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Learning at the Cellular Level

Learning at the Cellular Level. Justin Besant BIONB 2220 Final Project. http://www.unmc.edu/physiology/Mann/mann19.html. Goal. How learning can occur at the cellular level? How this be modeled and simulated quickly using the Izhikevich model? . Learning. Classical Conditioning

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Learning at the Cellular Level

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  1. Learning at the Cellular Level Justin Besant BIONB 2220 Final Project http://www.unmc.edu/physiology/Mann/mann19.html

  2. Goal • How learning can occur at the cellular level? • How this be modeled and simulated quickly using the Izhikevich model?

  3. Learning • Classical Conditioning • US, CS, UR, CR • Hebbian Learning • "When an axon of cell A is near enough to excite a cell B and repeatedly or persistently takes part in firing it, some growth process or metabolic change takes place in one or both cells such that A’s efficiency, as one of the cells firing B, is increased.” – Donald Hebb

  4. Long Term Potentiation • Long term increase in synaptic strength (hours – weeks) • Possible cellular explanation for learning and memory • NMDAR, AMPAR, Calcium Robert C. Malenka, et al. “Long-Term Potentiation: A Decade of Progress?” Science. 285, 1870 (1999).

  5. NMDA Receptors • Incorporate NMDA into the Izhikevich model • Coincidence detector • Voltage dependence of conductance • AMPA receptors and neurotransmitters • Saudargiene, Ausra, et. al.  “Biologically Inspired Artificial Neural Network Algorithm Which Implements Local Learning Rules.” Proceedings of the 2004 International Symposium on Circuits and Systems. 5 (2004) 389-392.

  6. Calcium • 3rdIzhikevich state variable • Spike-timing-dependent-plasticity

  7. AMPA Receptors • Dynamically change concentration

  8. LTP • Two ways to induce LTP • Simultaneous stimulation • Rapid and repetitive stimulation • Example of LTP:

  9. Classical Conditioning

  10. Future Directions and Questions? • Epilepsy • “Learning gone wild?” • Kindling involves glutamate NMDA receptors

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