pharmacology for anesthesia i
Download
Skip this Video
Download Presentation
Pharmacology for Anesthesia I

Loading in 2 Seconds...

play fullscreen
1 / 40

Pharmacology for Anesthesia I - PowerPoint PPT Presentation


  • 113 Views
  • Uploaded on

Pharmacology for Anesthesia I. Introduction. What is a Drug?. Pharmacokinetics (PK). What the body does to the drug Absorption Distribution Metabolism Excretion. Absorption. The process of diffusion or transport of a drug from the site of administration to the plasma.

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about ' Pharmacology for Anesthesia I' - leandra-knapp


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
pharmacokinetics pk
Pharmacokinetics (PK)

What the body does to the drug

  • Absorption
  • Distribution
  • Metabolism
  • Excretion
slide5

Absorption

The process of diffusion or transport of a drug from the site of administration to the plasma

Skipped by administering drugs parenterally

Inhaled agents require special considerations

fick s law
Fick’s Law

concentration gradient x surface area x diffusion coefficient

membrane thickness

Rate of Diffusion =

Permeability

Size

Diffusion coefficient =

slide7

Ionization State

Henderson – Hasselbalch Equation

concentration (protonated)

concentration (unprotonated)

log

= pKa - pH

distribution
Distribution

The process of diffusion of a drug throughout the body

Generally governed by the same characteristics as absorption

Vd = volume of distribution

Protein Binding

metabolism
Metabolism
  • The enzymatic modification of the drug molecule by the body
    • Often occurs in liver
    • May occur elsewhere
elimination
Elimination
  • The removal of the drug from the body
    • Renal
    • Hepatic
    • Respiratory
    • Cutaneous
clearance
Clearance
  • Used to describe our ability to eliminate the active ingredient
    • Combination of metabolism and excretion

Example of Zero order kinetics

slide23

Distribution and Clearance

  • First Order Kinetics
    • Single compartment model
    • Double compartment model
    • Three compartment model
    • Etc.
pharmacodynamics
Pharmacodynamics
  • What the drug does to the body
    • Typically receptor mediated
slide31

What factors affect the ability of a drug to interact with a receptor?

  • Drug size
    • Large enough to be specific
    • Not so large as to be unable to interact with the receptor
  • Drug Shape
slide32

Some drugs do not appear to fit into these categories

    • Osmotic agents
    • Transport regulators
slide33

Agonists

Antagonists

Competitive

Noncompetitive

Allosteric Activators

Potentiators

slide34

Partial agonists

Inverse agonists

ad