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By the end of this session you should know: How to classify T cell lymphoma PowerPoint PPT Presentation


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By the end of this session you should know: How to classify T cell lymphoma The clinical and pathological features of Anaplastic large T cell lymphoma Mycosis fungoides. Precursor B cell Acute lymphoblastic lymphoma Peripheral B cell

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By the end of this session you should know: How to classify T cell lymphoma

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By the end of this session you should know how to classify t cell lymphoma

  • By the end of this session you should know:

    • How to classify T cell lymphoma

    • The clinical and pathological features of

      • Anaplastic large T cell lymphoma

      • Mycosis fungoides


Classification of non hodgkin lymphoma selected common entities

Precursor B cell

Acute lymphoblastic lymphoma

Peripheral B cell

Small lymphocytic lymphoma SLL, Chronic lymphocytic leukemia CLL

Mantle cell lymphoma

Follicular lymphoma

Marginal zone lymphoma

Diffuse large B cell lymphom

Burkitt lymphoma

Precursor T cell

Acute lymphoblastic lymphoma

Peripheral T cell

Anaplastic large T cell lymphoma

Peripheral T cell lymphoma

Mycosis fungoides

Classification of Non-Hodgkin Lymphoma (selected common entities)


T cell lymphoma nk cell lymphoma

T cell lymphoma/ NK cell lymphoma

  • Rare (less common than B cell lymphoma)

  • TCR: alpha,Beta Gamma,delta

  • Alpha,Beta: helper and cytotoxic

  • Gamma,delta: 1st line of immunity

  • NK cells

  • Clonality


T cell lymphoma nk cell lymphoma1

T cell lymphoma/ NK cell lymphoma

  • Generally aggressive tumors

  • Clinically can be: nodal, extranodal, cutaneous, leukemic

  • More common in Asia

  • HTLV1 (Japan, Caribbean)

  • Treatment?


Anaplastic large t cell lymphoma

Anaplastic large T cell lymphoma

  • Clinical: Systemic, Cutaneous

    • Systemic can be Alk1 pos or Alk1 neg

  • Aggressive

  • Pathology: mixture of cells, Hallmark cells: large cells with horseshoe nucleus.

  • Immuno: CD3, CD30, Alk1 +/-

  • Genetic: t(2;5) NPM-Alk1 fusion product


Mycosis fungoides

Mycosis Fungoides

  • Epidermotropic T cell lymphoma characterized by a proliferation of small or medium-sized neoplastic T lymphocytes with cerebriform nuclei

  • Indolent clinical course

    • Elderly, limited to skin (progress late the course) scaly eruption

    • slow progression over years

    • patches, plaques, tumors, lymph node, internal organs


Pathology

Pathology

  • Epidermotropic, band-like infiltrates involving the papillary dermis

  • small, medium-sized, and occasionally large mononuclear cells

  • hyperchromatic, indented (cerebriform) nuclei

  • Pautrier’s microabscesses


By the end of this session you should know how to classify t cell lymphoma

  • CD3+, CD4+

  • 5-year survival 87%

  • Therapy:

    • confined to skin: skin-targeted therapies, phototherapy, topical nitrogen mustard, radiotherapy

  • Progression to CD30+ or CD30- Large T-cell lymphoma


Sezary s syndrome

Sezary’s Syndrome

  • Definition:

    • erythroderma, generalized lymphadenopathy, and the presence of neoplastic T cells in skin, lymph nodes and peripheral blood

  • Micro:

    • may be similar to MF

    • more often monotonous cells

    • CD3+, CD4+

  • Survival: 11%, Chemo is the treatment


By the end of this session you should know how to classify t cell lymphoma

  • Peripheral T cell lymphoma

  • Adult T cell lymphoma

  • Extranodal NK/T cell lymphoma of nasal type


By the end of this session you should know how to classify t cell lymphoma

  • By the end of this session you should know:

    • How to classify T cell lymphoma

    • The clinical and pathological features of

      • Anaplastic large T cell lymphoma

      • Mycosis fungoides


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