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Introduction and Tissues. Human Anatomy BIOL 1010 Liston Campus. What is Anatomy?. Anatomy (= morphology): study of body’s structure Physiology: study of body’s function Structure reflects Function!!! Branches of Anatomy Gross: Large structures Surface: Landmarks

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Introduction and tissues l.jpg

Introduction and Tissues

Human AnatomyBIOL 1010

Liston Campus


What is anatomy l.jpg

What is Anatomy?

  • Anatomy (= morphology): study of body’s structure

  • Physiology: study of body’s function

  • Structure reflects Function!!!

  • Branches of Anatomy

    • Gross: Large structures

    • Surface: Landmarks

    • Histology: Cells and Tissues

    • Developmental: Structures change through life

    • Embryology: Structures form and develop before birth


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Hierarchy of Structural Organization

Each of these build upon one another to make up the next level:

  • Chemical level

  • Cellular

  • Tissue

  • Organ

  • Organ system

  • Organism


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Hierarchy of Structural Organization

  • Chemical level

    • Atoms combine to make molecules

    • 4 macromolecules in the body

      • Carbohydrates

      • Lipids

      • Proteins

      • Nucleic acids


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Hierarchy of Structural Organization

  • Cellular

    • Made up of cells and cellular organelles (molecules)

      • Cells can be eukaryotic or prokaryotic

      • Organelles are structures within cells that perform dedicated functions (“small organs”)

http://cmweb.pvschools.net/~bbecke/newell/Cells.html


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Hierarchy of Structural Organization

  • Tissue

    • Collection of cells that work together to perform a specialized function

    • 4 basic types of tissue in the human body:

      • Epithelium

      • Connective tissue

      • Muscle tissue

      • Nervous tissue

www.emc.maricopa.edu


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Hierarchy of Structural Organization

  • Organ

    • Made up of tissue

      • Heart

      • Brain

      • Liver

      • Pancreas, etc……

Pg 181


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Hierarchy of Structural Organization

  • Organ system (11)

    • Made up of a group of related organs that work together

      • Integumentary

      • Skeletal

      • Muscular

      • Nervous

      • Endocrine

      • Cardiovascular

      • Lymphatic

      • Respiratory

      • Digestive

      • Urinary

      • Reproductive

Circulatory

Pg 341

Urinary System


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Hierarchy of Structural Organization

  • Organism

    • An individual human, animal, plant, etc……

    • Made up all of the organ systems

    • Work together to sustain life


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Anatomical Directions

  • Anatomical position

  • Regions

    • Axial vs. Appendicular

  • Anatomical Directions-It’s all Relative!

    • Anterior (ventral) vs. Posterior (dorsal)

    • Medial vs. Lateral

    • Superior (cranial) vs. Inferior (caudal)

    • Superficial vs. Deep

    • Proximal vs. Distal

  • Anatomical Planes

    • Frontal = Coronal

    • Transverse = Horizontal = Cross Section

    • Sagittal

Pg 5


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Reference Point


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4 Types of Tissue

  • Epithelium

  • Connective

  • Muscle

  • Nervous


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Tissues: groups of cells closely associated that have a similar structure and perform a related function

  • Four types of tissue

    • Epithelial = covering/lining

    • Connective = support

    • Muscle = movement

    • Nervous = control

  • Most organs contain all 4 types

  • Tissue has non-living extracellular material between its cells


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EPITHELIAL TISSUE: sheets of cells cover a surface or line a cavity

  • Functions

    • Protection

    • Secretion

    • Absorption

    • Ion Transport


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Characteristics of Epithelium

  • Cellularity

    • Composed of cells

  • Specialized contacts

    • Joined by cell junctions

  • Polarity

    • Apical vs. Basal surfaces differ

  • Supported by connective tissue

  • Avascular

  • Innervated

  • Highly regenerative


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Classification of Epithelium-based on number of layers and cell shape

  • Layers

    • Simple

    • Stratified

      • Stratified layers characterized by shape of apical layer

    • Psuedostratified

  • Shapes

    • Squamous

    • Cuboidal

    • Columnar

    • Transitional


Types of epithelium l.jpg

Simple squamous (1 layer)

