Dry Cow Therapy, Mastitis and            Milk - Enhancement
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Dry Cow Therapy, Mastitis and Milk - Enhancement. Nissim Silanikove , Agricultural Research Organization, Institute of Animal Science, Israel. http://publicationslist.org/silanikove. Gabriel Leitner , The Veterinary Institute, Israel. Conventional. Organic. U. K. 37.1. 34.7.

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Dry Cow Therapy, Mastitis and Milk - Enhancement

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Dry cow therapy mastitis and milk enhancement

Dry Cow Therapy, Mastitis and Milk - Enhancement

Nissim Silanikove, Agricultural Research Organization, Institute of Animal Science, Israel.

http://publicationslist.org/silanikove

Gabriel Leitner, The Veterinary Institute, Israel


Mastitis

Conventional

Organic

U. K.

37.1

34.7

Mastitis

Mastitis affects one third of all dairy cows annually ¹

¹ National Mastitis Council, Current Concepts in Bovine Mastitis, Madison, WI, 1996.


Mastitis costs

Mastitis Costs

$

Mastitis costs the U.S. dairy industry over $2 Billion annually (W L Hurley, Department of Animal Sciences, University of Illinois, 2001.)

The worldwide estimated cost of mastitis to the dairy industry is $10.34 Billion annually.


Current drug treatment

Current Drug Treatment

Milk Enhancement - Posilac .

Dry Cow Treatment - Antibiotics . Mastitis - Antibiotics .


Milk withdrawal antibiotics

Milk Withdrawal - Antibiotics


Total milk losses per cow treated

Total Milk Losses Per Cow Treated


Milk loss and cost of discard milk

Milk Loss and Cost of Discard Milk


Dry cow therapy mastitis and milk enhancement

Secretion of large number of activated neutrophils.

Enhanced secretion of immunoglobulins.

Formation of bactericide environment:

Secretion of antimicrobial proteins and free radicals formation.

Drastic reduction in lactose and citrate concentration: elimination of food for bacteria.

The Physiological Basis

Dramatic activation of the innate immune system within 8 hours


Dry cow therapy mastitis and milk enhancement

Evacuate the treated gland and infuse the drug into the cistern.

Repeat the treatment twice over two days.

Don’t milk between treatments.

After the last treatment the gland is not milked until the next lactation.

Treatment procedures


Dry cow therapy mastitis and milk enhancement

Treated Gland

Control Gland

Histology of gland treated with casein hydrolyzate (CNH) vs. non-treated gland


Dry cow therapy mastitis and milk enhancement

CNH in Goats: Precipitous drying of milk secretion only in the treated gland

Silanikove et al, Life Sci., 2002


Dry cow therapy mastitis and milk enhancement

SCC - POST

SCC - PRE

Average

Average

Staphylococcus aureus

5

1,235.2

147.4

All Streptococcus

1

7

3,357.4

262.3

Escherichia coli

7

1,781.2

275.4

Arcanobacterium pyogenes

10

1,465.1

145.6

Others

6

3,283.5

226.7

All:

Average SCC

2,210.2

205.0

Standard deviation

2,374.3

170.2

SCC (×1000) before treatment and 15 to 60 days after treatment in 45 cows

Somatic Cell Counts

Pathogens

Number

Note: SCC-PRE denotes pre-treatment somatic cell counts; SCC-POST denotes post-treatment somatic cell count. Pooled across herds (n=10) and period, 2001-2003.


Dry cow therapy mastitis and milk enhancement

0

200

201

400

0

8 %

Clinical

22 %

22%

8 %

40 %

Subclinical

62 %

30%

8 %

Total

SCC (×1000) frequencies after treatment with CNH

Stage

>401


Dry cow therapy mastitis and milk enhancement

25.9 %

100

£

33.3 %

101 - 200

201 - 400

25.9 %

³

401

14.8 %

SCC (×1000) frequencies after treatment with CNH in the following lactation

Reminder : pretreatment average SCC was 2,210.2


Dry cow therapy mastitis and milk enhancement

S. aureus

5

1

All Streptococcus

6

2

E. coli

4

1

pyogenesA.

10

0

Others

8

0

Total

33

4

Bacterial cure in cows treated with CNH

Detected microorganism before treatment

Detected microorganism after treatment

Cure rate of 88.87 %

P < .05


Dry cow therapy mastitis and milk enhancement

The risk of new intramammary infections might be reduced if milk production decreased prior to dry off, the udder involuted rapidly, and the teat canal closed in a timely manner".

R.T. Dingwell et al. 2001; National Mastitis Council Annual Meeting Proceedings, pp. 69-79; NMC, Verona, Wisconsin

"For every 5 kg increase in milk yield at dry-off above 12.5 kg, the odds of a cow having an environmental intramammary infection at calving increased at least by 77%".

Rajala-Schultz et al.; J Dairy Sci 2005; 88; 577-9

Dry period and new infections


Dry cow therapy mastitis and milk enhancement

Evacuate the treated gland and infuse the drug into the cistern.

Treat all glands with or without antibiotics

Dry period: Treatment procedures


Dry cow therapy mastitis and milk enhancement

Experimental structure: animals (number and types), treatments, and periods


Dry cow therapy mastitis and milk enhancement

Bacterial status (infected, noninfected, chronic, clinic and cured) in period 2 (following Nafpenzal DC+ CNH at DCT) and period 3 (following Nafpenzal DC)

1Uninfected quarter before drying off and uninfected at parturition.

2 New Infection, chronic – Infection was detected during parturition and in the first 100 days in the new lactation: The same udders were uninfected before drying off.

3 New Infection, clinical – Infection was detected during the first month after parturition and remained for the first 100 days in the new lactation: The same udders were uninfected before drying off.

4Cure – Bacteria detected in the month preceding dry off was not detected in the same udder during the first 100 days of lactation

5 Not Cured – The reciprocal of cured: Bacteria detected in given udders in the month preceding dry off was also detected in the same udder during the first 100 days of the subsequent lactation.


Dry cow therapy mastitis and milk enhancement

Cow 2425


Dry cow therapy mastitis and milk enhancement

Cow 2331


Dry cow therapy mastitis and milk enhancement

Conclusions

CNH improve dramatically milk hygiene immediately, without the need to discard milk from the uninfected gland.

CNH is effective where no alternative treatments exist.

CNH gained high rate of bacterial cure, with secretion of milk with low SCC during the next lactation cycle.

CNH is effective as a dry period treatment: eradicates existing infections, prevents new infectionsand lowers SCC.

CNH increases milk yield similar to growth hormone.

CNH has the potential to shortens the length of the dry period without adversely affecting milk yield in the subsequent lactation.

.


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