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Postsynaptic Membrane PowerPoint PPT Presentation


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2+. 2+. Ca. out. Ca. Co-localization by ACh and SP. Presynaptic Terminal. Vesicle. Vesicle. Sp. ACh. v. v. S. Sp. ACh. f. f. ACh-E. SP. -Enz. Synaptic cleft. c. SP. c. ACh. c. Enz. E. SP. -R. NK1. ACh. R. c. SP. -R. p. NK1. R. NK3. c. Ion Channels. R.

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Postsynaptic Membrane

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Postsynaptic membrane

2+

2+

Ca

out

Ca

Co-localization by

ACh and SP

Presynaptic

Terminal

Vesicle

Vesicle

Sp

ACh

v

v

S

Sp

ACh

f

f

ACh-E

SP

-Enz

Synaptic cleft

c

SP

c

ACh

c

Enz

E

SP

-R

NK1

ACh

R

c

SP

-R

p

NK1

R

NK3

c

Ion Channels

R

NK3

Ion Channels

SP

-R

-G

c

NK1

G

ACh-R

PhC

PhC

i

a

P

Postsynaptic

Membrane

PkC

Dg

PkC

i

a

PPhos

P

+

IP

3

PIP

IP

-R

3

3

ER

R

ER

Pr

2+

Ca

ier

Endoplasmic

Reticulum


Postsynaptic membrane

Concomitant activation of the m 1 type ACh receptor, and …

… the NK1 type receptor

Effect of activation of the m 1 type ACh receptor


Postsynaptic membrane

Effect of activation of the m 1 type ACh receptor

Concomitant activation of the m 1 type (ACh) and NK 1 type receptors

Activation of the

NK 2 type receptor


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