Dry Cow Therapy, Mastitis and Milk - Enhancement. Nissim Silanikove , Agricultural Research Organization, Institute of Animal Science, Israel. http://publicationslist.org/silanikove. Gabriel Leitner , The Veterinary Institute, Israel. Conventional. Organic. U. K. 37.1. 34.7.
Nissim Silanikove, Agricultural Research Organization, Institute of Animal Science, Israel.
Gabriel Leitner, The Veterinary Institute, Israel
Mastitis affects one third of all dairy cows annually ¹
¹ National Mastitis Council, Current Concepts in Bovine Mastitis, Madison, WI, 1996.
Mastitis costs the U.S. dairy industry over $2 Billion annually (W L Hurley, Department of Animal Sciences, University of Illinois, 2001.)
The worldwide estimated cost of mastitis to the dairy industry is $10.34 Billion annually.
Milk Enhancement - Posilac .
Dry Cow Treatment - Antibiotics . Mastitis - Antibiotics .
Enhanced secretion of immunoglobulins.
Formation of bactericide environment:
Secretion of antimicrobial proteins and free radicals formation.
Drastic reduction in lactose and citrate concentration: elimination of food for bacteria.
The Physiological Basis
Dramatic activation of the innate immune system within 8 hours
Repeat the treatment twice over two days.
Don’t milk between treatments.
After the last treatment the gland is not milked until the next lactation.
Treated Gland cistern.
Histology of gland treated with casein hydrolyzate (CNH) vs. non-treated gland
CNH in Goats: Precipitous drying of milk secretion only in the treated gland
Silanikove et al, Life Sci., 2002
SCC - POST only in the treated gland
SCC - PRE
SCC (×1000) before treatment and 15 to 60 days after treatment in 45 cows
Somatic Cell Counts
Note: SCC-PRE denotes pre-treatment somatic cell counts; SCC-POST denotes post-treatment somatic cell count. Pooled across herds (n=10) and period, 2001-2003.
0 only in the treated gland
SCC (×1000) frequencies after treatment with CNH
25.9 % only in the treated gland
101 - 200
201 - 400
SCC (×1000) frequencies after treatment with CNH in the following lactation
Reminder : pretreatment average SCC was 2,210.2
S. aureus only in the treated gland
Bacterial cure in cows treated with CNH
Detected microorganism before treatment
Detected microorganism after treatment
Cure rate of 88.87 %
P < .05
The risk of new intramammary infections might be reduced if milk production decreased prior to dry off, the udder involuted rapidly, and the teat canal closed in a timely manner".
R.T. Dingwell et al. 2001; National Mastitis Council Annual Meeting Proceedings, pp. 69-79; NMC, Verona, Wisconsin
"For every 5 kg increase in milk yield at dry-off above 12.5 kg, the odds of a cow having an environmental intramammary infection at calving increased at least by 77%".
Rajala-Schultz et al.; J Dairy Sci 2005; 88; 577-9
Dry period and new infections
Treat all glands with or without antibiotics
Dry period: Treatment procedures
Experimental structure: animals (number and types), treatments, and periods
Bacterial status (infected, noninfected, chronic, clinic and cured) in period 2 (following Nafpenzal DC+ CNH at DCT) and period 3 (following Nafpenzal DC)
1Uninfected quarter before drying off and uninfected at parturition.
2 New Infection, chronic – Infection was detected during parturition and in the first 100 days in the new lactation: The same udders were uninfected before drying off.
3 New Infection, clinical – Infection was detected during the first month after parturition and remained for the first 100 days in the new lactation: The same udders were uninfected before drying off.
4Cure – Bacteria detected in the month preceding dry off was not detected in the same udder during the first 100 days of lactation
5 Not Cured – The reciprocal of cured: Bacteria detected in given udders in the month preceding dry off was also detected in the same udder during the first 100 days of the subsequent lactation.
Cow 2425 cured) in period 2 (following Nafpenzal DC+ CNH at DCT) and period 3 (following Nafpenzal DC)
Cow 2331 cured) in period 2 (following Nafpenzal DC+ CNH at DCT) and period 3 (following Nafpenzal DC)
Conclusions cured) in period 2 (following Nafpenzal DC+ CNH at DCT) and period 3 (following Nafpenzal DC)
CNH improve dramatically milk hygiene immediately, without the need to discard milk from the uninfected gland.
CNH is effective where no alternative treatments exist.
CNH gained high rate of bacterial cure, with secretion of milk with low SCC during the next lactation cycle.
CNH is effective as a dry period treatment: eradicates existing infections, prevents new infectionsand lowers SCC.
CNH increases milk yield similar to growth hormone.
CNH has the potential to shortens the length of the dry period without adversely affecting milk yield in the subsequent lactation.