Types of mutations the power of the base
Download
1 / 10

Types of Mutations The power of the BASE!! - PowerPoint PPT Presentation


  • 89 Views
  • Uploaded on

Types of Mutations The power of the BASE!! . A MUTATION is a change in the DNA Chromosomal Mutations – affect MANY genes ex. Down syndrome 2) ***Gene mutations- affect a SINGLE gene – smaller effect . Frameshift Mutations Insertion – a new base is ADDED to a codon

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about ' Types of Mutations The power of the BASE!! ' - lena


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
Types of mutations the power of the base
Types of Mutations The power of the BASE!!


A MUTATION is a change in the DNA

  • Chromosomal Mutations – affect MANY genes ex. Down syndrome

    2) ***Gene mutations- affect a SINGLE gene – smaller effect


  • Frameshift Mutations

    • Insertion – a new base is ADDED to a codon

      INSERT A “G” 

      ex. AUG UAC GGU

      AUG GUAC GGU

      AUG GUA CGG U

      2. Deletion – a base is REMOVED from a codon

      REMOVE THE “U” 

      ex. AUG UAC GGU

      AUG AC GGU

      AUG ACG GU


  • Huntington Disease: Caused by an Insertion Mutation. You die young (40s or 50s) but you don’t normally know you have it until after you have passed it on to your children.


  • Cystic Fibrosis is a disease sometimes caused by a deletion of a single T base. The hallmark symptoms of cystic fibrosis are salty tasting accumulation of thick, sticky mucous, frequent lung infections, coughing, shortness of breath.

  • Inherited (Recessive Trait)


  • ii. Point Mutation (base substitution) one base isEXCHANGEDfor another

1. Missense- a NEW amino acid is coded for

Ex. UUU is Phenylalanine

Ex. UUA is Leucine



Examples of disease caused by silent mutations
Examples of disease caused by SILENT mutations….????

2. Silent – no CHANGE in the amino acid sequence

Ex. CCC is Proline

Ex. CCG is Proline


3. Nonsense- A STOPcodon before gene is done being translated (Stop codons are UAA, UAG, UGA)

Ex. UGG is Tryptophan but UGA is STOP

!


The disease causes muscle weakness. It usually leads to death by the mid 30s because muscles used to breathe also get weaker.

Duchenne’s Muscular dystrophy can be caused by a nonsense mutation. Look how much shorter the protein is.


ad