Lungs, blood vessels, ventral body cavity

Simple cuboidal

Kidney tubules, glands

Simple columnar

Stomach, intestines

Pseudostratified columnar

Respiratory passages (ciliated version)

Stratified squamous (>1 layer)

Epidermis, mouth, esophagus, vagina

Named so according to apical cell shape

Regenerate from below

Deep layers cuboidal and columnar

Transitional (not shown)

Thins when stretches

Hollow urinary organs

Types of Epithelium

All histology pictures property of BIOL 1010 Lab


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Endothelium

Simple squamous epithelium that lines vessels

e.g. lymphatic & blood vessel

Mesothelium

Simple squamous epithelium that forms the lining of body cavities

e.g. pleura, pericardium, peritoneum

Special Epithelium


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Features of Apical Surface of Epithelium

  • Microvilli:(ex) in small intestine

    • Finger-like extensions of the plasma membrane of apical epithelial cell

    • Increase surface area for absorption

  • Cilia: (ex) respiratory tubes

    • Whip-like, motile extension of plasma membrane

    • Moves mucus, etc. over epithelial surface 1-way


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Features of Lateral Surface of Epithelium

  • Cells are connected to neighboring cells via:

    • Contour of cells-wavy contour fits together

    • Cell Junctions (3 common)

      • Desmosomes

        • Proteins hold cells together to maintain integrity of tissue

      • Tight Junctions

        • Plasma membrane of adjacent cells fuse, nothing passes

      • Gap junction

        • Proteins allow small molecules to pass through


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Features of the Basal Surface of Epithelium

  • Basement membrane

    • Sheet between the epithelial and connective tissue layers

    • Attaches epithelium to connective tissue below

    • Made up of:

      • Basal lamina: thin, non-cellular, supportive sheet made of proteins

        • Superficial layer

        • Acts as a selective filter

        • Assists epithelial cell regeneration by moving new cells

      • Reticular fiber layer

        • Deeper layer

        • Support


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Glands

  • Epithelial cells that make and secrete a product

  • Products are water-based and usually contain proteins

  • Classified as:

    • Unicellular vs. multicellular

    • Exocrine vs. Endocrine

Page 138


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Glands: epithelial cells that make and secrete a water-based substance w/proteins

  • Exocrine Glands

    • Secrete substance onto body surface or into body cavity

    • Activity is local

    • Have ducts

    • Unicellular or Multicellular

    • (ex) goblet cells, salivary, mammary, pancreas, liver


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Glands: epithelial cells that make and secrete a water-based substance w/proteins

  • Endocrine Glands

    • Secrete product into blood stream

    • Either stored in secretory cells or in follicle surrounded by secretory cells

    • Hormones travel to target organ to increase response (excitatory)

    • No ducts

    • (ex) pancreas, adrenal, pituitary, thyroid


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4 Types of Tissue

  • Epithelium

  • Connective

  • Muscle

  • Nervous


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4 Types of Connective Tissue

Connective Tissue Proper

Cartilage

Bone Tissue

Blood


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Connective Tissue (CT): most abundant and diverse tissue

  • Four Classes

  • Functions include connecting, storing & carrying nutrients, protection, fight infection

  • CT contains large amounts of non-living extracellular matrix

  • Contains a variety of cells and fibers

  • Some types vascularized

  • All CT originates from mesenchyme

    • Embryonic connective tissue


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Fibers in Connective Tissue

  • Fibers For Support

    • Reticular:

      • form networks for structure & support

      • (ex) cover capillaries

    • Collagen:

      • strongest, most numerous, provide tensile strength

      • (ex) dominant fiber in ligaments

    • Elastic:

      • long + thin, stretch and retain shape

      • (ex) dominant fiber in elastic cartilage


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Components of Connective Tissue

  • Fibroblasts:

    • cells that produce all fibers in CT

    • produce + secrete protein subunits to make them

    • produce ground matrix

  • Interstitial (Tissue) Fluid

    • derived from blood in CT proper

    • medium for nutrients, waste + oxygen to travel to cells

    • found in ground matrix

  • Ground Matrix (substance):

