Immune response to hiv infection
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Immune Response to HIV Infection. June 28, 2001 Ms. Jane Coyle-Morris Wyeth-Ayerst Research. Immune Response to HIV Infection. Immunology HIV Biology Immune Response to HIV Infection. Role of Antibodies. Antibody interaction with Complement Proteins. Cytotoxic T-Cells.

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Immune Response to HIV Infection

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Immune response to hiv infection

Immune Response to HIV Infection

June 28, 2001

Ms. Jane Coyle-Morris

Wyeth-Ayerst Research


Immune response to hiv infection1

Immune Response to HIV Infection

  • Immunology

  • HIV Biology

  • Immune Response to HIV Infection


Immune response to hiv infection

Role of Antibodies


Immune response to hiv infection

Antibody interaction with Complement Proteins


Immune response to hiv infection

Cytotoxic T-Cells


Immune response to hiv infection

Central Role of Helper T-Cells


Immune response to hiv infection

Macrophage

Large, irregularly-shaped phagocytic cells that act as the body’s scavengers. Macrophages engulf and consume foreign material such as bacteria and viruses.


T cells

T Cells

Arise from stem cells in the bone marrow then migrate to the thymus gland where they develop the ability to recognize foreign antigens in a specific manner.


Helper t cells t h

Helper T Cells (TH)

Detect infection and initiate both humoral and cell-mediated responses (CD4 cells)


Cytotoxic t cells t c

Cytotoxic T Cells (TC)

Recruited by TH to lyse infected body cells (CD8 cells)


Cell marker proteins

Cell Marker Proteins

  • CD4: cell marker found on the surface of TH and macrophages; acts as a receptor for HIV

  • CD8: cell marker found on the surface of TC


B cells and plasma cells

B Cells and Plasma Cells

  • B Cells: precursors of plasma cells, specialized to recognize particular foreign antigens

  • Plasma Cells: derived from B cells, they produce antibodies to specific antigens marking them for destruction


Major histocompatibility complex mhc

Major Histocompatibility Complex (MHC)

  • Proteins markers found on the surface of the body’s cells to signal “self” from “non-self”. MHC-I can be found on every cell in the body while MHC-II is found only on B cells, T cells and macrophages.


Cytokines

Cytokines

  • Soluble proteins secreted by the cells of the immune system to signal activation and proliferation of the appropriate components of the immune response. IL-1 is released from macrophages and signals activation of T cells. Activated T cells produce IL-2 which signals proliferation of T cell clones and also helps B cells to start secreting antibodies.


Cytokines1

Cytokines


The immune response

The Immune Response


Central role of cd4 t cell

Central Role of CD4 T Cell


Hiv biology

HIV Biology


Hiv in action

HIV in Action


Natural course of hiv infection

Natural Course of HIV Infection


Overview

Overview


Immune response to hiv infection2

Immune Response to HIV Infection

  • Immunology: humoral vs. cell-mediated

  • HIV biology: complex series of events leading to viral entry and course of infection; evasion of immune system

  • Immune response to HIV: weak humoral response, strong cell-mediated response diminished over time by depletion of helper T-cells


Aids hiv internet sites

AIDS/HIV Internet Sites

  • Www.ama-assn.org/special/hiv/hivhome.htm

  • www.planetq.com/aidsvl/index.html

  • www.thebody.com/cgi-bin/body.cgi

  • www.cdc.gov/

  • www.pbs.org/wgbh/nova/aids/

  • www.roche-hiv.com/default.htm


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