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Angiostatin : A Novel Angiogenesis Inhibitor That Mediates the Suppression of Metastases by a Lewis Lung Carcinoma Michael S. O ’Reilly , Lars Holmgren , Yuen Shing , Catherine Chen , Rosallnd A. Rosenthal , Marsha Moses, William S. Lane , Yihai Cao,

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Angiostatin : A Novel Angiogenesis Inhibitor That Mediates the Suppression of Metastases

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Angiostatin: A Novel Angiogenesis Inhibitor

That Mediates the Suppression of Metastases

by a Lewis Lung Carcinoma

Michael S. O’Reilly,Lars Holmgren, Yuen Shing,

Catherine Chen, Rosallnd A. Rosenthal,

Marsha Moses, William S. Lane, Yihai Cao,

E. Helene Sage, and Judah Folkman

Cell, Vol. 79, 315-328, October 21, 1994


Lung carcinoma implanted subcutaneously into mice.

Allow to grow to 1500 mm3

Removed (or not) and wait 15 days

Look for metastases to lung


Same experiment, but now treat with serum or urine from tumor-bearing animal


Named this protein Angiostatin

Surprise! It’s a fragment of Plasminogen


Named this protein Angiostatin

Surprise! It’s a fragment of Plasminogen


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