    • part of extra-cellular material that holds and absorbs interstitial fluid

    • Made and secreted by fibroblasts

    • jelly-like with sugar & protein molecules


1 connective tissue proper l.jpg

1) Connective Tissue Proper

  • Two kinds: Loose CT & Dense CT

    • Functions

      • Support and bind to other tissue

      • Hold body fluids

      • Defends against infection

      • Stores nutrients as fat

    • Each function performed by different kind of fibers and cells in specific tissue


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Defense from Infection

  • Areolar tissue below epithelium is body’s first defense

  • Cells travel to CT in blood

    • Macrophages-eat foreign particles

    • Plasma cells-secrete antibodies, mark molecules for destruction

    • Mast cells-contain chemical mediators for inflammation response

    • White Blood Cells = neutrophils, lymphocytes, eosinophils-fight infection

  • Ground substance + cell fibers-slow invading microorganisms


Loose ct proper l.jpg

Areolar CT

All types of fibers present

All typical cell types present

Surrounds blood vessels and nerves

Loose CT Proper


Specialized loose ct proper l.jpg

Adipose tissue

Loaded with adipocytes, highly vascularized, high metabolic activity

Insulates, produces energy, supports

Found in hypodermis under skin

Reticular CT

Contains only reticular fibers

Forms caverns to hold free cells, forms internal “skeleton” of some organs

Found in bone marrow, holds blood cells, lymph nodes, spleen

Specialized Loose CT Proper


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Dense/Fibrous Connective Tissue

  • Contains more collagen

  • Can resist extremely strong pulling forces

  • Regular vs. Irregular

    • Regular-fibers run same direction, parallel to pull

      • (eg) fascia, tendons, ligaments

    • Irregular-fibers thicker, run in different directions

      • (eg) dermis, fibrous capsules at ends of bones

Denseregular

Denseirregular


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Components of CT Proper Summarized


2 cartilage l.jpg

2) Cartilage

  • Chondroblastsproduce cartilage

  • Chondrocytes mature cartilage cells

    • Reside in lacunae

  • More abundant in embryo than adult

  • Firm, Flexible

  • Resists compression

    • (eg) trachea, meniscus

  • Avascular (chondrocytes can function w/ low oxygen)

  • NOT Innervated

  • Perichondrium

    • dense, irregular connective tissue around cartilage

    • growth/repair of cartilage

    • resists expansion during compression of cartilage


Cartilage in the body l.jpg

Cartilage in the Body

  • Three types:

    • Hyaline

      • most abundant

      • fibers in matrix

      • support via flexibility/resilience

      • (eg) at limb joints, ribs, nose

    • Elastic

      • many elastic fibers in matrix too

      • great flexibility

      • (eg) external ear, epiglottis

    • Fibrocartilage

      • resists both compression and tension

      • (eg) meniscus, annulus fibrosus


Components of cartilage summarized l.jpg

Components of Cartilage Summarized


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3) Bone Tissue: (a bone is an organ)

  • Well-vascularized

  • Function:

    • support (eg) pelvic bowl, legs

    • protect (eg) skull, vertebrae

    • mineral storage (eg) calcium, phosphate (inorganic component)

    • movement (eg) walk, grasp objects

    • blood-cell formation (eg) red bone marrow


Bone tissue l.jpg

Bone Tissue

  • Osteoblasts

    • Secrete organic part of bone matrix

  • Osteocytes

    • Mature bone cells

    • Sit in lacunae

    • Maintain bone matrix

  • Osteoclasts

    • Degrade and reabsorb bone

  • Periosteum

    • External layer of CT that surrounds bone

      • Outer: Dense irregular CT

      • Inner: Osteoblasts, osteoclasts

  • Endosteum

    • Internal layer of CT that lines cavities and covers trabeculae

    • Contains osteoblasts and osteoclasts

academic.kellogg.cc.mi.us/.../skeletal.htm


Compact bone l.jpg

External layer

Osteon (Haversian system)

