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电解质与药物对 心脏的作用 PowerPoint PPT Presentation


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电解质与药物对 心脏的作用. 人体机能实验中心 卢琼. 目录. 一 . 实验目的 二 . 实验原理及相关知识 三 . 实验材料 四 . 实验步骤 五 . 思考题 六 . 实验小结. 一 . 实验目的. 1. 学习离体蛙心灌流的实验方法 2. 观察内环境 ( interna lenvironment ) 因素的改变和强心甙类药物对离体蛙心活动的影响. 二 . 实验原理及相关知识.

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电解质与药物对 心脏的作用

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  • .

  • .

  • .

  • .

  • .

  • .


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.

  • 1.

  • 2.(interna lenvironment)


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.

  • ,(homeostasis).,.


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,(excitation and contraction).


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1.K+K+


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K+

K+

K+

. Na+


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2.Ca2+,Ca2+.,Ca2+LCa2+,Ca2+,Ca2+,Ca2+100,.(calcium-induced calcium release).


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,Ca2+,;,Ca2+,.


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3.H+H+Ca2+Ca2+

NaHCO3HCO3-H+,H+Ca2+,Ca2+.


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H+

NaHCO3

Ca2+


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4

ERP

eg

Na+K+ATP

K+


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5.(actylcholineAch)

M


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6.(adrenaline,epinephrine).(,positive klinotropic effect)

adr

1


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.

  • BL-420E0.65%NaCl1%KCl2%CaCl232.5%NaHCO31:10000 Actylcholine Ach1:10000Adrenaline AD 0.25g/LKstrophanthin K 10g/L KCl


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.

1

  • (1)

  • (2)


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(3)


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(4)


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2BL-420E

  • (1)

    1.5 ()


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  • (2)

  • (3)BL-Newcentury

  • (4)


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3

(1)


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(2)0.65%NaCl,


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(3)3 CaCl212

(4)1KCl1

(5)110,00012


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(6)110,00012

(7) 3%1122.5%NaHCO3,


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(8)300.25g/LK0.2ml

(9)10g/L KCl24


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  • 1

  • 2


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  • 312


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  • 4

  • 5

  • 6


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.


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.

  • ,

2 K


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3K+Ca2+H+ADAch


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THE END

thanks


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