Risk factors
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RISK FACTORS. Age 60s or older Increases with age 3x higher in women Family History Familial autosomal dominant Earlier onset risk increases if more than one family member has the illness Genetics Late-onset Apolipoprotein E ( ApoE )

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RISK FACTORS

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Risk factors

RISK FACTORS

  • Age

    • 60s or older

    • Increases with age

    • 3x higher in women

  • Family History

    • Familial autosomal dominant

    • Earlier onset

    • risk increases if more than one family member has the illness

  • Genetics

    • Late-onset

    • Apolipoprotein E (ApoE)

      • ApoE4 increases the risk of developing the disease


Potential contributing factors

Potential Contributing Factors

  • Cardiovascular disease

    • High blood pressure may damage blood vessels in the brain, disrupting regions that are important in decision-making, memory and verbal skills

    • High cholesterol may inhibit the ability of the blood to clear protein from the brain.

  • Type 2 Diabetes:

    • insulin does not work effectively to convert blood sugar into energy  production of higher levels of insulin and blood sugar which may harm the brain and contribute to the progression of Alzheimer's

  • Oxidative Damage

    • Free radicals are unstable molecules which can harm cells and tissue and may contribute to the neuronal brain cell damage caused by Alzheimer's.

  • Inflammation

    • As protein plaques develop, inflammation results, but it is not known whether this process is damaging and a cause of Alzheimer's, or part of an immune response attempting to contain the disease.

  • Other Possible Risk Factors

    • prior traumatic head injury, lower education level and female gender as possible risk factors.

    • Alzheimer's disease may also be associated with an immune system reaction or a virus.


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