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Cream Formulation. Kausar Ahmad Kulliyyah of Pharmacy. http://staff.iium.edu.my/akausar. Contents. Examples of Creams. Formulation. Ideal formulation. Formulation requirement: efficacy, safety, and quality. Factors to be considered in formulation. Choice of vehicle.

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Cream formulation

Cream Formulation

Kausar Ahmad

Kulliyyah of Pharmacy

http://staff.iium.edu.my/akausar

PHM4153 Dosage Design 2 2011/12


Contents
Contents

PHM4153 Dosage Design 2 2011/12


Examples of creams
Examples of Creams

PHM4153 Dosage Design 2 2011/12


Formulation
Formulation

PHM4153 Dosage Design 2 2011/12


Ideal formulation
Ideal formulation

PHM4153 Dosage Design 2 2011/12


Formulation requirement efficacy safety and quality
Formulation requirement: efficacy, safety, and quality

PHM4153 Dosage Design 2 2011/12


Factors to be considered in formulation
Factors to be considered in formulation

PHM4153 Dosage Design 2 2011/12


Choice of vehicle
Choice of vehicle

PHM4153 Dosage Design 2 2011/12


Examples of oils fats
Examples of Oils & Fats

PHM4153 Dosage Design 2 2011/12


Advantages of silicones
Advantages of Silicones

PHM4153 Dosage Design 2 2011/12


Examples of lipids
Examples of Lipids

PHM4153 Dosage Design 2 2011/12


Choosing oils
Choosing Oils

Properties

Limitation

PHM4153 Dosage Design 2 2011/12

Emollient effect

Shine

Lubricity

Spreadability

Solvency

Drying

Odour

Colour

Viscosity

Miscibility with other oils

Toxicity

Impurities

Cost


Polarity of oils
Polarity of oils

Non-polar

Polar

PHM4153 Dosage Design 2 2011/12

Lasting emollient effect

Barrier effect

Inert

Stable against oxidation

Shine

Spreadability

cheap

Varying emollient effect

Little barrier effect

Varying stability against oxidation

Good absorption

Good delivery

expensive


Excipients
Excipients

PHM4153 Dosage Design 2 2011/12


Categories of excipients
Categories of excipients

PHM4153 Dosage Design 2 2011/12


Choosing excipients
Choosing excipients

PHM4153 Dosage Design 2 2011/12


Emulsifiers
Emulsifiers

PHM4153 Dosage Design 2 2011/12


Penetration enhancers
Penetration enhancers

  • Increase delivery of active substance by:

PHM4153 Dosage Design 2 2011/12


Hydration
Hydration

Q. How does urea moisturise the skin?

PHM4153 Dosage Design 2 2011/12




Ph adjustment
pH adjustment

PHM4153 Dosage Design 2 2011/12


Preservatives
Preservatives

PHM4153 Dosage Design 2 2011/12


Anti oxidant
Anti-oxidant

PHM4153 Dosage Design 2 2011/12


Uv filters
UV filters

PHM4153 Dosage Design 2 2011/12


Other types of excipients
Other types of excipients

PHM4153 Dosage Design 2 2011/12


Effects of e xcipients
Effects of excipients

PHM4153 Dosage Design 2 2011/12


Physicochemical properties
Physicochemical properties

PHM4153 Dosage Design 2 2011/12


Physical and chemical properties of excipients
Physical and chemical properties of excipients

PHM4153 Dosage Design 2 2011/12


Polyamide: Carrier for insoluble ingredients; Protector for sensitive ingredients; Slow delivery & long lasting effect

7 m, empty spheres

10 m, porous

PHM4153 Dosage Design 2 2011/12


Excipient particle size distribution
Excipient: Particle size distribution

PHM4153 Dosage Design 2 2011/12


Excipient pore volume pore diameter
Excipient: Pore volume & pore diameter

PHM4153 Dosage Design 2 2011/12


Incompatibility
Incompatibility

PHM4153 Dosage Design 2 2011/12


Detection of incompatibility
Detection of Incompatibility

PHM4153 Dosage Design 2 2011/12


Effect of type of preparation absorption of retinyl palmitate
Effect of type of preparation: Absorption of retinylpalmitate

Exercise:

18% absorbed from acetone vehicle

compared to only

4% absorbed from o/w emulsion

  • WHY?

PHM4153 Dosage Design 2 2011/12


Exercise determine functions of excipients
Exercise: Determine functions of excipients

Nizoral cream

Ketoconazole

PPG

Stearyl alcohol

Cetyl alcohol

Sorbitanstearate

Polysorbate

Isopropyl myristate

Sodium sulfite

Purified water

Elomet cream 0.1%

Mometasonefuroate

White petrolatum

White wax

PPG stearate

Stearyl alcohol

Ceteareth-20

Hexylene glycol

Titanium dioxide

Al starch octenylsuccinate

Purified water

Phosphoric acid

PHM4153 Dosage Design 2 2011/12


References
References

Bugay, D. E. (1999). Pharmaceutical excipients : characterization by IR, Raman, and NMR spectroscopy.RS201E87B931P

Kibbe, A. H. (2000). Handbook of pharmaceutical excipients.RS201E87H236K

Rowe, R. C., Sheskey, P. J. & Owen, S. C. (2006). Handbook of pharmaceutical excipientsRS201E87H236K

Rowe, R. C. (2009). Handbook of pharmaceutical excipients. RS201E87H236K

PHM4153 Dosage Design 2 2011/12


Some materials sourced from the following:

http://www.eastman.com/Markets/Pharmaceutical/Excipients/Excipients_intro.asp

http://www.pharmaceutical-technology.com/contractors/materials/uniqema/

http://www.pformulate.com/

http://images.vertmarkets.com/CRLive/files/Downloads/89FB7970-7376-44A0-B6B6-4B171E4B978B/InsolubleKollidon.pdf

Thank you to contributors.

PHM4153 Dosage Design 2 2011/12


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