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G lycolysis

Electron Transport Chain (E.T.C.) (Oxidative Phosphorylation). G lycolysis. glucose. ATP + Pyruvate + NADH. Pyruvate Conversion. CO 2 + acetyl CoA + NADH. Citric Acid Cycle. CO 2 + ATP + Oxaloacetate + NADH + FADH 2.

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G lycolysis

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  1. Electron Transport Chain (E.T.C.) (Oxidative Phosphorylation) Glycolysis glucose ATP + Pyruvate + NADH Pyruvate Conversion CO2 + acetylCoA + NADH Citric Acid Cycle CO2 + ATP + Oxaloacetate + NADH + FADH2

  2. Glycolysis Start materials: 1 glucose (C6H12O6) 2 NAD+ 2 ADP Location: Cytoplasm; accomplished in 10 enzymatically-catalyzed steps Generates/produces: 2 pyruvate 2 NADH 2 ATP (come from substrate-level phosphorylation; 4 ATP are made in total, but 2 ATP are used/invested initially to start the process – thus, a net gain of only 2 ATP is counted)

  3. Pyruvate Conversion Start materials: 2 pyruvate 2 NAD+ Location: Matrix of mitochondrion; enzymatically-catalyzed in 3 steps Generates/produces: 2 acetyl CoA 2 NADH 2 CO2

  4. Citric Acid (Kreb’s) Cycle Start materials: 2 acetyl CoA (join with 2 oxaloacetate) 6 NAD+ 2 FAD 2 ADP Location: Matrix of mitochondrion; accomplished in 8 enzymatically-catalyzed steps; completes one turn/rotation per acetyl CoA (with 2 acetyl CoA, two turns/rotations total are achieved Generates/produces: 4 CO2 6 NADH 2 FADH2 2 ATP (come from substrate-level phosphorylation 2 oxaloacetate

  5. E.T.C./Oxidative Phosphorylation Start materials: 10 NADH 2 FADH2 6 O2 28 ADP Location: Inner Mitochondrial Membrane (IMM), matrix of mitochondrion, and intermembrane space of mitochondrion Generates/produces: 10 NAD+ 2 FAD 12 H2O (6 molecules of water are consumed during various steps of glycolysis and Kreb’s Cycle, resulting in a net gain of only 6 H2O) 28 ATP* * 2.5 ATP x 10 NADH 1 NADH 1 1.5 ATP x 2FADH2 1 FADH2 1 = 25 ATP = 3 ATP = 28 ATP +

  6. Movement of electrons throughthe E.T.C. Intermembrane space Inner Mitochondrial Membrane (IMM) Complex I Cyt C Complex IV Q Complex II ATP Synth-ase Complex III 4 H+ 4 H+ Mitochondrial Matrix 2 H+

  7. Movement of electrons throughthe E.T.C. Intermembrane space Inner Mitochondrial Membrane (IMM) Complex I Cyt C Complex IV Q 2e- Complex II ATP Synth-ase Complex III NAD+ NADH 4 H+ 4 H+ Mitochondrial Matrix 2 H+

  8. Movement of electrons throughthe E.T.C. 4 H+ Intermembrane space Inner Mitochondrial Membrane (IMM) Complex I Cyt C Complex IV Q 2e- Complex II ATP Synth-ase Complex III 4 H+ Mitochondrial Matrix 2 H+

  9. Movement of electrons throughthe E.T.C. 4 H+ Intermembrane space Inner Mitochondrial Membrane (IMM) Complex I Cyt C Complex IV Q Complex II ATP Synth-ase Complex III 4 H+ Mitochondrial Matrix 2 H+

  10. Movement of electrons throughthe E.T.C. 4 H+ Intermembrane space Inner Mitochondrial Membrane (IMM) Complex I Cyt C Complex IV 2e- Q Complex II ATP Synth-ase Complex III 4 H+ Mitochondrial Matrix 2 H+

  11. Movement of electrons throughthe E.T.C. 4 H+ 4 H+ Intermembrane space Inner Mitochondrial Membrane (IMM) Complex I Cyt C Complex IV Q Complex II ATP Synth-ase Complex III Mitochondrial Matrix 2 H+

  12. Movement of electrons throughthe E.T.C. 4 H+ 4 H+ Intermembrane space Inner Mitochondrial Membrane (IMM) Complex I Cyt C Complex IV Q 2e- Complex II ATP Synth-ase Complex III 2H+ + ½ O2 H2O Mitochondrial Matrix 2 H+

  13. Movement of electrons throughthe E.T.C. 2 H+ 4 H+ 4 H+ Intermembrane space Inner Mitochondrial Membrane (IMM) Complex I Cyt C Complex IV Q Complex II ATP Synth-ase Complex III H2O Mitochondrial Matrix ADP + Pi

  14. Movement of electrons throughthe E.T.C. 2 H+ 4 H+ Intermembrane space Inner Mitochondrial Membrane (IMM) Complex I Cyt C Complex IV Q Complex II ATP Synth-ase Complex III H2O ATP Mitochondrial Matrix ADP + Pi 4 H+

  15. Movement of electrons throughthe E.T.C. 2 H+ Intermembrane space Inner Mitochondrial Membrane (IMM) Complex I Cyt C Complex IV Q Complex II ATP Synth-ase Complex III H2O 2 ATP Mitochondrial Matrix ADP + Pi 4 H+ 4 H+

  16. Movement of electrons throughthe E.T.C. Intermembrane space Inner Mitochondrial Membrane (IMM) Complex I Cyt C Complex IV Q Complex II ATP Synth-ase Complex III H2O 2.5 ATP Mitochondrial Matrix ADP + Pi 4 H+ 4 H+ 2 H+

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