Parallel to the long axis of the bone

Groups of concentric tubules (lamella)

Lamella = layer of bone matrix where all fibers run in the same direction

Adjacent lamella fibers run in opposite directions

Haversian Canal runs through center of osteon

Contains blood vessels and nerves

Connected to each other by perforating (Volkman) canals

Interstitial lamellae fills spaces and forms periphery

Compact Bone

www.mc.vanderbilt.edu/.../CartilageandBone03.htm


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Bone Anatomy: Spongy bone

  • Spongy bone (cancellous bone): internal layer

    • Trabeculae: small, needle-like pieces of bone form honeycomb

      • each made of several layers of lamellae + osteocytes

      • no canal for vessels

      • space filled with bone marrow

      • not as dense, no direct stress at bone’s center


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Shapes of Bones

  • Flat = skull, sternum, clavicle

  • Irregular = pelvis, vertebrae

  • Short = carpals, patella

  • Long = femur, phalanges, metacarpals, humerus


Anatomy of a long bone l.jpg

Anatomy of a Long Bone

  • Diaphysis

    • Medullary Cavity

    • Nutrient Artery & Vein

  • 2 Epiphyses

    • Epiphyseal Plates

    • Epiphyseal Artery & Vein

  • Periosteum

    • Does not cover epiphyses

  • Endosteum

    • Covers trabeculae of spongy bone

    • Lines medullary cavity of long bones

training.seer.cancer.gov/.../illu_long_bone.jpg


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2 Types of Bone Formation

  • Intramembranous Ossification

    • Membrane bones: most skull bones and clavicle

    • Osteoblasts in membrane secrete osteoid that mineralizes

  • Endochondral Ossification: All other bones

    • Begins with a cartilaginous model

    • Cartilage calcifies

    • Medullary cavity is formed by action of osteoclasts

    • Epiphyses grow and eventually calcify

      • Epiphyseal plates remain cartilage for up to 20 years


Bone growth remodeling l.jpg

Bone Growth & Remodeling

  • GROWTH

    • Appositional Growth = widening of bone

      • Bone tissue added on surface by osteoblasts of periosteum

      • Medullary cavity maintained by osteoclasts

    • Lengthening of Bone

      • Epiphyseal plates enlarge by chondroblasts

      • Matrix calcifies (chondrocytes die and disintegrate)

      • Bone tissue replaces cartilage on diaphysis side

  • REMODELING

    • Due to mechanical stresses on bones, their tissue needs to be replaced

      • Osteoclasts-take up bone ( = breakdown) release Ca2++ , PO4 to body fluids from bone

      • Osteoblasts-form new bone by secreting osteoid

    • Ideally osteoclasts& osteoblastswork at the same rate!


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Components of Bone Tissue Summarized


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4) Blood: Atypical Connective Tissue

  • Function:

    • Transports waste, gases, nutrients, hormones through cardiovascular system

    • Helps regulate body temperature

    • Protects body by fighting infection

  • Derived from mesenchyme

  • Hematopoiesis: production of blood cells

    • Occurs in red bone marrow

    • In adults, axial skeleton, girdles, proximal epiphyses of humerus and femur


Blood cells l.jpg

Blood Cells

  • Erythrocytes: (RBC) small, oxygen-transporting

    • most abundant in blood

    • no organelles, filled w/hemoglobin

    • pick up O2 at lungs, transport to rest of body

  • Leukocytes: (WBC) complete cells , 5 types

    • fight against infectious microorganisms

    • stored in bone marrow for emergencies

  • *Platelets = Thrombocytes:

    • fragments of cytoplasm

    • plug small tears in vessel walls, initiates clotting


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Components of Blood Summarized


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4 Types of Tissue

  • Epithelium

  • Connective

  • Muscle

  • Nervous


Muscle tissue l.jpg

Muscle Tissue

  • Muscle cells/fibers

    • Elongated

    • Contain many myofilaments: Actin & Myosin

  • FUNCTION

    • Movement

    • Maintenance of posture

    • Joint Stabilization

    • Heat Generation

  • Three types: Skeletal, Cardiac, Smooth


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Skeletal Muscle Tissue(each skeletal muscle is an organ)

