Cardiorenal syndrome monash university australia 2008 2012
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รายงานการลาศึกษาต่อระดับปริญญาเอก เรื่อง cardiorenal syndrome PowerPoint PPT Presentation


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รายงานการลาศึกษาต่อระดับปริญญาเอก เรื่อง cardiorenal syndrome ณ Monash University, Australia (2008-2012). ผศ. พญ. สุรีย์ เลขวรรณ วิจิตร 15 May 2012. Cardiorenal syndrome.

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Cardiorenal syndrome monash university australia 2008 2012

รายงานการลาศึกษาต่อระดับปริญญาเอก

เรื่อง cardiorenal syndrome

ณ Monash University, Australia (2008-2012)

ผศ.พญ.สุรีย์ เลขวรรณวิจิตร

15 May 2012


Cardiorenal syndrome

Cardiorenal syndrome

Hypothesis1: Indoxyl sulfate has adverse cardiac effects.Hypothesis2: MI causes renal function and structural changes over time.

Increased CV morbidity & mortality

Pathologic remodeling

Diminished blood flow

Neurohormonal activation

Vasoconstriction

hemodynamics

Oxidative stress

Diuretic therapy

Inflammation

Neurohormonal activation

Anemia

non-dialyzable uraemic toxins?

Indoxyl sulfate (IS)


Cardiac fibroblast

Cardiac fibroblast

Indoxyl sulfate: In vitro study

Cardiac myocyte

Collagen synthesis

Protein synthesis

THP-1 cell: Pro-inflammatory cytokine gene expression


Cardiorenal syndrome

Indoxyl sulfate: In vivo study

AST-120

GI tract

Indoxyl sulfate

(circulation)

OAT1 and 3

urine


Cardiorenal syndrome

Cardiac Fibrosis

Sham STNx+Vehicle STNx+AST-120

0.8X

0.8X

0.8X


Cardiorenal syndrome

Renal changes post-MI: In vivo study


Cardiorenal syndrome

In vivo MI–AST120 study

Background

MI (16 weeks) renal fibrosis


Results

Serum IS

Results

Heart Kidney


Publications

Publications

  • Lekawanvijit S, Adrahtas A, Kelly DJ, Kompa AR, Krum H, Wang B. Does Indoxyl Sulfate, A Uraemic Toxin, Have Direct Effects on Cardiac Fibroblasts & Myocytes? Eur Heart J 2010;31(14):1771-1779.

  • Krum H, Iyngkaran P, Lekawanvijit S. Pharmacological Management of the Cardiorenal Syndrome in Heart Failure. Current Heart Failure Reports 2009;6:105-111.

  • Lekawanvijit S, Kompa AR, Zhang Y, Wang BH, Kelly DJ, Krum H. Myocardial Infarction Impairs Renal Function, Induces Renal Interstitial Fibrosis and Increases renal KIM-1 Expression: Implications for Cardiorenal Syndrome. Am J Physiol Heart Circ Physiol. 2012 Feb 24. [Epub ahead of print]

  • Liu S, Lekawanvijit S, Kompa AR, Wang BH, Kelly DJ, Krum H. Cardiorenal Syndrome: Pathophysiology, Preclinical Models, Management and Potential Role of Uraemic Toxins. Clin Exp Pharmacol Physiol. 2011 Oct 20. doi: 10.1111/j.1440-1681.2011.05632.x. [Epub ahead of print]

  • Lekawanvijit S, Kompa A, Manabe M, Kelly DJ, Krum H. Chronic Kidney Disease-Induced Cardiac Fibrosis is Ameliorated by Reducing Circulating Levels of a Non-Dialysable Uraemic Toxin, Indoxyl Sulfate. (Under review at PLOS One)

Presentation title


Conference communications

Conference communications

  • Lekawanvijit S, Kompa A, Wang BH, Nishijima F, Kelly DJ, Krum H. Chronic Kidney Disease-Induced Cardiac Fibrosis is Ameliorated by Reducing Circulating Levels of a Non-Dialysable Uraemic Toxin, Indoxyl Sulfate Reducing Circulating Levels of Indoxyl Sulfate, a Non-Dialysable Uremic Toxin, Ameliorates Chronic Kidney Disease-Induced Cardiac Fibrosis. In: The Japanese Circulation Society 16-18 March 2012. Fukuoka, Japan.

  • Lekawanvijit S, Kompa AR, Manabe M, Kelly DJ, Krum H. Reduction of renal fibrosis as well as cardiac pro-fibrotic and pro-inflammatory mRNA expression by an oral charcoal adsorbent, AST-120, in post-MI rats. In: The American Heart Association Scientific Sessions 12-16 November 2011. Orlando, Florida, USA.

