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Incu Vive : A Modular Incubation System for the Developing World

Incu Vive : A Modular Incubation System for the Developing World. Indrias Bekerie , Annabelle Chu Yan Fui , Leeanna Hyacinth, Min Ye Shen , and Kiet Vo Department of Biomedical Engineering, Columbia University. BME Senior Design 2011-2012 May 1 st , 2012.

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Incu Vive : A Modular Incubation System for the Developing World

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  1. IncuVive: A Modular Incubation System for the Developing World IndriasBekerie, Annabelle Chu Yan Fui, Leeanna Hyacinth, Min Ye Shen, and KietVo Department of Biomedical Engineering, Columbia University BME Senior Design 2011-2012 May 1st, 2012

  2. Motivation: Combat Infant Hypothermia • 99% of neonatal deaths occur in developing countries • Hypothermia contributes up to 42% of the 4 million annual infant deathsin the developing world • Millennium Development Goal #4: Reduce child mortality • Reduce under-five mortality rate by 2/3 • 38% of all under-five deaths occurs in the neonatal period [Millennium Project, 2006] [World Health Organization, 2001] [UNICEF, 2007]

  3. Need: Cheap and Effective Solution to Warm Infant • Low-resource areas lack personnel and resources (e.g. Mulago Hospital in Kampala, Uganda) • 60% of babies born premature • 2 nurses for 60 babies • 2 incubators (out of 20) are working There is a need for an infant-warming system that can both work on its own and repurpose nonfunctioning incubators.

  4. Current Solutions Used in the NICU Incubator Kangaroo care Heat pad [World Health Organization, 2001]

  5. Functional Requirements and Constraints Functional Requirements • Increase infant temperature to normal range of 36.5-37.5 °C • Maintain infant temperature for at least 24 hours Constraints • Low cost • Low power • Easy to maintain and repair • High controllability • Easy to use • Safe

  6. Our Solution: Warm Water Circulation Mat Our Solution: Warm Water Circulation Mat Practical Specifications • Designed specifically for low-resource settings • Components can be found locally • Can function as a stand-alone incubator • Can repurpose non-functioning incubators Product Features • Warm water circulation system to prevent overheating or burning • Requires no humidification • Controlled by a feedback algorithm with fail-safes • Different design configurations • Can have 1+ mat per system

  7. Final Prototype Current prototype Inlet Control Panel Mat Outlet Heater Pump Reservoir • Made from readily available materials • Can be switched for cheaper components found locally

  8. Feedback Algorithm and Fail-Safes Feedback algorithm and fail-safes Thermistors Arduino Manual switch Relay Heater Feedback Thermistor Comparator

  9. Able to raise and maintain the temperature of the biofluid from hypothermic to normal temperature range. Effectiveness of Our System

  10. Effectiveness of Our System +/- std err Able to raise and maintain the temperature of the biofluid from hypothermic to within normal temperature range.

  11. Effectiveness of Our System Incubator • Average of 85 min to raise temperature by 1 C Our device • With fold over average of 50 min per 1 C • Without fold-over average of 90 min per 1 C +/- std err [Testing on Inubator done at CUMC, 4/26/2012, on Giraffe OHMEDA Medical Incubator]

  12. Economic Feasibility Final Prototype cost : $98.01 Commercial cost of system: $50 • Low power consumption • 2.3 kWh/day • Equivalent using a 100 W light bulb for 24 hours • Low water requirement • 1 L to fill mat • $0.01 for 10L • Repair Cost: • $0.03-$11 • Water heater- most expensive component

  13. Future Work Future Work • Optimize design and minimize cost and power consumption • Heating unit versatility • Multiple mats/unit • Backup power • Instruction manual Our modular incubation system is able to work on its own or repurpose non-functional incubators to combat infant hypothermia in the developing world.

  14. Acknowledgements Instructors • Aaron Kyle, Ph.D. , Biomedical Engineering Dept., Columbia University • Elizabeth Hillman, Ph.D. , Biomedical Engineering Dept., Columbia University • Keith Yeager • Sarah De Leo (TA) • David Jangraw (TA) Advisers and Consultants • Lance Kam, Ph.D., Biomedical Engineering Dept., Columbia University • Margaret Nakakeeto-Kijjambu, MD, Mulago Hospital • Richard Polin, MD, CUMC Pediatrics • RakeshSahni, MD, CUMC Pediatrics • Helen Towers, MD, CUMC Pediatrics • Yvonne Vaucher, MD, UCSD • David Vallancourt, Ph.D., Electrical Engineering Dept., Columbia University

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