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Memantine in Severe Dementia: Results of the M-Best Study Benefit and Efficacy in Severely Demented Patients During Treatment With Memantine. B. Winblad and N. Poritis International Journal of Geriatric Psychiatry 1999, 14: 135-146 . Study Design. No. of patients N = 166 (nursing home)

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B winblad and n poritis international journal of geriatric psychiatry 1999 14 135 146 l.jpg

Memantine in Severe Dementia: Results of the M-Best StudyBenefit and Efficacy in Severely Demented Patients During Treatment With Memantine

B. Winblad and N. Poritis

International Journal of Geriatric Psychiatry 1999, 14: 135-146


Study design l.jpg
Study Design

No. of patients N = 166 (nursing home)

Design Double-blind, randomized, placebo- controlled, multicenter study

Diagnosis Primary dementia (AD, VaD, mixed types)

Age 60 – 80 years (mean 68.4)

Severity MMSE < 10 (mean 6.3), GDS 5 – 7

Dose; duration 10 mg memantine/day; 12 weeks

Primary efficacy Global: CGI-C parameters Care Dependence: BGP subscore

Secondary efficacy Function/Behavior: D-Scale, BGPparameter

Winblad and Poritis., Int J Geriat Psychiatr 1999


Memantine improves global impression cgi c l.jpg

80

70

60

50

40

30

20

10

0

**

73%

*

59%

45%

40%

Memantine

Placebo

Memantine

Placebo

Week 4

Week 12

Memantine Improves Global Impression (CGI-C)

ITT analysis, N = 166 Response = improvement

Responders [%] in CGI-C

*p = 0.006, ** p = 0.001 versus placebo

Winblad and Poritis., Int J Geriat Psychiatr 1999


Summary l.jpg
Summary

  • Memantine is efficacious in severely demented patients suffering from probable Alzheimer’s disease or probable vascular dementia

  • Functional improvement was significant in memantine- treated patients

  • Tolerability of memantine was good

Winblad and Poritis., Int J Geriat Psychiatr 1999


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