  • Lekawanvijit S, Kompa A, Wang BH, Nishijima F, Kelly DJ, Krum H. Chronic Kidney Disease-Induced Cardiac Fibrosis is Ameliorated by Reducing Circulating Levels of a Non-Dialysable Uraemic Toxin, Indoxyl Sulfate. In: The ASN Kidney Week, 8-13 November 2011, Philadelphia, Pennsylvania, USA.

  • Lekawanvijit S, Kompa AR, Manabe M, Kelly DJ, Krum H. Reducing circulating levels of a non-dialysable uraemic toxin, indoxyl sulfate, ameliorates chronic kidney disease-induced cardiac fibrosis. In: The European Society of Cardiology Congress 2011. Paris, France; European Heart Journal 2011, 32 (Abstract Supplement):1002.

  • Lekawanvijit S, Kompa AR, Manabe M, Wang BH, Kelly DJ, Krum H. Chronic Kidney Disease-Induced Cardiac Fibrosis is Ameliorated by Reducing Circulating Levels of a Non-Dialysable Uraemic Toxin, Indoxyl Sulfate. In: The CSANZ 59th Annual Scientific Meeting. Perth, Australia; Heart, Lung and Circulation 2011, 20;S61.

  • Lekawanvijit S, Kompa A, Manabe M, Kelly DJ, Krum H. An oral charcoal adsorbent, AST-120, reduces renal fibrosis as well as cardiac pro-fibrotic and pro-inflammatory mRNA expression post-MI in the rat. In: The CSANZ 59th Annual Scientific Meeting. Perth, Australia; Heart, Lung and Circulation 2011, 20;S58.

  • Lekawanvijit S, Kompa A, Manabe M, Kelly DJ, Krum H. Chronic Kidney Disease-Induced Cardiac Fibrosis is Ameliorated by Reducing Circulating Levels of a Non-Dialysable Uraemic Toxin, Indoxyl Sulfate. In: The American College of Cardiology 60th Annual Scientific Session and i2 Summit, April 2-5, 2011, New Orleans, Louisiana, USA; J Am Coll Cardiol 2011; 57:192.


Conference communications cont

Conference communications (cont.)

  • Lekawanvijit S, Kompa A, Manabe M, Kelly DJ, Krum H. Chronic Kidney Disease-Induced Cardiac Fibrosis is Ameliorated by Reducing Circulating Levels of a Non-Dialysable Uraemic Toxin, Indoxyl Sulfate. In: The 44ht Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Annual Scientific Meeting. Melbourne, Australia. 28 November – 1 December, 2010.

  • Lekawanvijit S, Kompa A, Zhang Y, Wang BH, Kelly DJ, Krum H. Myocardial infarction impairs renal function, induces renal interstitial fibrosis and increases Kim-1 expression: Implications for the cardiorenal syndrome. In: The CSANZ 58th Annual Scientific Meeting. Adelaide, Australia; Heart, Lung and Circulation 2010, 19;S76-77.

  • Lekawanvijit S, Kompa A, Zhang Y, Wang BH, Kelly DJ, Krum H. Myocardial infarction impairs renal function, induces renal interstitial fibrosis and increases Kim-1 expression: Implications for the cardiorenal syndrome. In: The American Heart Association Scientific Sessions 2009. Orlando, Florida, USA; Circulation 2009, 120:S1076.

  • Lekawanvijit S, Adrahtas A, Kelly DJ, Kompa AR, Krum H, Wang B. Does Indoxyl Sulfate, A Uraemic Toxin, Have Direct Effects on Cardiac Fibroblasts & Myocytes? In: The CSANZ 57th Annual Scientific Meeting. Sydney, Australia; Heart, Lung and Circulation 2009, 18(suppl 3);S174.

  • Lekawanvijit S, Adrahtas A, Kelly DJ, Kompa AR, Krum H, Wang B. Does Indoxyl Sulfate, A Uraemic Toxin, Have Direct Effects on Cardiac Fibroblasts & Myocytes? In: The American Heart Association Scientific Sessions 2008. New Orleans, Louisiana, USA; Circulation 2008, 118(suppl 2):S338.

  • Lekawanvijit S, Adrahtas A, Kelly DJ, Kompa AR, Krum H, Wang B. Does Indoxyl Sulfate, A Uraemic Toxin, Have Direct Effects on Cardiac Fibroblasts & Myocytes? In: The Alfred Week Research Poster Display. 20-24 October, 2008.


Acknowledgements

Acknowledgements

Supervisors

  • Professor Henry Krum

  • Professor Darren Kelly

  • Dr. Andrew Kompa

  • Dr. Bing Wang

  • Monash University

  • University of Melbourne

  • Prince Doctor Fund

  • Faculty of Medicine

  • Chiang Mai University

  • Thailand


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