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SMART Platform and API for Clinical Genomic Apps

SMART Platform and API for Clinical Genomic Apps. Gil Alterovitz Director, Biomedical Cybernetics Laboratory Assistant Professor, Harvard Medical School. 100 Most Influential People of the Millennium.

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SMART Platform and API for Clinical Genomic Apps

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  1. SMART Platform and API for Clinical Genomic Apps Gil Alterovitz Director, Biomedical Cybernetics Laboratory Assistant Professor, Harvard Medical School

  2. 100 Most Influential People of the Millennium 1 Johann Gutenberg (mass media- movable type) 2 Isaac Newton (gravity) 3 Martin Luther (Protestant Reformation) 4 Charles Darwin (evolutionist writer) 5 William Shakespeare (Renaissance playwright) 6 Christopher Columbus (explorer) 7 Karl Marx (19th c. political writer) 8 Albert Einstein (physicist) 9 Nicolaus Copernicus (astronomy) 10 Galileo Galilei (astronomy)

  3. Movable type • Allows for large populations to be able to absorb knowledge via books, newspapers, etc.

  4. Vendor-specific apps: calendar, calculator, etc. Apps did not work with other systems and did not evolve much over time. No long-tail/custom applications- e.g. family history app Independent apps Developer and user community is engaged Long-tail apps available

  5. Plug does not fit

  6. Issues in Communicating Genetic Information • No simple standard API (Application Programming Interface) • Contents are essentially the same • Sequences (ATGC..) and genetic files • But, data are structured differently • Different approaches of authentication

  7. SMART Provides a Solution • Substitutability Medical Applications Reuseable Technology • Simple design of API • Geared toward developers and users • Integration with clinical data

  8. What is SMART? • Substitutable Medical Apps Reusable Technology • Accelerate medical application innovation and research • Develop medical app community • Remove developer roadblocks

  9. Substitutability = Re-Use Got Statins? BP Centiles CardiacRisk SMART - AMIA 2012 - 04Nov2012 SMART-Enabled PCHR SMART-Enabled HIE SMART-Enabled EMR

  10. Substitutable Apps Needs API Resource oriented, everything a URL Data Model Context (container, user, patient) Medical (problems, allergies, …) Authentication Consistent delegation, web standards (OAuth) UI Standards-based integration (HTML5) SMART - AMIA 2012 - 04Nov2012

  11. App Platform

  12. SMART-Enabling i2b2 Add: SMART cell Mapper cell Patient-Centric View app Patient-Centric View App i2b2 Hive SMART Cell CRC Mapper Cell Ontology Any SMART App SMART - AMIA 2012 - 04Nov2012

  13. Boston Children’s Hospital Cerner EMR 16 Months SMART - AMIA 2012 - 04Nov2012

  14. SMART Genomics API • Enables integration of genomic data from heterogeneous sources • Enables integration of clinical and genomic data • Re-usability eliminates developer barriers • Promotes the use of genetic data for research

  15. SMART Genomics Platform

  16. Pop-Up→ Top-Level Genomics Advisor Displays SMART Genomics Advisor App Integration 24Oct2012

  17. Genomics Advisor: Detailed Pop-Up SMART Genomics Advisor App Integration 24Oct2012

  18. SMART - AMIA 2012 - 04Nov2012

  19. Problem: High cost of chronic disease management and issues with long-term patient compliance in diabetes, especially in pediatric cases. Solution: Increase compliance by integrating toy bear from Sproutel with SMART EMR for physicians and to provide parent/child feedback. Details: Integrated bear with the Telecare glucose meter / pump technology to provide clinical data to SMART EMR* Provides kids with a “fun” way to measure glucose and take insulin. Provide live data for clinicians/patients to view. * Interactive bear avatar gives feedback to patients. * Engages patients to increases their likelihood to comply with their diabetes treatment. Example App: Dbear SMART EMR

  20. iPad Apps

  21. DB EMRFirst program to integrate genomic, device, EMR/Personal Health Record information. First program to integrate patient, patient devices (e.g. bear/glucose meter), care giver, and physician data into a unified view to facilitate collaboration on patient care. First mobile app to integrate genomics/sequence information and clinical information.

  22. Genomics Advisor • Another app using the SMART API • Gives analysis based on genetics

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