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From Noah’s Arkive. From Noah’s Arkive. From Getty, 1975 . From Smith,3 rd ed. Galt trephine. A. Woolums, LAMS 5301. From Noah’s Arkive. From Noah’s Arkive. tracheostomy tube. A. Woolums, LAMS 5301. From Noah’s Arkive. From Noah’s Arkive. From Noah’s Arkive. From Noah’s Arkive.

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Presentation Transcript
slide4

From Smith,3rd ed.

Galt trephine

A. Woolums, LAMS 5301

slide7

tracheostomy tube

A. Woolums, LAMS 5301

slide12

M. haemolytica

leukotoxin

LPS

CD18/CD11a (LFA 1)

proteases

elastases

reactive O2

CD 14

tissue necrosis

IL-8

Fibrinous, necrotizing bronchopneumonia

TNF-a, IL-1b

edema,

hemorrhage,

thrombosis

endothelial cell activation

A. Woolums, LAMS 5301

drugs appropriate for m haemolytica
Drugs appropriate for M haemolytica
  • tetracycline
    • LA 200 (3-day), Tetradure (7 day)
  • spectinomycin
  • ceftiofur
    • Naxcel, Excenel, Excede (7 day)
  • tilmicosin
    • Micotil (3 day)
  • florfenicol
    • Nuflor (2 or 4 day)
  • enrofloxacin or danofloxacin
    • Baytril or A180 (2 day)
  • Tulathromycin
    • Draxxin (7-14 days)

A. Woolums, LAMS 5301

some m haemolytica vaccines
Some M. haemolytica vaccines
  • Once PMH®(Bayer)
    • avirulent live
  • One Shot®(Pfizer)
    • bacterin-toxoid (leukoktoxin, capsular, and cell-associated antigens)
  • Pulmo-Guard™ PH-1 (Bio-Ceutic)
    • bacterin-toxoid (leukotoxin and cell associated antigens)
  • Presponse® SQ (Fort Dodge)
    • adjuvanted toxoid (leukotoxin)

A. Woolums, LAMS 5301

some p multocida vaccines
Some P. multocida vaccines
  • Once PMH®(Bayer)
    • avirulent live P. multocida (with M. haemolytica)
  • Pulmo-Guard™ PH-M (Bio-Ceutic)
    • contains cell associated antigens of P. multocida

(with M. haemolytica leukotoxin and cell-associated ags)

  • Presponse® HM (Fort Dodge)
    • P. multocida bacterial “extract”(with M. haemolytica leukotoxin)
  • Bar-4 (Bio-Ceutic)
    • formalin-inactivated P. multocida with adjuvant

(with inactivated BHV-1, PI3, and M. haemolytica)

A. Woolums, LAMS 5301

drugs appropriate for m bovis
Drugs appropriate for M bovis
  • tetracycline
    • oxytetracycline (parenteral)
    • chlortetracycline (in feed; remember extra label restrictions)
  • spectinomycin
  • florfenicol
  • enrofloxacin or danofloxacin (extra-label?)
  • tulathromycin (specifically labelled)
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