  • Cells

    • Long and cylindrical, in bundles

    • Multinucleate

    • Obvious Striations

  • Skeletal Muscles-Voluntary

  • Connective Tissue Components:

    • Endomysium-surrounds fibers

    • Perimysium-surrounds bundles

    • Epimysium-surrounds the muscle

  • Attached to bones, fascia, skin

  • Origin & Insertion

academic.kellogg.cc.mi.us/.../muscular.htm


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Cardiac Muscle

  • Cells

    • Branching, chains of cells

    • Single or Binucleated

    • Striations

    • Connected by Intercalated discs

  • Cardiac Muscle-Involuntary

  • Myocardium-heart muscle

    • Pumps blood through vessels

  • Connective Tissue Component

    • Endomysium: surrounding cells

www.answers.com


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Smooth Muscle Tissue

  • Cells

    • Single cells, uninucleate

    • No striations

  • Smooth Muscle-Involuntary

    • 2 layers-opposite orientation (peristalsis)

  • Found in hollow organs, blood vessels

  • Connective Tissue Component

    • Endomysium: surrounds cells


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4 Types of Tissue

  • Epithelium

  • Connective

  • Muscle

  • Nervous


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Nervous Tissue

  • Neurons: specialized nerve cells conduct impulses

    • Cell body, dendrite, axon

  • Characterized by:

    • No mitosis (cell replication)

    • Longevity

    • High metabolic rate

www.morphonix.com


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Nervous Tissue: control

  • Support cells (= Neuroglial): nourishment, insulation, protection

    • Satellite cells-surround cell bodies within ganglia

    • Schwann cells-surround axons (PNS)

    • Microglia-phagocytes

    • Oligodendrocytes-produce myelin sheaths around axons

    • Ependymal cells-line brain/spinal cord, ciliated, help circulate CSF

  • Brain, spinal cord, nerves


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Integumentary System

  • Functions

    • Protection

      • Mechanical, thermal, chemical, UV

    • Cushions & insulates deeper organs

    • Prevention of water loss

    • Thermoregulation

    • Excretion

      • Salts, urea, water

    • Sensory reception


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Microanatomy - Layers of the Skin

  • Epidermis

    • Epithelium

  • Dermis

    • Connective tissue

  • Hypodermis / subcutis

    • Loose connective tissue

    • Anchors skin to bone or muscle

  • Skin Appendages = outgrowths of epidermis

    • Hair follicles

    • Sweat and Sebaceous glands

    • Nails

www.uptodate.com/.../Melanoma_anatomy.jpg


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Stratum corneum

Dead keratinocytes

Stratum lucidum

Only in “thick” skin

Dead keratinocytes

Stratum granulosum

Water proofing

Stratum spinosum

Resists tears and tension

Stratum basale

Sensory receptors

Melanocytes

Keratinocytes (in all layers)

Cell Layers of the Epidermis

15minbeauty.blogspot.com


Layers of the dermis l.jpg

Highly innervated

Highly vascularized

Collagen & Elastic fibers

2 layers:

Papillary layer (20%)

Areolar CT

Collagen & Elastic fibers

Innervation

Hair follicles

Reticular layer (80%)

Dense irregular CT

Glands

sebum

2.5 million sweat glands!!

Smooth muscle fibers

Innervation

Layers of the Dermis

www.uptodate.com/.../Melanoma_anatomy.jpg


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Hypodermis

  • Also called superficial fascia

  • Areolar & Adipose Connective Tissue

  • Functions

    • Store fat

    • Anchor skin to muscle, etc.

    • Insulation


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Structure of Tubular Organs

LUMEN

  • Tunica Mucosa

    • Lamina epithelialis

    • Lamina propria

    • Lamina muscularis mucosa

  • Tunica Submucosa

  • Tunica Muscularis

    • Inner circular

    • Outer longitudinal

  • Tunica Adventitia / Serosa

    • Adventitia – covers organ directly

    • Serosa – suspends organ in the peritoneal cavity


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