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COMPANY PROFILE PARTNER FOR COOPERATION. VUOS. Where you can find us. 2. VUOS – PARTNER FOR COOPERATION. VUOS ownership. SYNTHESIA, a.s. VUOS, a.s. AGROFERT HOLDING, a.s. 100 %. 100 %. 3. VUOS – PARTNER FOR COOPERATION. History. 100% daughter company of Synthesia a.s.
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COMPANY PROFILE PARTNER FOR COOPERATION VUOS
Where you can find us 2 VUOS – PARTNER FOR COOPERATION
VUOS ownership SYNTHESIA, a.s. VUOS, a.s. AGROFERT HOLDING, a.s. 100% 100% 3 VUOS – PARTNER FOR COOPERATION
History 100% daughter company of Synthesia a.s. Foundation of Research Laboratories Affiliation of Synthesia´s R&D Voucher Privatisation New name – VUOS 1941 1997 2004 1952 1992 4 VUOS – PARTNER FOR COOPERATION
VUOS main businesses 1. R&D and Production of Fine Chemicals 2. Toxicology and Analytics 6 10 14 70 Employees Sales in % 5 VUOS – PARTNER FOR COOPERATION
The Certificates of VUOS • Certificate ČSN EN ISO 9001: 2009 (organic chemicals - syntheses development and manufacture) • Decision on Compliance with Principles of Good Manufacturing Practice in Control Laboratory • Certificates of Good Laboratory Practice in Test Facility (OECD GLP Principles - 1997) • Certificate of Accredited Certification Body for Certification of Products (EN 45011:1998) • Certificate of Accredited Testing Laboratory (EN ISO/IEC 17025:2005) 6 VUOS – PARTNER FOR COOPERATION
Strong Points • Educationstructureofemployees • VUOS is located in area of long-lastingchemical tradition andcomplete infrastructure • Cooperation with University of Pardubice Skilled – 25 % Secondary – 30% University degree – 36% Ph.D. degree – 9% 7 VUOS – PARTNER FOR COOPERATION
R&D, upscaling • Pharmaceutical intermediates • Intermediates for microelectronics • Custom syntheses of chemical specialities • Dyes and pigments for special application 8 VUOS – PARTNER FOR COOPERATION
R&D, upscaling Wide range of quantities Grams – in laboratory Kilograms – in kilolab unit Metric tons – in VUOS production plant Hundreds of MT – 9 VUOS – PARTNER FOR COOPERATION
VUOS ’s key chemistry Adamantane derivatives N-Heterocycles API Building Blocks VUOS ’s key technology Hydrogenation Phosgenation 10 VUOS – PARTNER FOR COOPERATION
VUOS ’s technology/manufacture expertiseincludes: acetylation aldolisation amidation alkylation amination amoxidation azocoupling benzoylation chiral synthesis chlorination chlorosulfonation Claisen condensation cross coupling reaction cyclisation decarboxylation elimination esterification Friedel-Crafts reaction Grignard reaction heterocyclic synthesis hydrolysis reactions neutralisation nitration nitriles syntheses oxidation – catalytic/chemical oxidation in liquid phase rearrangement reduction with hydrazine and sodium borohydride Sulfonation dehydrohalogenation diazotisation 11 VUOS – PARTNER FOR COOPERATION
Kilolab and Semi-Pilot Unit Phosgenation 2x reactors, 250 and 650 l 2x High performance rectification columns Laboratory phosgenation units from 1 to 30 litres 12 VUOS – PARTNER FOR COOPERATION
Kilolab and Semi-Pilot Unit Hydrogenation 3x autoclaves 100 l each, 60, 120 and 130bar, up to 200 ˚C, Hastelloy C clad 1x autoclave 300 l, 120 bar, 140˚C, Hastelloy C clad 1x autoclave 700 l, 100 bar, 200 ˚C, stainless steel 1x autoclave 1 000 l, 10 bar, 140 ˚C, stainlesssteel many autoclaves up to 10 l 13 VUOS – PARTNER FOR COOPERATION
Kilolab Unit Low temperature, RLi, RMgX, NaH 1 x glass reactor 50 l cooled down to – 80 ˚C 1x glasslined reactor for NaH reactions (250 l) 3x glass reactors 100l for RLi, Grignard reactions 14 VUOS – PARTNER FOR COOPERATION
Kilolab and Semi-Pilot Unit Multipurpose chemistry 20x glass reactors, 100 l each 6x glass lined reactors (200–1 500 l) 2x evaporators 50 l / h 4x stainless steel reactors (300–1 500 l) sufficient filtration and distillation capacity 15 VUOS – PARTNER FOR COOPERATION
Production Unit Production Equipment 45x glass lined reactors, total vol. 70 000 l (500–5 000 l) 13x stainless steel reactors, totalvol. 22 000 l (1 000–3,000 l) 8x High performance rectification columns sufficient filtration capacity (nutsches, centrifuges) computer controlled 16 VUOS – PARTNER FOR COOPERATION
Toxicology, Ecotoxicology and Analytics 17 VUOS – PARTNER FOR COOPERATION
Toxicology, Ecotoxicology and Analytics • REACH and CLP Services • Literaturesearch • Preparationofdossiers in IUCLID 5 • PreparationofChemicalSafety Report • Non-testingapproaches • (Q)SAR • Grouping/Read-across • Preparationof SDS • Classificationofsubstances and mixtures 18 VUOS – PARTNER FOR COOPERATION
Toxicology, Ecotoxicology and Analytics • Analyticalmethods • NMR Spectrometry • MassSpectrometry (LC/GC-MS) • ICP-AES • IR Spectrometry • Chromatography (HPLC, GC) • UV-VIS 19 VUOS – PARTNER FOR COOPERATION
Toxicology, Ecotoxicology and Analytics • Toxicologicaltests • In vivoand in vitro testsaccording • to the OECD or EU methods: • Acute toxicity • Skin and Eyeirritation • Sensibilisation • Repeated dose toxicity • Reproductive toxicity • Carcinogenicity • Mutagenicity 20 VUOS – PARTNER FOR COOPERATION
Toxicology, Ecotoxicology and Analytics • Ecotoxicologicaltests • Aquatic toxicity • Bioticdegradation • Abioticdegradation • Adsorption/desorption • Physico-chemicaltests • Information on physicochemicalpropertiesof substance 21 VUOS – PARTNER FOR COOPERATION
Contacts General Manager: Dr. Karel Novák Phone: +420 46 682 2550, fax: +420 46 682 2976 e-mail: karel.novak@vuos.com Sales Manager: Miloš Jesenský,Ph.D. Phone: +420 46 682 3300, fax: +420 46 682 2976 e-mail: milos.jesensky@vuos.com R&D: Alois Koloničný, Ph.D. Phone:+420 46 682 3156, fax: +420 46 682 3900 e-mail: alois.kolonicny@vuos.com Toxicology and Analytics: Viktor Mejstřík, Ph.D. Phone:+420 46 682 3127, fax: +420 46 682 2975 e-mail: viktor.mejstrik@vuos.com Process Engineering: Luboš Víšek Phone:+420 46 682 5790, fax: +420 46 682 3900 e-mail:lubos.visek@vuos.com 22 VUOS – PARTNER FOR COOPERATION
