Pharmaceutics research areas
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Pharmaceutics Research Areas. School of Pharmacy. Pharmaceutics Symmetry/Synergy. Pre-formulation/Formulation. Quality Control. Drug Delivery. FOUR Key Focus Areas.

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Pharmaceutics Research Areas

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Pharmaceutics research areas

Pharmaceutics Research Areas

School of Pharmacy


Pharmaceutics symmetry synergy

Pharmaceutics Symmetry/Synergy

Pre-formulation/Formulation

Quality Control

Drug Delivery


Four key focus areas

FOUR Key Focus Areas

  • Physico-chemical aspects of APIs and excipients for improved pre-formulation and formulation studies. Emphasis on polymorphism, cyclodextrin inclusion and co-crystallization of pharmaceutical ingredients

  • Drug delivery systems of poorly soluble drugs with emphasis on solid dosage forms and quality control

  • Transdermal permeation studies with emphasis on traditional medicinal compounds and the development of percutaneous absorption models for medicinal plants. Focus is placed on liposomal carrier systems and permeation enhancers.

  • Development and optimisation of nanoparticulate drug delivery systems using statistical experimental design with emphasis on improving physical and chemical stability.


Pharmaceutics research areas

  • Supramolecular chemistry study of non-covalent interactions between molecules, ions or radicals.

  • Hydrogen bonding, π···π, C-H···π, van der Waals and hydrophobic interactions.

    • Crystalline materials obtain fundamental physical properties from molecular arrangement within the solid

    • Altering the placement and/or interactions between these molecules directly impacts its physico-chemical properties

    • Solid-state chemists incorporate a variety of different strategies when attempting to modify the chemical and physical solid-state properties of APIs, namely, the formation of salts, polymorphs, hydrates, solvates, complexes and co-crystals


Physicochemical properties

Physicochemical properties


Analytical methods

Analytical METHODS

  • HSM

  • DSC

  • TG

  • Single X-ray analysis

  • PXRD

  • UV

  • TLC

  • HPLC

  • NMR

  • Microanalysis

  • FTIR & FTNIR

  • LC-MS


Post formulation

Post - Formulation

Physical & chemical characteristics & Quality control – solid dosage forms

  • Particle size & shape analysis – microscopy, Coulter Counter

  • Flowability

  • Pycnometry

  • Durability

  • Friability

  • Disintegration

  • Dissolution


Transdermal studies

Transdermal studies

  • Percutaneous absorption models

  • Liposomal carrier systems & permeation enhancers.

    • Human skin Preparation- Removal of Hypodermal and Epidermal layers.

    • Franz Diffusional - used for drug permeation through human skin & other membranes.


Nanoparticulate drug delivery

Nanoparticulate drug delivery

  • Nanoparticle such as liposomes are ideal drug carriers as they accumulate in disease or inflamed tissues.

  • Enables targeted delivery to these tissues.

  • Stability of nanoparticulate suspensions is problematic:

    • Use of statistical design such as response surface methodology (RSM) to optimise formulations for prolonged storage and delivery.


Researchers

Researchers

  • H Samsodien - Supramolecular synthesis & pre-formulation

  • R A Bapoo - Solid dosage forms

  • N Ebrahim- Transdermal drug delivery

  • G Kilian – Nanoparticulateoptimisation


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