Homocysteine and serum lipide levels in pulmonary thromboembolism
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Homocysteine And Serum- Lipide Levels In Pulmonary Thromboembolism. Ayşegül Karalezli, Ebru Şengül Parlak, Ayşegül Şentürk, H. Canan Hasanoğlu Turkısh Thoracıc Socıety 11 . Annual Congress 24.04.2008. Venous thromboembolism is a multifactorial disease.

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Homocysteine And Serum- Lipide Levels In Pulmonary Thromboembolism

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Homocysteine And Serum-Lipide Levels In Pulmonary Thromboembolism

Ayşegül Karalezli, Ebru Şengül Parlak, Ayşegül Şentürk,

H. Canan Hasanoğlu

Turkısh Thoracıc Socıety 11. Annual Congress

24.04.2008


  • Venous thromboembolism is a multifactorialdisease.

  • It has been shown that hyperhomocysteinemia and dyslipidemiaare predisposing factor in deep venous thrombosis and pulmonary thromboembolism in different studies.


Objective

The aim of this study is to investigate the relationship between homocysteine levels and lipid profile in PTE patients


46 PTE patients with average age of 57.9±14.9 and 44 control patients with average age of 49.7±13.8 were enrolled to the study.

21 patient(%45.7) was male and 25 patient (%54.3) was female in the PTE group.

12 patient(%27.3) was male and 32 patient(%72.7) was female in the control group.


In two groups

  • Homocysteine ,

  • Total cholesterol (T.cholesterol),

  • Triglyceride (TG),

  • LDL and HDL cholesterol levels were evaluated.

  • Homocysteine levels and lipid profile (T.cholesterol, TG, LDL, HDL) were compared between two groups.


p<0.05 was accepted as statistically significant value


Homocysteine levels were found high in 33 patients (%71.7) in PTE group (N:5-14 mmol/l)

Homocysteine levels were found high in 15 patients (%34.1) in control group

HDL cholesterol was found low in 18 patients (%39.1) in PTE group

HDL cholesterol was found low in 6 patients (%13.6) in control group


The mean HDL cholesterol level was 35.45 ± 11.26 in 33 PTE patient whose homocysteine levels were high (N:35-60)

The mean HDL cholesterol level was 44.23 ± 13.98 in 14 PTE patients whose homocysteine levels were low.


Hyperhomocysteinemia is a risk factor for vasculer diseases, venous thromboembolism and coranary artery diseases.

MTHFR has a role at methylationof homosistein to methionine .

A decrease at the level of MTHFR levels cause to hyperhomocysteinemia.


Dyslipidemiaand dyslipoproteinemiaare well known risk factors of arterial thrombosis.

There are studies which support effect of high cholesterol levels to the development of PTE.

It has been considered that HDL avoids PTE and low HDL level is a risk factor for PTE.


It is considered that low HDL cholesterol levels can be a risk factor for VTE and the risk can increase when low HDL levels are togather with high homosistein levels.

New studies are needed in this topic.


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