Contact dermatitis
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Contact dermatitis. William Pinette 30 July, 2010. Toxicodendron diversilobum , Poison-oak. What is it?. Contact Dermatitis:

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Contact dermatitis

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Contact dermatitis

Contactdermatitis

William Pinette

30 July, 2010

Toxicodendron diversilobum, Poison-oak


What is it

What is it?

  • Contact Dermatitis:

    “Contact dermatitis is an eczematous skin reaction caused by direct and usually repeated exposure to harmful objects or chemicals … It is typically characterized by itching papules ... but may vary from slight hyperkeratosis ... and small fissures to extensive redness, swelling and oozing. A histopathological examination of a biopsy shows an acute inflammation in the epidermis.”

    – European Society for Contact Dermatitis

    • Allergic Contact Dermatitis

    • Irritant Contact Dermatitis


Allergic contact dermatitis

Allergic Contact Dermatitis


Allergic contact dermatitis acd

Allergic Contact Dermatitis (ACD)

  • Immune response

    • Delayed Type Hypersensitivity

    • T lymphocytes

  • Allergens

    • Toxicodendron

      • Urushiol

    • Nickel and other metals

    • Latex

    • Chemicals

      • Formaldehyde

      • Perfume


Irritant contact dermatitis icd

Irritant Contact Dermatitis (ICD)

  • No direct immune response

  • Exposure to irritants that compromise the epithelium in various ways

    • Industrial Solvents

    • Oil products

    • Hair products

    • Dimethyl Fumarate

      (DMF)


Prophylaxis

Prophylaxis

  • ACD

    • Cannot “cure” the immune system.

    • Avoid exposure to allergen

    • Wash affected area with soap and cool water

    • Corticosteroids and antihistamine for more severe cases

  • ICD

    • Avoid prolonged exposure to irritants

    • Personal protective equipment

    • Barrier creams


References

References

  • What is contact dermatitis? European Society of Contact Dermatitis. http://www.escd.org/aims/contact_dermatitis

  • Kalish RS, Johnson KL. Enrichment and function of urushiol (poison-ivy)-specific T Lymphocytes in lesions of allergic contact dermatitis to urushiol. J Immunol.(1990) 145: 3706-3713

  • Niyama et. al. Th2 Immune Response Plays a Critical Role in the Development of Nickel-Induced Allergic Contact Dermatitis. Int Arch Allergy Immunol (2010). 153: 303–314

  • Gimenez-Arnaui et al. Shoe contact dermatitis from dimethyl fumarate: clinical manifestations, patch test results, chemical analysis, and source of exposure. Contact Dermatitis (2009) 61: 249–260

  • Chew IL, Maibach HI. Occupational issues of irritant contact dermatitis. Int Arch Occup Environ Health (2003) 76: 339–346


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