三聚氰胺. 牛胰岛素结构. 牛胰岛素是牛胰脏中胰岛 β- 细胞所分泌的一种调节糖代谢的蛋白质激素,是一种多肽。 牛胰岛素在医学上有抗炎、抗动脉硬化、抗血小板聚集、治疗骨质增生、治疗精神疾病等作用 。.

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第二章 分子骨架构建

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-

1965


C-C

C-C C-C


2.1

2.2

2.3

2.4

2.5


2.1


  • SN2

  • ,-(Michael)


2.1


2.1

2.1.1

2.1.2

2.1.3

2.1.4

2.1.5

2.1.6


SN2

  • SN2C-C

  • -


2.1.1

  • -

    C6H5- RSO- -CO2R -CN -SO2R -COR-NO2


-

(1)-

(2)

(3)

(4)-

LDA


LDA

:LithiumDiisopropylamide

:[(CH3)2CH]2NLi

:107.12

CASNo:4111-54-0

:

(LithiumDiisopropylamide)1.5-2.0M-5C

LDA


(HMPA)

CAS680-31-9C6H18N3OP

251.0241057.2233201.4579


2.1.2


  • SN2

  • RI RBr RCl


.


,50DNADNA

  • ,,,15

  • ,,,

  • ,,,

(CH3)2SO4


C-.O-N-


ON ,-


(1.4D)

CH2N2


2.1.3

CH



  • ,(Perkin)


Br2I2---

RCH(CO2C2H5)2 RCHBr(CO2C2H5) 2



-


  • (1,4-)

  • ,




-- -1,3-


O-C-O-

C-O-

  • C-

O-

C-


CH3I C-96 C-O-50

C-O-

  • O-

  • O-C-


2.1.4

a.

b.

c.

d. O-C-


-C=C-N-


-

1

2


1


2NN-C-N-C-N-NC


C-

C-


C-


TiCl4


LDA


2.1.5

,-(Michael)

-


5%-10%


-

(Robinson)


2.1.6

  • 3--3--2-

  • NO-

  • NaBH4


NaBH4


2.1 --


RX

H2O/H+

--


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