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Neurolathyrism. Haileyesus Getahun South Gonder Health Department, Ethiopia. Neurolathyrism. Synonym lathyrism Neurolathyrism (NL) is a neurodegenerative disease that is caused by heavy consumption of grass pea, Lathyrus sativus. The Toxin.

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neurolathyrism

Neurolathyrism

Haileyesus Getahun

South Gonder Health Department, Ethiopia

neurolathyrism1
Neurolathyrism
  • Synonym lathyrism
  • Neurolathyrism (NL) is a neurodegenerative disease that is caused by heavy consumption of grass pea, Lathyrus sativus.
the toxin
The Toxin

The pulse contains the neurotoxin called -N-oxalyl-,-diaminopropionic acid (-ODAP).[Synonym -oxalylaminoalanine(BOAA)]

grass pea
Grasspea
  • Resist water shortage and water logging.
  • Improves soil fertility.
  • Needs no fertilizer.
  • Gives high yield.
history of neurolathyrism
History of Neurolathyrism
  • Ancient disease.
  • Often occurs in epidemics.
  • Several epidemics occurred in most parts of the world.
prevalence
Prevalence
  • Varies from country to country.
  • Often occur in inaccessible areas.
  • Not many epidemiological studies.
mean prevalence
Mean Prevalence
  • Ethiopia 6 per 1000
  • India 5.3 per 1000
  • Bangladesh 1.4 per 1000.
recent epidemics
Recent epidemics
  • 1973 : China
  • 1976: Bangladesh
  • 1976: Ethiopia
  • 1998: Nepal (non published)
  • 1998: Afghanistan (non published)
  • 1997-99: Ethiopia
onset of the disease
Onset of the disease
  • Mostly 3-6 months.
  • Acute or chronic.
  • Dose dependent.
  • Critical level = 400gm/day.
risk factors
Risk factors
  • Heavy physical activity
  • Male gender
  • Young age (15-25 years)
  • Micro nutrient deficiency (Zn,Cu, Vit C, Vit A)
clinical features
Clinical features
  • Upper motor neuron disorder with symmetrical spastic paralysis.
  • Sensation and sphincters are spared.
stages of the disease
Stages of the disease
  • Stage I (No stick stage)
  • Stage II (One stick stage)
  • Stage III (Two sticks stage)
  • Stage IV (Crawler stage)
treatment
Treatment
  • No definitive treatment.
  • The neuronal damages are permanent.
  • Symptomatic treatment with muscle relaxants help.
prevention
Prevention
  • Home based detoxifying methods.
  • New seed lines.
  • Cultivation of alternate crops.
prevention1
Prevention

Although cultivation of the grass pea is legally banned

in India and Nepal,

Neurolathyrism continued to manifest itself.

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