Laboratory animal science
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University of Dublin, Trinity College. Laboratory Animal Science. Peter Nowlan. History. Agenda. Advances in Science and in animal experimentation through the ages The law Experimental Design Animal House design.

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Laboratory Animal Science

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University of Dublin, Trinity College

Laboratory Animal Science

Peter Nowlan

History


Agenda

  • Advances in Science and in animal experimentation through the ages

  • The law

  • Experimental Design

  • Animal House design


SI /17 /94 European Communities (Amendment of Cruelty to Animals Act 1876) Regulations 1994

(12) Persons who carry out experiments or take part in them and persons who take care of animals used for experiments, including duties of a supervisory nature, shall have appropriate education and training.

In particular, persons carrying out or supervising the conduct of experiments shall have received instruction in a scientific discipline relevant to the experimental work being undertaken and be capable of handling and taking care of laboratory animals; they shall also have satisfied the Minister that they have attained a level of training sufficient for carrying out their tasks.


Scientific advances

  • 500 BC Alcmaeon of Crotona (optic nerve function)

  • 464 BC Hippocrates

  • ( oesophageal function)

  • 384 Aristotle

  • 120 AD Galen (humors )


Scientific advances

  • 500 BC Alcmaeon of Crotona (optic nerve function)

  • 464 BC Hippocrates

  • ( oesophageal function)

  • 384 Aristotle

  • 120 AD Galen (humors )


Scientific advances

  • 500 BC Alcmaeon of Crotona (optic nerve function)

  • 464 BC Hippocrates

  • ( oesophageal function)

  • 384 Aristotle

  • 120 AD Galen (humors )


Scientific advances

  • 500 BC Alcmaeon of Crotona

  • 350 BC Hippocrates

  • 384 Aristotle

  • 120 AD Galen Humors

Barbary Ape


GALEN’S HUMOURS

Sanguine

Phlegmatic

Melencholic

Choleric


Scientific advances

  • Middle Ages

  • Little scientific advances. Church dominance

Benedict

Augustine


Scientific advances

  • The Black Death pasturella pestis

  • Thomas Aquinas (1225-1274) broke the impasse between faith and science


Scientific advances

  • The Black Death pasturella pestis

  • Thomas Aquinas (1225-1274) broke the impasse between faith and science


Scientific advances

  • Thomas Aquinas (1225-1274) broke the impasse between faith and science

  • Printing press 1450


Scientific advances

  • Rennasance late 14th centurary

  • Printing Gutenburg 1450 AD


Scientific advances which depended on use of animals

  • 1800

  • LISTER (1840) Carbolic Acid

  • SEMMELWEIS (1840) Child Birth Fever

  • PASTEUR (1857) Vaccines

  • KOCH (1900) Disease Tranmission


Scientific advances which depended on use of animals

  • 1800

  • LISTER (1840) Carbolic Acid

  • SEMMELWEIS (1840) Child Birth Fever

  • PASTEUR (1857) Vaccines

  • KOCH (1900) Disease Tranmission


Scientific advances which depended on use of animals

  • 1800

  • LISTER (1840) Carbolic Acid

  • SEMMELWEIS (1840) Child Birth Fever

  • PASTEUR (1857) Vaccines

  • KOCH (1900) Disease Tranmission


Scientific advances which depended on use of animals

  • 1800

  • LISTER (1840) Carbolic Acid

  • SEMMELWEIS (1840) Child Birth Fever

  • PASTEUR (1857) Vaccines

  • KOCH (1900)

  • Disease

  • Tranmission


Scientific advances which depended on use of animals

  • 1890 vonBehring Diptheria Vaccine & Tetnus antitoxin

  • 1920 INSULIN

  • 1944 Heart Surgery

  • Helen Taussig

  • 1955 Polio Vaccines

  • 1961 Thalidomide


Scientific advances which depended on use of animals

  • 1890 vonBehring Diptheria Vaccine & Tetnus antitoxin

  • 1920 INSULIN

  • 1944 Heart Surgery

  • Helen Taussig

  • 1955 Polio Vaccines

  • 1961 Thalidomide


Scientific advances which depended on use of animals

  • 1890 vonBehring Diptheria Vaccine & Tetnus antitoxin

  • 1920 INSULIN

  • 1944 Heart Surgery

  • Helen Taussig 1963

  • 1955 Polio Vaccines

  • 1961 Thalidomide


Scientific advances which depended on use of animals

  • 1890 vonBehring Diptheria Vaccine & Tetnus antitoxin

  • 1920 INSULIN

  • 1944 Heart Surgery

  • Helen Taussig

  • 1955 Polio Vaccines

  • 1961 Thalidomide


Scientific advances which depended on use of animals

  • 1890 vonBehring Diptheria Vaccine & Tetnus antitoxin

  • 1920 INSULIN

  • 1944 Heart Surgery

  • Helen Taussig

  • 1955 Polio Vaccines

  • 1961 Thalidomide


Scientific advances which depended on use of animals

  • 1964 First Monkey to Human Heart Transplant Norman Shumway CA

  • 1967 First Human to Human Heart Transplant Christiaan Bernard

  • 1970’s Cimetidine

  • Cyclosporin

  • Monoclonal antibodies

  • 1990 DNA probes Transgenic animals


Scientific advances which depended on use of animals

  • 1964 First Monkey to Human Heart Transplant Norman Shumway CA

  • 1967 First Human to Human Heart Transplant Christiaan Barnard

  • 1970’s Cimetidine

  • Cyclosporin

  • Monoclonal antibodies

  • 1990 DNA probes

  • Transgenic animals


Scientific advances which depended on use of animals

  • 1970’s Cimetidine

  • Cyclosporin

  • Monoclonal antibodies

  • 1990 DNA probes

  • Transgenic animals


Scientific advances which depended on use of animals

  • Transgenic

  • animals


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