Leiomyosarcoma – Undifferentited Pleomorphic Sarcoma. Dr Philippe CASSIER, MD Centre Léon Bérard Lyon, France. Outline. Local therapy Prognosis Molecular markers Therapeutic intervension. Local therapy - Surgery.
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Leiomyosarcoma– UndifferentitedPleomorphic Sarcoma.
Dr Philippe CASSIER, MD
Centre Léon Bérard
how good a margin do we need?
how can we further improve local control
Metastasis-Free Survival, Negative vs. Positive Critical Structure Margin
Negative Critical Structure Margin 72.7% (p = 0.005)
Positive Critical Structure Margin 52.2%
Chi-square/ Fisher’s Exact for depth/grade
t-test for size as it is continuous
Divi et al.
N=640 yrs 1982-present
Lusby et al.
N=349 yrs 1989-2011
Kosela et al.
N=162 yrs 1998-2010
Hierarchicalclustering identifies differentssubtypes
Nielsen TO et al. Lancet 2002
15 samples of UPS
Apply to 114 STS samples
Wu et al. Cancer Res 2007
PrMet – Skubitz et al Cancer 2012
Skubitz et al. CTOS
CINSARC – Chibon et al. Nat Med 2010
Median PFS = 9.1 weeks (90% CI, 6.1-12.4)
George et al. CTOS 2012
Median 2.9 months
O’Cearbhaill et al. GynecolOncol 2010
Systemic chemotherapy for inoperable, locally advanced, recurrent or metastatic uterine leiomyosarcoma: a systematic review. A. Gupta et al