1 / 22

Lessons from Practice in HIV Scale-Up IAS Education Programme ICASA 2008

Lessons from Practice in HIV Scale-Up IAS Education Programme ICASA 2008. Debrework Zewdie Director Global AIDS Program The World Bank. Dakar, Senegal December 2, 2008. Overview. Historical context of scale up of treatment in Africa

laith-nunez
Download Presentation

Lessons from Practice in HIV Scale-Up IAS Education Programme ICASA 2008

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Lessons from Practice in HIV Scale-Up IAS Education Programme ICASA 2008 Debrework Zewdie Director Global AIDS Program The World Bank Dakar, Senegal December 2, 2008

  2. Overview • Historical context of scale up of treatment in Africa • Current challenges to further expansion and sustainability • Operational research garners evidence to ensure sustainability – examples • Role of donors and partners to coordinate and support research and to promote learning • Conclusion

  3. Number of people receiving antiretroviral drugs in low- and middle-income countries 2002−2007 3.0 2.8 North Africa and the Middle East Millions 2.6 2.4 2.2 Eastern Europe & Central Asia 2.0 1.8 1.6 East, South and South-East Asia 1.4 1.2 Latin America and the Caribbean 1.0 0.8 0.6 Sub-Saharan Africa 0.4 0.2 0.0 end- 2002 end- 2003 end- 2004 end- 2005 end- 2006 end- 2007 Year Source: Data provided by UNAIDS & WHO, 2008. 5.2

  4. Total annual resources available for AIDS 1986–2007 10 billion 10 000 8.9 billion 9000 US$ million Signing of Declaration of Commitment on HIV/AIDS,UNGASS 8000 8.3 billion 7000 6000 World Bank MAP launch 5000 4000 Gates Foundation PEPFAR 3000 UNAIDS Less than US$ 1 million 2000 1623 1000 Global Fund 292 257 212 59 0 2006 2007 1986 1987 1990 1991 1992 1993 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 Notes: [1] 1986-2000 figures are for international funds only; [2] Domestic funds are included from 2001 onwards [i]1996-2005 data: Extracted from 2006 Report on the Global AIDS Epidemic (UNAIDS, 2006); [ii] 1986-1993 data: Mann.&. Tarantola, 1996 Source: UNAIDS & WHO unpublished estimates, 2007 7.1

  5. Bilateral & multilateral resources available for HIV-related programmes in 2006 Global resources available for HIV-related programmes in 2006(US$ Billions) Bilateral disbursements to HIV-related programmes in 2006 (OECD/DAC statistics) 10 9 Other DAC country members 1% (US$ Billions) EC (0.5%) Belgium 1% 8 Spain 1% UN (2%) 7 Norway 2% 6 Australia 2% GFATM (7%) Germany 2% 5 Foundations (11%) Canada 2% 4 Sweden 3% Bilaterals (33%) Netherlands 3% 3 Domestic Public and Private (46%) Ireland 3% 2 United Kingdom 9% 1 United States 71% 0 Global resources available: US$8.9 Billion Percentage out of the total bilateral disbursements Total Bilateral disbursements 2006: US$ 2.9 Billion The organizational disbursements are different than commitments or obligations, as well as different from in-country expenditures Source: UNAIDS analysis based on OECD/DAC online database (last visited on May 6, 2008), Resource availability UNAIDS 2005, Funders Concerned About AIDS (FCAA), European HIV/AIDS Funders Group (EFG) for Philanthropic sector G

  6. Current challenges (1)

  7. The Face of Treatment is Changing… Current challenges (2) • Dr. Mari Kitahata at Univ. of Washington recently compared patients who started ART with a CD4 below 350 cells/mm3 to those started between 350-500 cells/mm3. The later initiators had a 71% increased risk of death (relative hazard of 1.7; C.I. 1.4 – 2.1). • Reported on October 27 2008 at Interscience Conference on Antimicrobial Agents and Chemotherapy; will appear in Journal of Infectious Disease Dec. 2008 • Used 22 U.S. and Canadian cohorts; 8374 “healthy” HIV patients from the International Epidemiology Databases to Evaluate AIDS • Studies are ongoing comparing starting with CD4 > 500 with starting CD 4 = 350 - 500 cells/mm3. Attribution: Dr. Jon Simon, Boston University

  8. Other Major Challenges • Funding increases cannot be infinite, donor dependence makes these unpredictable • Late enrollment and early mortality • Treatment failure and the expense of second line therapy • Limited integration with other treatment services (especially TB)

