Inverse grid2 6 central lymphoid organ
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Inverse Grid2-6 中枢免疫器官 ( Central lymphoid organ ) PowerPoint PPT Presentation


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Inverse Grid2-6 中枢免疫器官 ( Central lymphoid organ ). 骨髓和法氏囊( Bone Marrow and bursa of Fabricius ). A bilobbed primary lymphoid organ that is required for the generation of immunocompetent CD3CD4 and CD3CD8 cells necessary for adaptive immune response. 胸腺( Thymus ).

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Inverse Grid2-6 中枢免疫器官 ( Central lymphoid organ )

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Inverse grid2 6 central lymphoid organ

Inverse Grid2-6 Central lymphoid organ

Bone Marrow and bursa of Fabricius

A bilobbed primary lymphoid organ that is required for the generation of immunocompetent CD3CD4 and CD3CD8 cells necessary for adaptive immune response.

Thymus


Inverse grid2 6 central lymphoid organ

2-6Central lymphoid organ

Bone Marrow and bursa of Fabricius

Thymus

A bilobbed primary lymphoid organ that is required for the generation of immunocompetent CD3CD4 and CD3CD8 cells necessary for adaptive immune response.


Inverse grid2 6 central lymphoid organ

Bursa of Fabricius

Bruce Glick and Charlie Chang


Inverse grid2 6 central lymphoid organ

  • Thymus

  • -

  • 30-40


Inverse grid2 6 central lymphoid organ


Inverse grid2 6 central lymphoid organ

Thymic Tissue Architecture

The thymus is made up of various cell type derived from different origin. Histologically, the thymus has three distinct components: subcapsular cortex, cortex and medulla. Development of T cells or thymucytes are found embedded in an epithelial network known as thymic stroma. The thymic anlage provides an inductive environment that allows precursor T cells to rapidly expand and differentiate.


Inverse grid2 6 central lymphoid organ

2-7Peripheral lymphoid organ

  • lymphnodes

  • spleen

  • mucosa-associated lymphoid system

  • tonsil


Inverse grid2 6 central lymphoid organ

  • High endothelial venuleHEV

HEV are specialized venules found in lymphoid tissues. Lymphocytes migrate from blood into lymphoid tissues by attaching to and migrating across the high endothelial cells of the vessels.


Inverse grid2 6 central lymphoid organ

  • germinal center

Germinal centers in secondary lymphoid tissues are sites of intense B cell proliferation, selection, and death during Ab responses. Germinal centers form around follicular dendritic cell network when activated B cells migrate into lymphoid follicles.

primary follicle

secondary follicle= germinal center


Inverse grid2 6 central lymphoid organ

Lymph nodes are encapsulated strictures that are strategically placed throughout the body to receive and filter antigens and cells from peripheral interstitial fluid and lymph. All lymph nodes eventually drain into the thoracic duct and back to the peripheral blood.


Inverse grid2 6 central lymphoid organ

HEV


Inverse grid2 6 central lymphoid organ


Inverse grid2 6 central lymphoid organ


Inverse grid2 6 central lymphoid organ

  • Spleen

  • white pulp

  • 1periarterial lymphatic sheathPALST

  • 2BPALS

  • red pulp

  • 2/3

  • 1

  • 2


Inverse grid2 6 central lymphoid organ

M

B

T


Inverse grid2 6 central lymphoid organ

sIgA

M

IgA

Th

B


Inverse grid2 6 central lymphoid organ

2-7 Recirculation of lymphocytes ()

Both T and B cells continuously circulate and recirculate, blood to lymph to blood. Approximately 1-2% recirculate every hour. NK cells are only found in blood, spleen and liver.


Inverse grid2 6 central lymphoid organ

12

5

52%

45%

42%

30

10%

10%


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