Cream formulation
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Cream Formulation. Kausar Ahmad Kulliyyah of Pharmacy. http://staff.iium.edu.my/akausar. Contents. Examples of Creams. Formulation. Ideal formulation. Formulation requirement: efficacy, safety, and quality. Factors to be considered in formulation. Choice of vehicle.

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Cream Formulation

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Cream formulation

Cream Formulation

Kausar Ahmad

Kulliyyah of Pharmacy

http://staff.iium.edu.my/akausar

PHM4153 Dosage Design 2 2011/12


Contents

Contents

PHM4153 Dosage Design 2 2011/12


Examples of creams

Examples of Creams

PHM4153 Dosage Design 2 2011/12


Formulation

Formulation

PHM4153 Dosage Design 2 2011/12


Ideal formulation

Ideal formulation

PHM4153 Dosage Design 2 2011/12


Formulation requirement efficacy safety and quality

Formulation requirement: efficacy, safety, and quality

PHM4153 Dosage Design 2 2011/12


Factors to be considered in formulation

Factors to be considered in formulation

PHM4153 Dosage Design 2 2011/12


Choice of vehicle

Choice of vehicle

PHM4153 Dosage Design 2 2011/12


Examples of oils fats

Examples of Oils & Fats

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Advantages of silicones

Advantages of Silicones

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Examples of lipids

Examples of Lipids

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Choosing oils

Choosing Oils

Properties

Limitation

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Emollient effect

Shine

Lubricity

Spreadability

Solvency

Drying

Odour

Colour

Viscosity

Miscibility with other oils

Toxicity

Impurities

Cost


Polarity of oils

Polarity of oils

Non-polar

Polar

PHM4153 Dosage Design 2 2011/12

Lasting emollient effect

Barrier effect

Inert

Stable against oxidation

Shine

Spreadability

cheap

Varying emollient effect

Little barrier effect

Varying stability against oxidation

Good absorption

Good delivery

expensive


Excipients

Excipients

PHM4153 Dosage Design 2 2011/12


Categories of excipients

Categories of excipients

PHM4153 Dosage Design 2 2011/12


Choosing excipients

Choosing excipients

PHM4153 Dosage Design 2 2011/12


Emulsifiers

Emulsifiers

PHM4153 Dosage Design 2 2011/12


Penetration enhancers

Penetration enhancers

  • Increase delivery of active substance by:

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Hydration

Hydration

Q. How does urea moisturise the skin?

PHM4153 Dosage Design 2 2011/12


Cream formulation

PHM4153 Dosage Design 2 2011/12


Cream formulation

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Ph adjustment

pH adjustment

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Preservatives

Preservatives

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Anti oxidant

Anti-oxidant

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Uv filters

UV filters

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Other types of excipients

Other types of excipients

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Effects of e xcipients

Effects of excipients

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Physicochemical properties

Physicochemical properties

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Physical and chemical properties of excipients

Physical and chemical properties of excipients

PHM4153 Dosage Design 2 2011/12


Cream formulation

Polyamide: Carrier for insoluble ingredients; Protector for sensitive ingredients; Slow delivery & long lasting effect

7 m, empty spheres

10 m, porous

PHM4153 Dosage Design 2 2011/12


Excipient particle size distribution

Excipient: Particle size distribution

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Excipient pore volume pore diameter

Excipient: Pore volume & pore diameter

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Incompatibility

Incompatibility

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Detection of incompatibility

Detection of Incompatibility

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Effect of type of preparation absorption of retinyl palmitate

Effect of type of preparation: Absorption of retinylpalmitate

Exercise:

18% absorbed from acetone vehicle

compared to only

4% absorbed from o/w emulsion

  • WHY?

PHM4153 Dosage Design 2 2011/12


Exercise determine functions of excipients

Exercise: Determine functions of excipients

Nizoral cream

Ketoconazole

PPG

Stearyl alcohol

Cetyl alcohol

Sorbitanstearate

Polysorbate

Isopropyl myristate

Sodium sulfite

Purified water

Elomet cream 0.1%

Mometasonefuroate

White petrolatum

White wax

PPG stearate

Stearyl alcohol

Ceteareth-20

Hexylene glycol

Titanium dioxide

Al starch octenylsuccinate

Purified water

Phosphoric acid

PHM4153 Dosage Design 2 2011/12


References

References

Bugay, D. E. (1999). Pharmaceutical excipients : characterization by IR, Raman, and NMR spectroscopy.RS201E87B931P

Kibbe, A. H. (2000). Handbook of pharmaceutical excipients.RS201E87H236K

Rowe, R. C., Sheskey, P. J. & Owen, S. C. (2006). Handbook of pharmaceutical excipientsRS201E87H236K

Rowe, R. C. (2009). Handbook of pharmaceutical excipients. RS201E87H236K

PHM4153 Dosage Design 2 2011/12


Cream formulation

Some materials sourced from the following:

http://www.eastman.com/Markets/Pharmaceutical/Excipients/Excipients_intro.asp

http://www.pharmaceutical-technology.com/contractors/materials/uniqema/

http://www.pformulate.com/

http://images.vertmarkets.com/CRLive/files/Downloads/89FB7970-7376-44A0-B6B6-4B171E4B978B/InsolubleKollidon.pdf

Thank you to contributors.

PHM4153 Dosage Design 2 2011/12


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