Pharmacology for Anesthesia I. Introduction. What is a Drug?. Pharmacokinetics (PK). What the body does to the drug Absorption Distribution Metabolism Excretion. Absorption. The process of diffusion or transport of a drug from the site of administration to the plasma.
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What the body does to the drug
The process of diffusion or transport of a drug from the site of administration to the plasma
Skipped by administering drugs parenterally
Inhaled agents require special considerations
concentration gradient x surface area x diffusion coefficient
Rate of Diffusion =
Diffusion coefficient =
Henderson – Hasselbalch Equation
= pKa - pH
The process of diffusion of a drug throughout the body
Generally governed by the same characteristics as absorption
Vd = volume of distribution
Example of Zero order kinetics
Partial agonists receptor?
Potency vs. Efficacy