Magnetically-Guided Nanoparticle Drug Delivery Seth Baker, RET Fellow 2011 Percy Julian Middle School RET Mentor: Prof. Andreas A. Linninger Chicago Science Teacher Research (CSTR) Program – NSF-RET 2011. Introduction. Magnetite Nanoparticles. Superparamagnetic Properties. Motivation
Magnetically-Guided Nanoparticle Drug DeliverySeth Baker, RET Fellow 2011Percy Julian Middle SchoolRET Mentor: Prof. Andreas A. LinningerChicago Science Teacher Research (CSTR) Program – NSF-RET 2011
Iron ions metabolize and are biodegradable in vivo
Spin glass arrangement
Dipole alignment in the presence of a magnet
Nanoparticles can be coated with various agents
Convection Enhanced Delivery
Capillary experiment set up with 1.0 ml syringe and 30 nm magnetite
173 pound pull force magnet under capillary infused agarose gel
35 and 173 pound pull force magnets affect on capillary experiment
0.26 mm diameter step catheter tip
Rat Brain Tests
Coronal slices of rat brain showing distribution profile of Prussia blue dye.
30 nm magnetite particles delivered on rat brain tissue to determine susceptibility to nanoparticles.
Coronal slices of rat brain after placed in Prussian blue dye to determine untreated brain susceptibility to staining.
Testing Magnetic Susceptibility
Magnetic force was below the injection site and syringe needles were place ¼ inch above magnet in each trial. Red line indicates syringe placement.
There is a general attraction of magnetic nanoparticles through the agarose toward the magnets.
Control for capillary infusion
35 lb pull force magnet trial
30 nanometer Magnetite particles above a 173 pound pull force magnet at 4 minutes
30 nanometer Magnetite particles above a 173 pound pull force magnet at 8 minutes
30 nanometer Magnetite particles above a 173 pound pull force magnet at 0 minutes
173 lb pull force magnet trial
Improved infusion of magnetic nanoparticles
Studying various techniques to reduce the agglomeration of magnetic nanoparticles through the use of various surfactants as well as various catheter design, tube diameters, and nanoparticle concentrations.
Rat brain infusion
Improve methods of introducing magnetic nano-particles into fresh brain tissue.