Introduction and Classification of Anaemia PALI Haematology Session 3 rd October 2012 Christopher Mullen. Overview of Presentation. Introduction Classification The Hypochromic Anaemias Megaloblastic and other macrocytic anaemias Haemolytic anaemias Genetic disorders of haemoglobin
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Introduction and Classification of Anaemia
PALI Haematology Session
3rd October 2012
Overview of Presentation
General Clinical Features
The Hypochromic Anaemias
Iron Deficiency Anaemia
Iron deficiency anaemia is not a diagnosis – an underlying cause must be sought
Anaemia of Chronic Disease
Secondary to liver and renal disease
Chemical Features of Intravascular Haemolysis
Red cells are broken down by macrophages or the reticuloendothelial system
Genetic disorders of haemoglobin – Sickle Cell Anaemia
You are a GP trainee and Mrs J, a 24 year old lady, presents to the clinic. She has just moved to your area, her notes haven’t arrived at the surgery, and she is complaining of tiredness. She doesn’t wish to be fully examined but clinically you suspect anaemia and you arrange a full blood count, results of which are shown below.
She returns to health centre and this time you notice that she is also slightly icteric. Urine analysis shows urobilinogen but no bilirubin. There is no glycosuria, haematuria or pyuria. The serum bilirubin concentration is 65 Kmols/l (normal range 15 – 22 Kmols/litre).