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TF. TF. fVIIa. TF. TF. TF. TF. TF. TF. fVIIa: 1% of total FVII. fVIIa. TF. TF. TF. TF. TF. TF. TF. TF. aPlt. Va. ATIII. Va. VIIIa. XIa. IXa. Xa. IIa. VIIa. fVIIa. fVIIa. Ca. Ca. TFPI. Xa. Va. Xa. TF. TF. Plt. V. VIII. XI. X. IX. II. fVIIa. TF. VII.
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TF TF fVIIa TF TF TF TF TF TF fVIIa: 1% of total FVII fVIIa TF TF TF TF TF TF
TF TF aPlt Va ATIII Va VIIIa XIa IXa Xa IIa VIIa fVIIa fVIIa Ca Ca TFPI Xa Va Xa TF TF Plt V VIII XI X IX II fVIIa TF VII TF Anionic membrane TF TF prothrombinase Initiation TF TF TF TF Ext tenase
aPlt Va VIIIa XIa VIIIa IXa IIa VIIa XIIIa IXa APC Ca VIIIa Va Ca Xa Va IIa IXa Active Platelet TM XIa Plt V VIII Main path of XI XI XIII VII II X IX prothrombinase propagation Int tenase
See You • Clinical significant??? • Factor • F XII deficiency • Prekallikrein deficiency • High-molecular-weight kinogen deficiency • Mild to moderate factor VII deficiency • lpus anticoagulants • Excess citrate anticoagulant (e with HCT>60%) Symptom(+) Lab (+) and Sym(-) Screen Lab: APTT, PT and PLt (-) • vWD • Plt function • In release; Scott syndrome • Factor • FXIII • Heterozygous carriere of inherited coagulation diorder: • FIX deficiency • Mild inherited coagulation disorder: • FXI deficiency • Dysfibrinogenemia • Fibrinolysis • Plasmin inhibitor deficiency • Elegated of plasminogen activator • Hereditary hemorrhagic telangiectasis • Allergic and other vascular purpura (+) • Confirmatory test • mixted aPTT; mixed PT 0 and 2 hour • If corrected (N+P < buffer+normal) • Factor deficiency • Or weak antibody • If not antibody • 1. Anti phospholipid Ab ( no clincal importance) on 0 hr • 2. Factor antibody ex: VIII ab ( delay titier: 2 hr more long)
