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Surveillance and the Early Detection of Foot and Mouth Disease

Surveillance and the Early Detection of Foot and Mouth Disease. Melissa McLaws DVM – PhD Candidate, Dept of Population Medicine, University of Guelph Carl Ribble DVM, MSc, PhD – Advisor Craig Stephen DVM, PhD – Member of advisory committee

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Surveillance and the Early Detection of Foot and Mouth Disease

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  1. Surveillance and the Early Detection of Foot and Mouth Disease • Melissa McLaws DVM – PhD Candidate, Dept of Population Medicine, University of Guelph • Carl Ribble DVM, MSc, PhD – Advisor • Craig Stephen DVM, PhD – Member of advisory committee • Bruce McNab DVM, PhD – Member of advisory committee

  2. Foot and Mouth Disease (FMD) • Highly contagious disease of cloven-hoofed animals (including cattle, sheep, pigs) • Re-emerging disease? • Large outbreaks of disease have recently occurred in areas that had been free of disease for a long time (UK, Taiwan) • High profile • Concern as agent of bio-terrorism

  3. From FAO website

  4. FMD: Epidemiology • Infection by inhalation or ingestion of the virus • Spread on farm – direct contact, mechanical • Spread between farms – animal movements, fomites (people,vehicles, wildlife) • Wind-borne transmission (spread esp. by pigs, cattle esp. susceptible)

  5. FMD: Clinical Signs • Fever, depression, milk-drop • Lameness • Salivation • Vesicles in mouth, coronary band, teats • Ruptured vesicles…+/- secondary infection • Sudden death – young animals • Species differences (maybe subtle and transient in sheep/goats)

  6. FMD: Diagnosis • Currently, case identification is dependent on recognition of clinical signs (rather than screening with a lab test) • Non-endemic situation – passive surveillance • Epidemic (and endemic) situation- active and passive surveillance

  7. Non-Endemic Situation HIGH RISK PERIOD Disease circulating in endemic area Introduction to non-endemic area Detection of disease in non-endemic area Control Procedures Time

  8. Non-endemic Situation • Identified outbreaks of FMD in countries where the disease is not endemic from 1992-2002 • Literature review • Little information about how the outbreaks were found • Identify and describe factors that contributed to the final epidemic size

  9. Taiwan 1997 UK 2001; Uruguay 2001 Yugoslavia 1996; Greece 1994 # Infected Premises Italy 1993 Greece 1996 Netherlands 2001; Brazil 2000 S. Korea 2000 & 2002; Greece 2000 Japan 2000; S. Africa 2000; Swaziland 2000; Botswana 2002 & 2003; France 2001; Ireland 2001; Uruguay 2000; Argentina 2000; Bulgaria 1993

  10. Discussion • Most incursions of FMD virus lead to a relatively small outbreak, but on 3 occasions there was a big one: WHY? • Late detection? • Animal movement? • Virulent strain? • Animal density?

  11. Relationship Between Epidemic Size and Time to Report:

  12. Time since previous outbreak Education Veterinary Infrastructure Awareness Time from Infection to Detection Livestock demographics (density, type, husbandry) Unrestricted Animal Movement Level of Viral Shedding EPIDEMIC SIZE Species Affected Control - Methods and Effectiveness Viral Strain

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