  9. The role of research in sustaining HIV Treatment programs • Discovery of better drugs • Understanding our epidemics • Operational Research • Cost-effectiveness research

  10. Operational Research in Treatment Programs • Evidence is vital for good strategic planning • Research can be an engine of excellence and capacity building • Research for activism and ownership • Clinical research – an essential tool to support programs

  11. The Sydney Declaration “Ten per cent of all resources dedicated to HIV programming should be used for research towards optimizing interventions utilized and health outcomes achieved”

  12. Optimizing Treatment approaches and effectiveness Integration of services Greater understanding of social, political and cultural barriers Integration of new therapies, technologies and guidelines Sustainability. success and cost effectiveness Priority Research Needs

  13. Treatment Acceleration Project (1) • Goal – pilot strategies for strengthening countries’ capacity to scale-up care and treatment programs that are efficient, affordable and equitable • Piloted in Ghana, Burkina Faso and Mozambique, 2004-2008 • 3 components: • Test approaches to scaling-up AIDS care and treatment • Strengthen institutional capacity for AIDS care and treatment • Facilitate regional learning • Technical support from WHO, UNECA (UN Economic Commission on Africa)

  14. Treatment Acceleration Project (2) • The TAP included a strong operational research / learning component, with regular meetings to share findings and resolve common challenges • Impact evaluations explored: • Factors that affect adherence • Impact of increased treatment access on prevention and risk behavior of patients, family members, and society • Impact of ART on individual and family well-being (health expenditures, assets, incomes, life expectancy, poverty, living standards, childrens’ schooling & nutrition • Impact of AIDS funding on quality and access to other health services (facililty and patient surveys)

  15. Addressing Knowledge Gaps in the Public Health Approach to Delivering Antiretroviral Therapy and Care • Two day consultation, March 2008 convened by WHO and cosponsored by IAS, World Bank and GFATM • Clinicians, community advocates, programme managers, researchers, donors and normative agency representatives • To identify gaps in policy relevant and operational research, barriers and opportunities: ART, non-ART care, Lab Services and Health Systems • Emphasis on Treatment through the Public Health Approach

  16. WHO ConsultationResearch Gaps - ART • When is the optimal time to initiate treatment? • What are the most effective strategies for improving adherence and the durability of first-line regimens? • When is the optimal time for switching to second-line regimens? • What role should laboratory monitoring play in clinical management? • What is the potential impact of new drugs/drug classes on first and second-line regimens? • What is the impact of ART and other care/treatment interventions on preventing HIV transmission? • Delivering care and treatment to special populations, such as injecting drug users • Pediatric ART • Integration of TB and HIV treatment programs

  17. WHO ConsultationResearch Gaps - Health Systems • Optimal service delivery approaches for HIV treatment and care interventions • What is the impact of HIV ART care and treatment on the overall health care system? • How can the public health approach to delivering HIV interventions strengthen health care systems? • What costing, and cost-effectiveness analyses, are required to inform the optimal preventive and therapeutic service delivery strategies?

  18. WHO ConsultationResearch Gaps - Challenges • Lack of political commitment • Weak links between researchers and policymakers to help set a policy-relevant research agenda • Lack of funding • The lack of adequately trained staff with research expertise • Poor physical research infrastructure • Slow adoption and implementation of new technologies

  19. WHO ConsultationResearch Gaps - Opportunities • Invest in building research capacity (human resources and infrastructure) • Strengthen health information systems to capture information that will be used for decision-making; • Consider developing regional "centres of excellence" to foster and support regional and national research; • Expand north/south and south/south research collaboration and networks • Strengthen links between researchers and policymakers, possibly with a national coordinating body, to help set a policy-relevant research agenda • Invest in community engagement -- define and support a role for the community in designing and implementing research; • Strengthen coordination between granting agencies and HIV programmes.

  20. WHO Consultation Partner Commitments WHO, World Bank, GFATM, IAS agreed to advocate for: • Funding and implementation of Operations Research • Collaboration with countries to encourage greater investment in policy-relevant research • Collaboration with international agencies and countries to develop the research capacity of low- and middle-income countries and to use the results of this research • Contribute resources in co-sponsoring a session on research in Mexico and a follow-up summit in Vancouver in Feb 2009

  21. Conclusion • Treatment sustainability is not assured • Evidence is essential to preserve and expand our gains and operational research can provide this evidence • Research – especially operational research, which uses tools from epidemiological, social and clinical research – can deliver this evidence, but requires substantially increased support

  22. Thank you

More Related