Glaucoma Research. Boosting optic nerve energy to slow glaucoma Ian Trounce Principal Investigator CERA Wagstaff Fellow RVEEH. The burden of glaucoma. 67 million world-wide 6 million estimated blind 7 million out-patient visits in the USA 150,000 people in Australia
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Boosting optic nerve energy to slow glaucoma
Principal Investigator CERAWagstaff Fellow RVEEH
Mitochondria: Power generators of our cells
- Maternal inheritance
Highly energetic nerve cells with long axonsare prone to age-related decline
The optic nerve
- Parkinson’s disease
Exercise (and fasting) allow old optic nerves to recover from a pressure injury
Mitochondrial energy generation is impaired in some glaucoma patients
Diet moderation and exercise improve optic nerve resilience
Is this due to increased mitochondrial ‘health’?
Genetic analysis of mitochondrial DNA in glaucoma subjects underway
Can we identify subjects with genetic markers who may respond to ‘mitochondrial boosting’ therapies?
Wagstaff Bequest (RVEEH)
DHB Foundation Brockhoff Foundation (ANZ Trustees) – Leber Optic Atrophy stem cell study
Mason Foundation (ANZ Trustees) – The ‘good’ Alzheimer protein & the ageing eye
Michael J. Fox Foundation for Parkinson’s disease – A mitochondrial PD model
National Health and Medical Research Council