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University of Dublin, Trinity College. Laboratory Animal Science. Peter Nowlan. History. Agenda. Advances in Science and in animal experimentation through the ages The law Experimental Design Animal House design.

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Laboratory animal science

University of Dublin, Trinity College

Laboratory Animal Science

Peter Nowlan

History


Agenda
Agenda

  • Advances in Science and in animal experimentation through the ages

  • The law

  • Experimental Design

  • Animal House design


Si 17 94 european communities amendment of cruelty to animals act 1876 regulations 1994

SI /17 /94 European Communities (Amendment of Cruelty to Animals Act 1876) Regulations 1994

(12) Persons who carry out experiments or take part in them and persons who take care of animals used for experiments, including duties of a supervisory nature, shall have appropriate education and training.

In particular, persons carrying out or supervising the conduct of experiments shall have received instruction in a scientific discipline relevant to the experimental work being undertaken and be capable of handling and taking care of laboratory animals; they shall also have satisfied the Minister that they have attained a level of training sufficient for carrying out their tasks.


Scientific advances
Scientific advances

  • 500 BC Alcmaeon of Crotona (optic nerve function)

  • 464 BC Hippocrates

  • ( oesophageal function)

  • 384 Aristotle

  • 120 AD Galen (humors )


Scientific advances1
Scientific advances

  • 500 BC Alcmaeon of Crotona (optic nerve function)

  • 464 BC Hippocrates

  • ( oesophageal function)

  • 384 Aristotle

  • 120 AD Galen (humors )


Scientific advances2
Scientific advances

  • 500 BC Alcmaeon of Crotona (optic nerve function)

  • 464 BC Hippocrates

  • ( oesophageal function)

  • 384 Aristotle

  • 120 AD Galen (humors )


Scientific advances3
Scientific advances

  • 500 BC Alcmaeon of Crotona

  • 350 BC Hippocrates

  • 384 Aristotle

  • 120 AD Galen Humors

Barbary Ape


Galen s humours
GALEN’S HUMOURS

Sanguine

Phlegmatic

Melencholic

Choleric


Scientific advances4
Scientific advances

  • Middle Ages

  • Little scientific advances. Church dominance

Benedict

Augustine


Scientific advances5
Scientific advances

  • The Black Death pasturella pestis

  • Thomas Aquinas (1225-1274) broke the impasse between faith and science


Scientific advances6
Scientific advances

  • The Black Death pasturella pestis

  • Thomas Aquinas (1225-1274) broke the impasse between faith and science


Scientific advances7
Scientific advances

  • Thomas Aquinas (1225-1274) broke the impasse between faith and science

  • Printing press 1450


Scientific advances8
Scientific advances

  • Rennasance late 14th centurary

  • Printing Gutenburg 1450 AD


Scientific advances which depended on use of animals
Scientific advances which depended on use of animals

  • 1800

  • LISTER (1840) Carbolic Acid

  • SEMMELWEIS (1840) Child Birth Fever

  • PASTEUR (1857) Vaccines

  • KOCH (1900) Disease Tranmission


Scientific advances which depended on use of animals1
Scientific advances which depended on use of animals

  • 1800

  • LISTER (1840) Carbolic Acid

  • SEMMELWEIS (1840) Child Birth Fever

  • PASTEUR (1857) Vaccines

  • KOCH (1900) Disease Tranmission


Scientific advances which depended on use of animals2
Scientific advances which depended on use of animals

  • 1800

  • LISTER (1840) Carbolic Acid

  • SEMMELWEIS (1840) Child Birth Fever

  • PASTEUR (1857) Vaccines

  • KOCH (1900) Disease Tranmission


Scientific advances which depended on use of animals3
Scientific advances which depended on use of animals

  • 1800

  • LISTER (1840) Carbolic Acid

  • SEMMELWEIS (1840) Child Birth Fever

  • PASTEUR (1857) Vaccines

  • KOCH (1900)

  • Disease

  • Tranmission


Scientific advances which depended on use of animals4
Scientific advances which depended on use of animals

  • 1890 vonBehring Diptheria Vaccine & Tetnus antitoxin

  • 1920 INSULIN

  • 1944 Heart Surgery

  • Helen Taussig

  • 1955 Polio Vaccines

  • 1961 Thalidomide


Scientific advances which depended on use of animals5
Scientific advances which depended on use of animals

  • 1890 vonBehring Diptheria Vaccine & Tetnus antitoxin

  • 1920 INSULIN

  • 1944 Heart Surgery

  • Helen Taussig

  • 1955 Polio Vaccines

  • 1961 Thalidomide


Scientific advances which depended on use of animals6
Scientific advances which depended on use of animals

  • 1890 vonBehring Diptheria Vaccine & Tetnus antitoxin

  • 1920 INSULIN

  • 1944 Heart Surgery

  • Helen Taussig 1963

  • 1955 Polio Vaccines

  • 1961 Thalidomide


Scientific advances which depended on use of animals7
Scientific advances which depended on use of animals

  • 1890 vonBehring Diptheria Vaccine & Tetnus antitoxin

  • 1920 INSULIN

  • 1944 Heart Surgery

  • Helen Taussig

  • 1955 Polio Vaccines

  • 1961 Thalidomide


Scientific advances which depended on use of animals8
Scientific advances which depended on use of animals

  • 1890 vonBehring Diptheria Vaccine & Tetnus antitoxin

  • 1920 INSULIN

  • 1944 Heart Surgery

  • Helen Taussig

  • 1955 Polio Vaccines

  • 1961 Thalidomide


Scientific advances which depended on use of animals9
Scientific advances which depended on use of animals

  • 1964 First Monkey to Human Heart Transplant Norman Shumway CA

  • 1967 First Human to Human Heart Transplant Christiaan Bernard

  • 1970’s Cimetidine

  • Cyclosporin

  • Monoclonal antibodies

  • 1990 DNA probes Transgenic animals


Scientific advances which depended on use of animals10
Scientific advances which depended on use of animals

  • 1964 First Monkey to Human Heart Transplant Norman Shumway CA

  • 1967 First Human to Human Heart Transplant Christiaan Barnard

  • 1970’s Cimetidine

  • Cyclosporin

  • Monoclonal antibodies

  • 1990 DNA probes

  • Transgenic animals


Scientific advances which depended on use of animals11
Scientific advances which depended on use of animals

  • 1970’s Cimetidine

  • Cyclosporin

  • Monoclonal antibodies

  • 1990 DNA probes

  • Transgenic animals



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