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Cancer and LKB1

Cancer and LKB1. By: Rosanna Chan, Ria Shome, Chloe Ortbals, Alex Maynard, Michelle Reznikova. What is Cancer?. DNA malignant and benign cancer Current research. What is a Tumor S uppressor?. Anti-oncogene Checkpoints Checking e nergy homeostasis.

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Cancer and LKB1

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  1. Cancer and LKB1 By: Rosanna Chan, Ria Shome, Chloe Ortbals, Alex Maynard, Michelle Reznikova

  2. What is Cancer? • DNA • malignant and benign cancer • Current research

  3. What is a Tumor Suppressor? • Anti-oncogene • Checkpoints • Checking energy homeostasis

  4. Energy Homeostasisaka. Metabolic Stress • ATP & AMP • Anabolic pathways • ATP + small molecules => AMP + large molecule • Catabolic pathways • AMP + large molecule => ATP + smaller molecules

  5. AMPK Facts • Protein kinase • Metabolic stress (anabolic & catabolic)

  6. How is LKB1 a Tumor Suppressor? • -LKB1 and AMPK • energy homeostasis (AMP:ATP ) • -prevents cell from dividing if there is an imbalance • Cancerous cells • If LKB1 is absent the cell divides more often (PeutzJeghers Syndrome)

  7. Molecular Structure of LKB1 • Arg74= reduce catalytic activity -arginine • RESIDUES MUTATED IN PJS • Interaction with STRAD • CFT [311-347]= reduced catalytic activity • c-terminal flanking tail Arg74 Glu199 Asp208 Ser232 Thr230

  8. LKB1-STRAD-MO25 Complex Function

  9. STRAD Molecular Structure • - pseudokinase that helps activate LKB1 Gln251 Leu241 Gln286

  10. MO25 Molecular Structure Phe243 • scaffolding protein • Orients the activation loop of LKB1 Arg240

  11. How Does LKB1 Affect Us? • where it is expressed • PJS/Cancer

  12. To Conclude LKB1

  13. Citations • "Adenosine Monophosphate." ChemSpider. N.p., n.d. Web. 06 Dec. 2013. <http://www.chemspider.com/Chemical-Structure.5858.html>. • "Case Study: Thermodynamics of ATP." Chemwiki. N.p., n.d. Web. 06 Dec. 2013. <http://chemwiki.ucdavis.edu/Physical_Chemistry/Thermodynamics/Case_Studies/Case_Study:_Thermodynamics_of_ATP>. • Cell Cycle with Checkpoints. Digital image. N.p., n.d. Web. 5 Dec. 2013. <http://answers.tutorvista.com/145710/what-is-the-cell-cycle.html>. • Hardie, D. Grahame, and Dario Alessi. "LKB1 and AMPK and the cancer-metabolism link - ten years after." BMC Biology. N.p., n.d. Web. 4 Dec. 2013. <http://www.biomedcentral.com/1741-7007/11/36>. • StickFigure. Digital image. Portablestudios. N.p., n.d. Web. <http://portablestudios.com.au/?attachment_id=75#>. • Serine/threonine Kinase 11. Digital image. Wikipedia. N.p., n.d. Web. • Van Aalten, Daan, and Elton Zeqiraj. "Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation." ScienceMag. N.p., 5 Nov. 2009. Web. <http://www.sciencemag.org/content/326/5960/1707.full>. • "What Is Cancer?" What Is Cancer?N.p., n.d. Web. 04 Dec. 2013. <http://www.cancer.org/cancer/cancerbasics/what-is-cancer>.

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